Damian Toczydlowski
@damiantoczydlowski.bsky.social
Epigeneticist, Scientist & Molecular Biologist studying epigenetic cellular memory, epigenetic inheritance & mechano-epigenomic code in gliomas.
#epigenomics #epigenetics #singlecell #chromatin
https://www.linkedin.com/in/damian-toczydlowski/
#epigenomics #epigenetics #singlecell #chromatin
https://www.linkedin.com/in/damian-toczydlowski/
If James Watson and Francis Crick hadn't seen Rosalind Franklin and Raymond Gosling's 𝘗𝘩𝘰𝘵𝘰𝘨𝘳𝘢𝘱𝘩 51 (which Maurice Wilkins showed them), would they still have come up with the idea of the double helix in 1953?
November 23, 2025 at 1:30 PM
If James Watson and Francis Crick hadn't seen Rosalind Franklin and Raymond Gosling's 𝘗𝘩𝘰𝘵𝘰𝘨𝘳𝘢𝘱𝘩 51 (which Maurice Wilkins showed them), would they still have come up with the idea of the double helix in 1953?
Reposted by Damian Toczydlowski
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
𝐆𝐫𝐞𝐠𝐨𝐫 𝐌𝐞𝐧𝐝𝐞𝐥'𝐬 𝐩𝐞𝐚 𝐩𝐥𝐚𝐧𝐭 𝐞𝐱𝐩𝐞𝐫𝐢𝐦𝐞𝐧𝐭𝐬, 𝐨𝐯𝐞𝐫𝐥𝐨𝐨𝐤𝐞𝐝 𝐟𝐨𝐫 𝐝𝐞𝐜𝐚𝐝𝐞𝐬, 𝐬𝐨𝐰𝐞𝐝 𝐭𝐡𝐞 𝐠𝐫𝐨𝐮𝐧𝐝𝐰𝐨𝐫𝐤 𝐟𝐨𝐫 (𝐄𝐩𝐢)𝐠𝐞𝐧𝐞𝐭𝐢𝐜𝐬
Do you recall the story of Gregor Mendel, the monk?
Yes, that man, who with relentless passion, crossbred his pea plants in the quiet gardens of the Augustinian monastery.
#science #genetics
Do you recall the story of Gregor Mendel, the monk?
Yes, that man, who with relentless passion, crossbred his pea plants in the quiet gardens of the Augustinian monastery.
#science #genetics
September 20, 2025 at 10:17 AM
𝐄𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐦𝐞𝐦𝐨𝐫𝐲 𝐢𝐧 𝐚 𝐧𝐞𝐰 𝐥𝐢𝐠𝐡𝐭
It might sound like science fiction...
But your cells actually have a form of memory.
Not the kind you use to remember your grocery list, but something far more sophisticated.
#epigenetics #science #genomics
It might sound like science fiction...
But your cells actually have a form of memory.
Not the kind you use to remember your grocery list, but something far more sophisticated.
#epigenetics #science #genomics
September 17, 2025 at 3:52 PM
𝐄𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐦𝐞𝐦𝐨𝐫𝐲 𝐢𝐧 𝐚 𝐧𝐞𝐰 𝐥𝐢𝐠𝐡𝐭
It might sound like science fiction...
But your cells actually have a form of memory.
Not the kind you use to remember your grocery list, but something far more sophisticated.
#epigenetics #science #genomics
It might sound like science fiction...
But your cells actually have a form of memory.
Not the kind you use to remember your grocery list, but something far more sophisticated.
#epigenetics #science #genomics
𝐄𝐝𝐢𝐭𝐢𝐧𝐠 𝐭𝐡𝐞 𝐄𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐞 𝐚𝐜𝐫𝐨𝐬𝐬 𝐥𝐞𝐧𝐠𝐭𝐡 𝐬𝐜𝐚𝐥𝐞𝐬
At some point, once scientists started exploring cellular epigenomes in more detail, they hit a glass ceiling.
What slowed down the progress?
#epigenetics #genomics #crispr
At some point, once scientists started exploring cellular epigenomes in more detail, they hit a glass ceiling.
What slowed down the progress?
#epigenetics #genomics #crispr
March 22, 2025 at 11:30 AM
𝐄𝐝𝐢𝐭𝐢𝐧𝐠 𝐭𝐡𝐞 𝐄𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐞 𝐚𝐜𝐫𝐨𝐬𝐬 𝐥𝐞𝐧𝐠𝐭𝐡 𝐬𝐜𝐚𝐥𝐞𝐬
At some point, once scientists started exploring cellular epigenomes in more detail, they hit a glass ceiling.
What slowed down the progress?
#epigenetics #genomics #crispr
At some point, once scientists started exploring cellular epigenomes in more detail, they hit a glass ceiling.
What slowed down the progress?
#epigenetics #genomics #crispr
𝐇𝐨𝐰 𝐝𝐨𝐞𝐬 𝐭𝐡𝐞 𝐆𝐞𝐧𝐨𝐦𝐞 𝐬𝐞𝐥𝐟-𝐨𝐫𝐠𝐚𝐧𝐢𝐬𝐞?
One of the biggest surprises for geneticists came when they started breaking down the sequence of human DNA into its constituent parts.
Do you know how it went at the beginning?
#epigenetics #genomics #science
One of the biggest surprises for geneticists came when they started breaking down the sequence of human DNA into its constituent parts.
Do you know how it went at the beginning?
#epigenetics #genomics #science
March 16, 2025 at 10:22 AM
𝐇𝐨𝐰 𝐝𝐨𝐞𝐬 𝐭𝐡𝐞 𝐆𝐞𝐧𝐨𝐦𝐞 𝐬𝐞𝐥𝐟-𝐨𝐫𝐠𝐚𝐧𝐢𝐬𝐞?
One of the biggest surprises for geneticists came when they started breaking down the sequence of human DNA into its constituent parts.
Do you know how it went at the beginning?
#epigenetics #genomics #science
One of the biggest surprises for geneticists came when they started breaking down the sequence of human DNA into its constituent parts.
Do you know how it went at the beginning?
#epigenetics #genomics #science
𝐍𝐞𝐰 𝐬𝐭𝐞𝐦 𝐜𝐞𝐥𝐥𝐬 𝐰𝐢𝐭𝐡 𝐡𝐢𝐠𝐡 𝐩𝐥𝐚𝐬𝐭𝐢𝐜𝐢𝐭𝐲, 𝐥𝐨𝐰 𝐢𝐦𝐦𝐮𝐧𝐨𝐠𝐞𝐧𝐢𝐜𝐢𝐭𝐲, & 𝐧𝐨 𝐭𝐮𝐦𝐨𝐮𝐫 𝐫𝐢𝐬𝐤, 𝐭𝐡𝐚𝐭 𝐡𝐞𝐚𝐥 𝐬𝐤𝐢𝐧 𝐰𝐨𝐮𝐧𝐝𝐬 — 𝐂𝐚𝐧 𝐫𝐞𝐠𝐞𝐧𝐞𝐫𝐚𝐭𝐢𝐯𝐞 𝐦𝐞𝐝𝐢𝐜𝐢𝐧𝐞 𝐚𝐬𝐤 𝐟𝐨𝐫 𝐦𝐨𝐫𝐞?
I will only say that we haven't had a breakthrough like this in a long time.
#regenerativemedicine #stemcells #science
I will only say that we haven't had a breakthrough like this in a long time.
#regenerativemedicine #stemcells #science
March 12, 2025 at 12:41 PM
𝐍𝐞𝐰 𝐬𝐭𝐞𝐦 𝐜𝐞𝐥𝐥𝐬 𝐰𝐢𝐭𝐡 𝐡𝐢𝐠𝐡 𝐩𝐥𝐚𝐬𝐭𝐢𝐜𝐢𝐭𝐲, 𝐥𝐨𝐰 𝐢𝐦𝐦𝐮𝐧𝐨𝐠𝐞𝐧𝐢𝐜𝐢𝐭𝐲, & 𝐧𝐨 𝐭𝐮𝐦𝐨𝐮𝐫 𝐫𝐢𝐬𝐤, 𝐭𝐡𝐚𝐭 𝐡𝐞𝐚𝐥 𝐬𝐤𝐢𝐧 𝐰𝐨𝐮𝐧𝐝𝐬 — 𝐂𝐚𝐧 𝐫𝐞𝐠𝐞𝐧𝐞𝐫𝐚𝐭𝐢𝐯𝐞 𝐦𝐞𝐝𝐢𝐜𝐢𝐧𝐞 𝐚𝐬𝐤 𝐟𝐨𝐫 𝐦𝐨𝐫𝐞?
I will only say that we haven't had a breakthrough like this in a long time.
#regenerativemedicine #stemcells #science
I will only say that we haven't had a breakthrough like this in a long time.
#regenerativemedicine #stemcells #science
𝐀𝐫𝐜𝐡𝐢𝐭𝐞𝐜𝐭𝐮𝐫𝐚𝐥 𝐟𝐞𝐚𝐭𝐮𝐫𝐞𝐬 𝐨𝐟 𝐭𝐡𝐞 𝐞𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐞
Our DNA – probably one of the most valuable resources that we possess – is packed in our cells in a fantastic, clever way.
#epigenetics #genomics #chromatin
Our DNA – probably one of the most valuable resources that we possess – is packed in our cells in a fantastic, clever way.
#epigenetics #genomics #chromatin
March 11, 2025 at 2:50 PM
𝐀𝐫𝐜𝐡𝐢𝐭𝐞𝐜𝐭𝐮𝐫𝐚𝐥 𝐟𝐞𝐚𝐭𝐮𝐫𝐞𝐬 𝐨𝐟 𝐭𝐡𝐞 𝐞𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐞
Our DNA – probably one of the most valuable resources that we possess – is packed in our cells in a fantastic, clever way.
#epigenetics #genomics #chromatin
Our DNA – probably one of the most valuable resources that we possess – is packed in our cells in a fantastic, clever way.
#epigenetics #genomics #chromatin
𝐈𝐧𝐭𝐞𝐠𝐫𝐚𝐭𝐢𝐧𝐠 𝐑𝐍𝐀 & 𝐃𝐍𝐀 𝐢𝐦𝐚𝐠𝐢𝐧𝐠 𝐰𝐢𝐭𝐡 𝐌𝐄𝐑𝐅𝐈𝐒𝐇 𝐞𝐱𝐩𝐨𝐬𝐞𝐝 𝐜𝐞𝐥𝐥 𝐭𝐲𝐩𝐞–𝐬𝐩𝐞𝐜𝐢𝐟𝐢𝐜 𝟑𝐃 𝐠𝐞𝐧𝐨𝐦𝐞 𝐨𝐫𝐠𝐚𝐧𝐢𝐬𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐭𝐡𝐞 𝐦𝐨𝐮𝐬𝐞 𝐜𝐞𝐫𝐞𝐛𝐫𝐚𝐥 𝐜𝐨𝐫𝐭𝐞𝐱
Until a certain point in the history of molecular biology, methods for DNA & RNA sequencing were developed separately.
#epigenetics #epigenomics #genomics
Until a certain point in the history of molecular biology, methods for DNA & RNA sequencing were developed separately.
#epigenetics #epigenomics #genomics
March 9, 2025 at 4:13 PM
𝐈𝐧𝐭𝐞𝐠𝐫𝐚𝐭𝐢𝐧𝐠 𝐑𝐍𝐀 & 𝐃𝐍𝐀 𝐢𝐦𝐚𝐠𝐢𝐧𝐠 𝐰𝐢𝐭𝐡 𝐌𝐄𝐑𝐅𝐈𝐒𝐇 𝐞𝐱𝐩𝐨𝐬𝐞𝐝 𝐜𝐞𝐥𝐥 𝐭𝐲𝐩𝐞–𝐬𝐩𝐞𝐜𝐢𝐟𝐢𝐜 𝟑𝐃 𝐠𝐞𝐧𝐨𝐦𝐞 𝐨𝐫𝐠𝐚𝐧𝐢𝐬𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐭𝐡𝐞 𝐦𝐨𝐮𝐬𝐞 𝐜𝐞𝐫𝐞𝐛𝐫𝐚𝐥 𝐜𝐨𝐫𝐭𝐞𝐱
Until a certain point in the history of molecular biology, methods for DNA & RNA sequencing were developed separately.
#epigenetics #epigenomics #genomics
Until a certain point in the history of molecular biology, methods for DNA & RNA sequencing were developed separately.
#epigenetics #epigenomics #genomics
𝐆𝐞𝐧𝐞 𝐓𝐡𝐞𝐫𝐚𝐩𝐲: 𝐓𝐡𝐞𝐧, 𝐍𝐨𝐰, & 𝐁𝐞𝐲𝐨𝐧𝐝...
Gene therapies wouldn't exist if we couldn't sequence the human genome.
They wouldn't exist without the breakthroughs in genome editing or the methods to deliver what some call "fixed genes" into patients' bodies.
#genetherapy
Gene therapies wouldn't exist if we couldn't sequence the human genome.
They wouldn't exist without the breakthroughs in genome editing or the methods to deliver what some call "fixed genes" into patients' bodies.
#genetherapy
March 5, 2025 at 4:54 PM
𝐆𝐞𝐧𝐞 𝐓𝐡𝐞𝐫𝐚𝐩𝐲: 𝐓𝐡𝐞𝐧, 𝐍𝐨𝐰, & 𝐁𝐞𝐲𝐨𝐧𝐝...
Gene therapies wouldn't exist if we couldn't sequence the human genome.
They wouldn't exist without the breakthroughs in genome editing or the methods to deliver what some call "fixed genes" into patients' bodies.
#genetherapy
Gene therapies wouldn't exist if we couldn't sequence the human genome.
They wouldn't exist without the breakthroughs in genome editing or the methods to deliver what some call "fixed genes" into patients' bodies.
#genetherapy
𝐇𝐨𝐰 𝐜𝐚𝐧 𝐭𝐡𝐞 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐨𝐫𝐲 𝐫𝐮𝐥𝐞𝐬 𝐨𝐟 𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐞𝐥𝐞𝐦𝐞𝐧𝐭𝐬 𝐛𝐞 𝐝𝐞𝐜𝐢𝐩𝐡𝐞𝐫𝐞𝐝?
"Sire, Your Grace, genome, tell us who we truly are," they said.
At one time, scientists thought that sequencing the human genome would mark the end of a certain era in history.
#genomics #epigenetics
"Sire, Your Grace, genome, tell us who we truly are," they said.
At one time, scientists thought that sequencing the human genome would mark the end of a certain era in history.
#genomics #epigenetics
March 2, 2025 at 3:59 PM
𝐇𝐨𝐰 𝐜𝐚𝐧 𝐭𝐡𝐞 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐨𝐫𝐲 𝐫𝐮𝐥𝐞𝐬 𝐨𝐟 𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐞𝐥𝐞𝐦𝐞𝐧𝐭𝐬 𝐛𝐞 𝐝𝐞𝐜𝐢𝐩𝐡𝐞𝐫𝐞𝐝?
"Sire, Your Grace, genome, tell us who we truly are," they said.
At one time, scientists thought that sequencing the human genome would mark the end of a certain era in history.
#genomics #epigenetics
"Sire, Your Grace, genome, tell us who we truly are," they said.
At one time, scientists thought that sequencing the human genome would mark the end of a certain era in history.
#genomics #epigenetics
𝐓𝐡𝐞𝐫𝐞 𝐰𝐨𝐮𝐥𝐝 𝐛𝐞 𝐧𝐨 𝐥𝐢𝐟𝐞, 𝐧𝐨 𝐜𝐞𝐥𝐥𝐮𝐥𝐚𝐫 𝐬𝐲𝐬𝐭𝐞𝐦𝐬 — 𝐰𝐞 𝐰𝐨𝐮𝐥𝐝 𝐧𝐞𝐯𝐞𝐫 𝐭𝐚𝐤𝐞 𝐨𝐮𝐫 𝐟𝐢𝐫𝐬𝐭 𝐛𝐫𝐞𝐚𝐭𝐡 𝐰𝐢𝐭𝐡𝐨𝐮𝐭 𝐭𝐫𝐚𝐧𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧...
Transcription?
For some, it is just a meaningless word.
To others?
A molecular process.
#transcriptomics #epigenetics #genomics
Transcription?
For some, it is just a meaningless word.
To others?
A molecular process.
#transcriptomics #epigenetics #genomics
February 27, 2025 at 9:51 AM
𝐓𝐡𝐞𝐫𝐞 𝐰𝐨𝐮𝐥𝐝 𝐛𝐞 𝐧𝐨 𝐥𝐢𝐟𝐞, 𝐧𝐨 𝐜𝐞𝐥𝐥𝐮𝐥𝐚𝐫 𝐬𝐲𝐬𝐭𝐞𝐦𝐬 — 𝐰𝐞 𝐰𝐨𝐮𝐥𝐝 𝐧𝐞𝐯𝐞𝐫 𝐭𝐚𝐤𝐞 𝐨𝐮𝐫 𝐟𝐢𝐫𝐬𝐭 𝐛𝐫𝐞𝐚𝐭𝐡 𝐰𝐢𝐭𝐡𝐨𝐮𝐭 𝐭𝐫𝐚𝐧𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧...
Transcription?
For some, it is just a meaningless word.
To others?
A molecular process.
#transcriptomics #epigenetics #genomics
Transcription?
For some, it is just a meaningless word.
To others?
A molecular process.
#transcriptomics #epigenetics #genomics
𝐓𝐡𝐞 𝐟𝐫𝐚𝐠𝐢𝐥𝐢𝐭𝐲 𝐨𝐟 𝐜𝐞𝐥𝐥𝐮𝐥𝐚𝐫 (𝐞𝐩𝐢)𝐠𝐞𝐧𝐨𝐦𝐞𝐬: 𝐍𝐨𝐭 𝐨𝐧𝐥𝐲 𝐃𝐍𝐀, 𝐛𝐮𝐭 𝐚𝐥𝐬𝐨 𝐑𝐍𝐀 𝐜𝐚𝐧 𝐛𝐞 𝐝𝐚𝐦𝐚𝐠𝐞𝐝
Nucleic acids are neither "immortal" nor made of iron.
They can't be endlessly damaged.
#genomics #epigenetics
Nucleic acids are neither "immortal" nor made of iron.
They can't be endlessly damaged.
#genomics #epigenetics
February 24, 2025 at 5:06 PM
𝐓𝐡𝐞 𝐟𝐫𝐚𝐠𝐢𝐥𝐢𝐭𝐲 𝐨𝐟 𝐜𝐞𝐥𝐥𝐮𝐥𝐚𝐫 (𝐞𝐩𝐢)𝐠𝐞𝐧𝐨𝐦𝐞𝐬: 𝐍𝐨𝐭 𝐨𝐧𝐥𝐲 𝐃𝐍𝐀, 𝐛𝐮𝐭 𝐚𝐥𝐬𝐨 𝐑𝐍𝐀 𝐜𝐚𝐧 𝐛𝐞 𝐝𝐚𝐦𝐚𝐠𝐞𝐝
Nucleic acids are neither "immortal" nor made of iron.
They can't be endlessly damaged.
#genomics #epigenetics
Nucleic acids are neither "immortal" nor made of iron.
They can't be endlessly damaged.
#genomics #epigenetics
Reposted by Damian Toczydlowski
𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇
Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability
Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.
tinyurl.com
February 19, 2025 at 7:35 PM
𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇
𝐂𝐑𝐈𝐒𝐏𝐑-𝐛𝐚𝐬𝐞𝐝 𝐞𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐞 𝐞𝐝𝐢𝐭𝐢𝐧𝐠 𝐮𝐧𝐜𝐨𝐯𝐞𝐫𝐬 𝐭𝐡𝐞 𝐦𝐢𝐬𝐬𝐢𝐧𝐠 𝐥𝐢𝐧𝐤𝐬 𝐢𝐧 𝐠𝐞𝐧𝐨𝐦𝐢𝐜 𝐢𝐦𝐩𝐫𝐢𝐧𝐭𝐢𝐧𝐠 𝐝𝐢𝐬𝐨𝐫𝐝𝐞𝐫
This epigenome editing makes a difference for all genomic scientists, especially those who are scratching their heads trying to design effective gene therapies.
#epigenetics #CRISPR #genomics
This epigenome editing makes a difference for all genomic scientists, especially those who are scratching their heads trying to design effective gene therapies.
#epigenetics #CRISPR #genomics
February 20, 2025 at 4:43 PM
𝐂𝐑𝐈𝐒𝐏𝐑-𝐛𝐚𝐬𝐞𝐝 𝐞𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐞 𝐞𝐝𝐢𝐭𝐢𝐧𝐠 𝐮𝐧𝐜𝐨𝐯𝐞𝐫𝐬 𝐭𝐡𝐞 𝐦𝐢𝐬𝐬𝐢𝐧𝐠 𝐥𝐢𝐧𝐤𝐬 𝐢𝐧 𝐠𝐞𝐧𝐨𝐦𝐢𝐜 𝐢𝐦𝐩𝐫𝐢𝐧𝐭𝐢𝐧𝐠 𝐝𝐢𝐬𝐨𝐫𝐝𝐞𝐫
This epigenome editing makes a difference for all genomic scientists, especially those who are scratching their heads trying to design effective gene therapies.
#epigenetics #CRISPR #genomics
This epigenome editing makes a difference for all genomic scientists, especially those who are scratching their heads trying to design effective gene therapies.
#epigenetics #CRISPR #genomics
𝐀 𝐩𝐨𝐭𝐞𝐧𝐭𝐢𝐚𝐥 𝐤𝐞𝐲 𝐩𝐫𝐞𝐝𝐢𝐜𝐭𝐨𝐫 𝐨𝐟 𝐭𝐮𝐦𝐨𝐮𝐫 𝐚𝐠𝐠𝐫𝐞𝐬𝐬𝐢𝐯𝐞𝐧𝐞𝐬𝐬 𝐢𝐧 𝐩𝐫𝐞𝐜𝐢𝐬𝐢𝐨𝐧 𝐨𝐧𝐜𝐨𝐥𝐨𝐠𝐲: 𝐑𝐍𝐀 𝐏𝐨𝐥𝐲𝐦𝐞𝐫𝐚𝐬𝐞 𝐈𝐈 𝐨𝐜𝐜𝐮𝐩𝐚𝐧𝐜𝐲 𝐚𝐭 𝐡𝐢𝐬𝐭𝐨𝐧𝐞 𝐠𝐞𝐧𝐞𝐬?
Cancer has an increased tendency to accumulate genomic alterations, a phenomenon scientists call "𝐠𝐞𝐧𝐨𝐦𝐢𝐜 𝐢𝐧𝐬𝐭𝐚𝐛𝐢𝐥𝐢𝐭𝐲".
#epigenetics #cancer #genomics
Cancer has an increased tendency to accumulate genomic alterations, a phenomenon scientists call "𝐠𝐞𝐧𝐨𝐦𝐢𝐜 𝐢𝐧𝐬𝐭𝐚𝐛𝐢𝐥𝐢𝐭𝐲".
#epigenetics #cancer #genomics
February 16, 2025 at 1:53 PM
𝐀 𝐩𝐨𝐭𝐞𝐧𝐭𝐢𝐚𝐥 𝐤𝐞𝐲 𝐩𝐫𝐞𝐝𝐢𝐜𝐭𝐨𝐫 𝐨𝐟 𝐭𝐮𝐦𝐨𝐮𝐫 𝐚𝐠𝐠𝐫𝐞𝐬𝐬𝐢𝐯𝐞𝐧𝐞𝐬𝐬 𝐢𝐧 𝐩𝐫𝐞𝐜𝐢𝐬𝐢𝐨𝐧 𝐨𝐧𝐜𝐨𝐥𝐨𝐠𝐲: 𝐑𝐍𝐀 𝐏𝐨𝐥𝐲𝐦𝐞𝐫𝐚𝐬𝐞 𝐈𝐈 𝐨𝐜𝐜𝐮𝐩𝐚𝐧𝐜𝐲 𝐚𝐭 𝐡𝐢𝐬𝐭𝐨𝐧𝐞 𝐠𝐞𝐧𝐞𝐬?
Cancer has an increased tendency to accumulate genomic alterations, a phenomenon scientists call "𝐠𝐞𝐧𝐨𝐦𝐢𝐜 𝐢𝐧𝐬𝐭𝐚𝐛𝐢𝐥𝐢𝐭𝐲".
#epigenetics #cancer #genomics
Cancer has an increased tendency to accumulate genomic alterations, a phenomenon scientists call "𝐠𝐞𝐧𝐨𝐦𝐢𝐜 𝐢𝐧𝐬𝐭𝐚𝐛𝐢𝐥𝐢𝐭𝐲".
#epigenetics #cancer #genomics
𝐂𝐚𝐧𝐜𝐞𝐫 𝐢𝐧𝐡𝐮𝐦𝐚𝐧𝐞: 𝐖𝐡𝐲 𝐝𝐨 𝐦𝐚𝐥𝐢𝐠𝐧𝐚𝐧𝐭 𝐞𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐞𝐬 𝐝𝐞𝐟𝐲 𝐡𝐮𝐦𝐚𝐧 𝐥𝐨𝐠𝐢𝐜?
Cancer is simply inhuman.
Why can a single, mutated cell become a life-threatening danger to a human being?
How can it destroy the entire organism, it belongs to.
#epigenetics #cancer #genomics
Cancer is simply inhuman.
Why can a single, mutated cell become a life-threatening danger to a human being?
How can it destroy the entire organism, it belongs to.
#epigenetics #cancer #genomics
February 9, 2025 at 7:04 PM
𝐂𝐚𝐧𝐜𝐞𝐫 𝐢𝐧𝐡𝐮𝐦𝐚𝐧𝐞: 𝐖𝐡𝐲 𝐝𝐨 𝐦𝐚𝐥𝐢𝐠𝐧𝐚𝐧𝐭 𝐞𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐞𝐬 𝐝𝐞𝐟𝐲 𝐡𝐮𝐦𝐚𝐧 𝐥𝐨𝐠𝐢𝐜?
Cancer is simply inhuman.
Why can a single, mutated cell become a life-threatening danger to a human being?
How can it destroy the entire organism, it belongs to.
#epigenetics #cancer #genomics
Cancer is simply inhuman.
Why can a single, mutated cell become a life-threatening danger to a human being?
How can it destroy the entire organism, it belongs to.
#epigenetics #cancer #genomics
𝐂𝐞𝐥𝐥𝐮𝐥𝐚𝐫 𝐛𝐥𝐚𝐜𝐤 𝐛𝐨𝐱: 𝐈𝐬 𝐞𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜𝐬 𝐭𝐡𝐞 𝐚𝐧𝐬𝐰𝐞𝐫 𝐭𝐨 𝐰𝐡𝐲 𝐨𝐧𝐥𝐲 𝐬𝐨𝐦𝐞 𝐜𝐞𝐥𝐥𝐬 𝐛𝐞𝐜𝐨𝐦𝐞 𝐦𝐚𝐥𝐢𝐠𝐧𝐚𝐧𝐭?
It might sound a bit puzzling...
But not every cell with a specific set of oncogenic mutations actually transforms into a cancerous cell.
#epigenetics #cancer #genomics
It might sound a bit puzzling...
But not every cell with a specific set of oncogenic mutations actually transforms into a cancerous cell.
#epigenetics #cancer #genomics
February 7, 2025 at 10:04 AM
𝐂𝐞𝐥𝐥𝐮𝐥𝐚𝐫 𝐛𝐥𝐚𝐜𝐤 𝐛𝐨𝐱: 𝐈𝐬 𝐞𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜𝐬 𝐭𝐡𝐞 𝐚𝐧𝐬𝐰𝐞𝐫 𝐭𝐨 𝐰𝐡𝐲 𝐨𝐧𝐥𝐲 𝐬𝐨𝐦𝐞 𝐜𝐞𝐥𝐥𝐬 𝐛𝐞𝐜𝐨𝐦𝐞 𝐦𝐚𝐥𝐢𝐠𝐧𝐚𝐧𝐭?
It might sound a bit puzzling...
But not every cell with a specific set of oncogenic mutations actually transforms into a cancerous cell.
#epigenetics #cancer #genomics
It might sound a bit puzzling...
But not every cell with a specific set of oncogenic mutations actually transforms into a cancerous cell.
#epigenetics #cancer #genomics
𝐀 𝐛𝐥𝐮𝐞𝐩𝐫𝐢𝐧𝐭 𝐟𝐨𝐫 𝐡𝐮𝐦𝐚𝐧 𝐭𝐡𝐨𝐮𝐠𝐡𝐭: 𝐓𝐫𝐚𝐧𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧 𝐟𝐚𝐜𝐭𝐨𝐫𝐬 & 𝐧𝐞𝐮𝐫𝐨𝐧𝐚𝐥 𝐚𝐜𝐭𝐢𝐯𝐢𝐭𝐲-𝐝𝐞𝐩𝐞𝐧𝐝𝐞𝐧𝐭 𝐠𝐞𝐧𝐞𝐬.
Even things as complex as thinking, forming memories, or making logical connections all come down to how our genes react to different stimuli.
#epigenetics #genomics #science
Even things as complex as thinking, forming memories, or making logical connections all come down to how our genes react to different stimuli.
#epigenetics #genomics #science
February 4, 2025 at 11:38 AM
𝐀 𝐛𝐥𝐮𝐞𝐩𝐫𝐢𝐧𝐭 𝐟𝐨𝐫 𝐡𝐮𝐦𝐚𝐧 𝐭𝐡𝐨𝐮𝐠𝐡𝐭: 𝐓𝐫𝐚𝐧𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧 𝐟𝐚𝐜𝐭𝐨𝐫𝐬 & 𝐧𝐞𝐮𝐫𝐨𝐧𝐚𝐥 𝐚𝐜𝐭𝐢𝐯𝐢𝐭𝐲-𝐝𝐞𝐩𝐞𝐧𝐝𝐞𝐧𝐭 𝐠𝐞𝐧𝐞𝐬.
Even things as complex as thinking, forming memories, or making logical connections all come down to how our genes react to different stimuli.
#epigenetics #genomics #science
Even things as complex as thinking, forming memories, or making logical connections all come down to how our genes react to different stimuli.
#epigenetics #genomics #science
𝐃𝐞𝐜𝐨𝐝𝐢𝐧𝐠 𝐌𝐞𝐧𝐝𝐞𝐥𝐢𝐚𝐧 𝐜𝐨𝐧𝐝𝐢𝐭𝐢𝐨𝐧𝐬 𝐰𝐢𝐭𝐡 𝐦𝐮𝐥𝐭𝐢-𝐨𝐦𝐢𝐜𝐬: 𝐂𝐨𝐮𝐥𝐝 𝐢𝐭 𝐛𝐞𝐜𝐨𝐦𝐞 𝐭𝐡𝐞 𝐠𝐨𝐥𝐝 𝐬𝐭𝐚𝐧𝐝𝐚𝐫𝐝 𝐢𝐧 𝐜𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐠𝐞𝐧𝐞𝐭𝐢𝐜𝐬?
I love seeing more cases like this one from 𝘕𝘢𝘵𝘶𝘳𝘦 𝘎𝘦𝘯𝘦𝘵𝘪𝘤𝘴 journal.
#epigenetics #genomics #multiomics
I love seeing more cases like this one from 𝘕𝘢𝘵𝘶𝘳𝘦 𝘎𝘦𝘯𝘦𝘵𝘪𝘤𝘴 journal.
#epigenetics #genomics #multiomics
February 2, 2025 at 5:27 PM
𝐃𝐞𝐜𝐨𝐝𝐢𝐧𝐠 𝐌𝐞𝐧𝐝𝐞𝐥𝐢𝐚𝐧 𝐜𝐨𝐧𝐝𝐢𝐭𝐢𝐨𝐧𝐬 𝐰𝐢𝐭𝐡 𝐦𝐮𝐥𝐭𝐢-𝐨𝐦𝐢𝐜𝐬: 𝐂𝐨𝐮𝐥𝐝 𝐢𝐭 𝐛𝐞𝐜𝐨𝐦𝐞 𝐭𝐡𝐞 𝐠𝐨𝐥𝐝 𝐬𝐭𝐚𝐧𝐝𝐚𝐫𝐝 𝐢𝐧 𝐜𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐠𝐞𝐧𝐞𝐭𝐢𝐜𝐬?
I love seeing more cases like this one from 𝘕𝘢𝘵𝘶𝘳𝘦 𝘎𝘦𝘯𝘦𝘵𝘪𝘤𝘴 journal.
#epigenetics #genomics #multiomics
I love seeing more cases like this one from 𝘕𝘢𝘵𝘶𝘳𝘦 𝘎𝘦𝘯𝘦𝘵𝘪𝘤𝘴 journal.
#epigenetics #genomics #multiomics
𝐆𝐞𝐧𝐨𝐦𝐞-𝐒𝐡𝐮𝐟𝐟𝐥𝐞-𝐬𝐞𝐪: 𝐒𝐭𝐮𝐝𝐲𝐢𝐧𝐠 𝐭𝐡𝐞 𝐟𝐮𝐧𝐜𝐭𝐢𝐨𝐧𝐚𝐥 𝐜𝐨𝐧𝐬𝐞𝐪𝐮𝐞𝐧𝐜𝐞𝐬 𝐨𝐟 𝐬𝐭𝐫𝐮𝐜𝐭𝐮𝐫𝐚𝐥 𝐯𝐚𝐫𝐢𝐚𝐧𝐭𝐬 (𝐒𝐕) 𝐚𝐭 𝐬𝐜𝐚𝐥𝐞
It's seriously impressive to see a method such powerful that can generate thousands of structural variants (in both human & mouse genomes) all in one experiment.
#genomics #sequencing
It's seriously impressive to see a method such powerful that can generate thousands of structural variants (in both human & mouse genomes) all in one experiment.
#genomics #sequencing
February 1, 2025 at 3:22 PM
𝐆𝐞𝐧𝐨𝐦𝐞-𝐒𝐡𝐮𝐟𝐟𝐥𝐞-𝐬𝐞𝐪: 𝐒𝐭𝐮𝐝𝐲𝐢𝐧𝐠 𝐭𝐡𝐞 𝐟𝐮𝐧𝐜𝐭𝐢𝐨𝐧𝐚𝐥 𝐜𝐨𝐧𝐬𝐞𝐪𝐮𝐞𝐧𝐜𝐞𝐬 𝐨𝐟 𝐬𝐭𝐫𝐮𝐜𝐭𝐮𝐫𝐚𝐥 𝐯𝐚𝐫𝐢𝐚𝐧𝐭𝐬 (𝐒𝐕) 𝐚𝐭 𝐬𝐜𝐚𝐥𝐞
It's seriously impressive to see a method such powerful that can generate thousands of structural variants (in both human & mouse genomes) all in one experiment.
#genomics #sequencing
It's seriously impressive to see a method such powerful that can generate thousands of structural variants (in both human & mouse genomes) all in one experiment.
#genomics #sequencing
𝐇𝐨𝐰 𝐝𝐨𝐞𝐬 𝐜𝐡𝐫𝐨𝐦𝐚𝐭𝐢𝐧 𝐬𝐡𝐚𝐩𝐞 𝐄𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐞 𝐟𝐮𝐧𝐜𝐭𝐢𝐨𝐧?
If anyone asked me how complex the field of Epigenetics is…
I'd say it's mind-bogglingly complicated.
There are a few reasons for that.
#epigenetics #genomics
If anyone asked me how complex the field of Epigenetics is…
I'd say it's mind-bogglingly complicated.
There are a few reasons for that.
#epigenetics #genomics
January 31, 2025 at 4:03 PM
𝐇𝐨𝐰 𝐝𝐨𝐞𝐬 𝐜𝐡𝐫𝐨𝐦𝐚𝐭𝐢𝐧 𝐬𝐡𝐚𝐩𝐞 𝐄𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐞 𝐟𝐮𝐧𝐜𝐭𝐢𝐨𝐧?
If anyone asked me how complex the field of Epigenetics is…
I'd say it's mind-bogglingly complicated.
There are a few reasons for that.
#epigenetics #genomics
If anyone asked me how complex the field of Epigenetics is…
I'd say it's mind-bogglingly complicated.
There are a few reasons for that.
#epigenetics #genomics
𝐀 𝐠𝐞𝐧𝐨𝐦𝐞-𝐰𝐢𝐝𝐞 𝐚𝐭𝐥𝐚𝐬 𝐨𝐟 𝐡𝐮𝐦𝐚𝐧 𝐜𝐞𝐥𝐥 𝐦𝐨𝐫𝐩𝐡𝐨𝐥𝐨𝐠𝐲
Have I mentioned before that the future of functional (epi)genomics is probably going to be 𝐨𝐩𝐭𝐢𝐜𝐚𝐥 𝐩𝐨𝐨𝐥𝐞𝐝 𝐬𝐜𝐫𝐞𝐞𝐧𝐢𝐧𝐠?
If not, I'll say it again:
#epigenetics #genomics
Have I mentioned before that the future of functional (epi)genomics is probably going to be 𝐨𝐩𝐭𝐢𝐜𝐚𝐥 𝐩𝐨𝐨𝐥𝐞𝐝 𝐬𝐜𝐫𝐞𝐞𝐧𝐢𝐧𝐠?
If not, I'll say it again:
#epigenetics #genomics
January 30, 2025 at 8:14 PM
𝐀 𝐠𝐞𝐧𝐨𝐦𝐞-𝐰𝐢𝐝𝐞 𝐚𝐭𝐥𝐚𝐬 𝐨𝐟 𝐡𝐮𝐦𝐚𝐧 𝐜𝐞𝐥𝐥 𝐦𝐨𝐫𝐩𝐡𝐨𝐥𝐨𝐠𝐲
Have I mentioned before that the future of functional (epi)genomics is probably going to be 𝐨𝐩𝐭𝐢𝐜𝐚𝐥 𝐩𝐨𝐨𝐥𝐞𝐝 𝐬𝐜𝐫𝐞𝐞𝐧𝐢𝐧𝐠?
If not, I'll say it again:
#epigenetics #genomics
Have I mentioned before that the future of functional (epi)genomics is probably going to be 𝐨𝐩𝐭𝐢𝐜𝐚𝐥 𝐩𝐨𝐨𝐥𝐞𝐝 𝐬𝐜𝐫𝐞𝐞𝐧𝐢𝐧𝐠?
If not, I'll say it again:
#epigenetics #genomics
𝐖𝐚𝐧𝐭 𝐚 𝐧𝐨-𝐣𝐮𝐝𝐠𝐦𝐞𝐧𝐭, 𝐛𝐨𝐝𝐲-𝐰𝐢𝐝𝐞 𝐛𝐫𝐞𝐚𝐤𝐝𝐨𝐰𝐧 𝐨𝐟 𝐲𝐨𝐮𝐫 𝐧𝐚𝐧𝐨𝐦𝐞𝐝𝐢𝐜𝐢𝐧𝐞 𝐚𝐭 𝐭𝐡𝐞 𝐜𝐞𝐥𝐥𝐮𝐥𝐚𝐫 𝐥𝐞𝐯𝐞𝐥? 𝐋𝐨𝐨𝐤 𝐧𝐨 𝐟𝐮𝐫𝐭𝐡𝐞𝐫.
They say 90% of clinical trials fail for one simple reason:
• Scientists are great at designing drugs, inventing fancy delivery systems & manufacturing them…
#science #nanotechnology #research
They say 90% of clinical trials fail for one simple reason:
• Scientists are great at designing drugs, inventing fancy delivery systems & manufacturing them…
#science #nanotechnology #research
January 18, 2025 at 10:43 AM
𝐖𝐚𝐧𝐭 𝐚 𝐧𝐨-𝐣𝐮𝐝𝐠𝐦𝐞𝐧𝐭, 𝐛𝐨𝐝𝐲-𝐰𝐢𝐝𝐞 𝐛𝐫𝐞𝐚𝐤𝐝𝐨𝐰𝐧 𝐨𝐟 𝐲𝐨𝐮𝐫 𝐧𝐚𝐧𝐨𝐦𝐞𝐝𝐢𝐜𝐢𝐧𝐞 𝐚𝐭 𝐭𝐡𝐞 𝐜𝐞𝐥𝐥𝐮𝐥𝐚𝐫 𝐥𝐞𝐯𝐞𝐥? 𝐋𝐨𝐨𝐤 𝐧𝐨 𝐟𝐮𝐫𝐭𝐡𝐞𝐫.
They say 90% of clinical trials fail for one simple reason:
• Scientists are great at designing drugs, inventing fancy delivery systems & manufacturing them…
#science #nanotechnology #research
They say 90% of clinical trials fail for one simple reason:
• Scientists are great at designing drugs, inventing fancy delivery systems & manufacturing them…
#science #nanotechnology #research