Chris Kyriazis
@ckyriazis.bsky.social
Postdoc at the San Diego Zoo Wildlife Alliance interested in population genetics & conservation genomics https://chriskyriazis.weebly.com/
Pinned
Chris Kyriazis
@ckyriazis.bsky.social
· Aug 4
I am thrilled to share this paper outlining some ideas I’ve been thinking about for a little while on a simple but powerful approach for predicting risk of inbreeding depression from long runs of homozygosity and non-ROH heterozygosity. 1/n @klohmueller.bsky.social doi.org/10.1016/j.tr...
Reposted by Chris Kyriazis
For population genetics and evolutionary biology folks in the Bay Area: the next BAPG will be hosted by Stanford CEHG and the Petrov lab at Stanford on 12/6.
Registration is free but required. The deadline for talk submission is Nov. 16. Hope to see you soon! Pls RT!
docs.google.com/forms/d/e/1F...
Registration is free but required. The deadline for talk submission is Nov. 16. Hope to see you soon! Pls RT!
docs.google.com/forms/d/e/1F...
docs.google.com
October 20, 2025 at 10:42 PM
For population genetics and evolutionary biology folks in the Bay Area: the next BAPG will be hosted by Stanford CEHG and the Petrov lab at Stanford on 12/6.
Registration is free but required. The deadline for talk submission is Nov. 16. Hope to see you soon! Pls RT!
docs.google.com/forms/d/e/1F...
Registration is free but required. The deadline for talk submission is Nov. 16. Hope to see you soon! Pls RT!
docs.google.com/forms/d/e/1F...
Reposted by Chris Kyriazis
Apply for our PhD program on Evolution Ecology Organismal Biology (Integrative! Biology)
Dec 1 2025 deadline
Check out the Flyer below for more information on our #MOILAB!
Link to Flyer
docs.google.com/document/d/1...
@ucberkeleyofficial.bsky.social
@hhmi.org
Dec 1 2025 deadline
Check out the Flyer below for more information on our #MOILAB!
Link to Flyer
docs.google.com/document/d/1...
@ucberkeleyofficial.bsky.social
@hhmi.org
October 13, 2025 at 8:08 PM
Apply for our PhD program on Evolution Ecology Organismal Biology (Integrative! Biology)
Dec 1 2025 deadline
Check out the Flyer below for more information on our #MOILAB!
Link to Flyer
docs.google.com/document/d/1...
@ucberkeleyofficial.bsky.social
@hhmi.org
Dec 1 2025 deadline
Check out the Flyer below for more information on our #MOILAB!
Link to Flyer
docs.google.com/document/d/1...
@ucberkeleyofficial.bsky.social
@hhmi.org
Reposted by Chris Kyriazis
In the midst of the darkness, I am pleased to announce that UCLA will be hosting the upcoming Southern California Evolutionary Genetics (SCalE) conference on November 1! Registration & abstract submission is here: www.scalemeeting.org/home Deadline is October 13! Hope to see you at UCLA!
Home
The SCalE Meeting is a free, one day regional academic meeting focused on evolutionary genetics and genomics.
This year's SCalE Meeting is hosted by UCLA, sponsored by the Institute for Quantitative ...
www.scalemeeting.org
September 16, 2025 at 4:47 PM
In the midst of the darkness, I am pleased to announce that UCLA will be hosting the upcoming Southern California Evolutionary Genetics (SCalE) conference on November 1! Registration & abstract submission is here: www.scalemeeting.org/home Deadline is October 13! Hope to see you at UCLA!
Reposted by Chris Kyriazis
New manuscript out today in @ecol-evol.bsky.social, led by my grad student Anais. We collated data from thousands of recent animal pop-gen studies to test 3 simple hypotheses: does genomic (1) diversity decrease (yes), (2) differentiation increase (yes), both with increased IUCN-endangerment?
September 15, 2025 at 6:42 PM
New manuscript out today in @ecol-evol.bsky.social, led by my grad student Anais. We collated data from thousands of recent animal pop-gen studies to test 3 simple hypotheses: does genomic (1) diversity decrease (yes), (2) differentiation increase (yes), both with increased IUCN-endangerment?
Reposted by Chris Kyriazis
Save the date! #PEQG26 June 9-12 2026 in Asilomar, CA. Happens only every 2yrs, but is my favorite conference. Full website coming soon, and registration and abstract submission opens November 14, but I'm allowed to tease that keynotes will be @jnovembre.bsky.social @jennytung.bsky.social and me!
Homepage - Population, Evolutionary, and Quantitative Genetics Conference
Visit our website to learn more.
genetics-gsa.org
September 3, 2025 at 6:51 PM
Save the date! #PEQG26 June 9-12 2026 in Asilomar, CA. Happens only every 2yrs, but is my favorite conference. Full website coming soon, and registration and abstract submission opens November 14, but I'm allowed to tease that keynotes will be @jnovembre.bsky.social @jennytung.bsky.social and me!
Reposted by Chris Kyriazis
Excited to share our new paper on genetic rescue in the Pacific pocket mouse! To conserve this endangered species, we sought to understand whether small populations at risk of outbreeding depression are better managed in isolation or with gene flow. @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Fitness benefits of genetic rescue despite chromosomal differences in an endangered pocket mouse
Two-thirds of Earth’s species have undergone population declines, leaving many vulnerable to genomic erosion and inbreeding depression. Genetic rescue can boost the fitness of small populations, but p...
www.science.org
August 21, 2025 at 8:03 PM
Excited to share our new paper on genetic rescue in the Pacific pocket mouse! To conserve this endangered species, we sought to understand whether small populations at risk of outbreeding depression are better managed in isolation or with gene flow. @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Chris Kyriazis
The Sudmant lab at UC Berkeley is seeking a postdoc to work on a fully funded NIH project to understand differences in DNA repair and somatic mutation across the primate tree of life. Please spread widely to those who may be interested aprecruit.berkeley.edu/JPF05052
Postdoctoral Scholar – Genomics, Aging, Somatic Mutation, Structural Variation, Evolution , Cancer – Integrative Biology
University of California, Berkeley is hiring. Apply now!
aprecruit.berkeley.edu
August 13, 2025 at 4:22 AM
The Sudmant lab at UC Berkeley is seeking a postdoc to work on a fully funded NIH project to understand differences in DNA repair and somatic mutation across the primate tree of life. Please spread widely to those who may be interested aprecruit.berkeley.edu/JPF05052
Reposted by Chris Kyriazis
SLiM 5: Eco-evolutionary simulations across multiple chromosomes and full genomes https://www.biorxiv.org/content/10.1101/2025.08.07.669155v1
August 11, 2025 at 9:32 PM
SLiM 5: Eco-evolutionary simulations across multiple chromosomes and full genomes https://www.biorxiv.org/content/10.1101/2025.08.07.669155v1
Reposted by Chris Kyriazis
Our manuscript describing the first Genomic History Inference Strategies Tournament is now on bioRxiv! Enjoy reading about the 2024 competition as you prepare your entries for the 2025 competition! ghi.st
GHIST 2024: The 1st Genomic History Inference Strategies Tournament
Evaluating population genetic inference methods is challenging due to the complexity of evolutionary histories, potential model misspecification, and unconscious biases in self-assessment. The Genomic...
doi.org
August 11, 2025 at 4:03 PM
Our manuscript describing the first Genomic History Inference Strategies Tournament is now on bioRxiv! Enjoy reading about the 2024 competition as you prepare your entries for the 2025 competition! ghi.st
Absolute insanity
August 8, 2025 at 5:40 PM
Absolute insanity
Reposted by Chris Kyriazis
I am thrilled to share this paper outlining some ideas I’ve been thinking about for a little while on a simple but powerful approach for predicting risk of inbreeding depression from long runs of homozygosity and non-ROH heterozygosity. 1/n @klohmueller.bsky.social doi.org/10.1016/j.tr...
August 4, 2025 at 5:10 PM
I am thrilled to share this paper outlining some ideas I’ve been thinking about for a little while on a simple but powerful approach for predicting risk of inbreeding depression from long runs of homozygosity and non-ROH heterozygosity. 1/n @klohmueller.bsky.social doi.org/10.1016/j.tr...
Reposted by Chris Kyriazis
*ALERT! GLOBAL GENETIC DIVERSITY TREND RE-ANALYSIS*
"Signals of consistent genetic diversity decline are not yet measurable in global meta-analysis" doi.org/10.1101/2025...
"Signals of consistent genetic diversity decline are not yet measurable in global meta-analysis" doi.org/10.1101/2025...
August 4, 2025 at 6:35 PM
*ALERT! GLOBAL GENETIC DIVERSITY TREND RE-ANALYSIS*
"Signals of consistent genetic diversity decline are not yet measurable in global meta-analysis" doi.org/10.1101/2025...
"Signals of consistent genetic diversity decline are not yet measurable in global meta-analysis" doi.org/10.1101/2025...
I am thrilled to share this paper outlining some ideas I’ve been thinking about for a little while on a simple but powerful approach for predicting risk of inbreeding depression from long runs of homozygosity and non-ROH heterozygosity. 1/n @klohmueller.bsky.social doi.org/10.1016/j.tr...
August 4, 2025 at 5:10 PM
I am thrilled to share this paper outlining some ideas I’ve been thinking about for a little while on a simple but powerful approach for predicting risk of inbreeding depression from long runs of homozygosity and non-ROH heterozygosity. 1/n @klohmueller.bsky.social doi.org/10.1016/j.tr...
Thanks to @evoisland.bsky.social for this nice Dispatch on our honeycreeper genomics paper: www.cell.com/current-biol...
Conservation genomics: Island birds on the brink
The Hawaiian honeycreepers are a striking example of bird evolution and a symbol of
the biodiversity crisis. A genomic analysis of two critically endangered honeycreeper
species reveals a bleak conser...
www.cell.com
July 25, 2025 at 6:41 PM
Thanks to @evoisland.bsky.social for this nice Dispatch on our honeycreeper genomics paper: www.cell.com/current-biol...
Reposted by Chris Kyriazis
My latest for @science.org looks into Colossal's claim that the plan to "resurrect" moa is "completely a Māori initiative" with Ngāi Tahu research centre, Te Tira Whakamātaki @nicrawlencenz.bsky.social
www.science.org/content/arti...
www.science.org/content/arti...
Effort to revive New Zealand’s extinct moa stirs controversy
Suggestions that nation’s Indigenous Māori wholeheartedly back project draws criticism
www.science.org
July 11, 2025 at 8:35 PM
My latest for @science.org looks into Colossal's claim that the plan to "resurrect" moa is "completely a Māori initiative" with Ngāi Tahu research centre, Te Tira Whakamātaki @nicrawlencenz.bsky.social
www.science.org/content/arti...
www.science.org/content/arti...
Some nice press coverage of our efforts to assemble the genome of the critically endangered palila with Hawaiian high school students and teachers:
www.hawaiinewsnow.com/2025/07/01/t...
www.hawaiinewsnow.com/2025/07/01/t...
Team of Hawaii students collaborates with scientists to draft endangered Palila bird genome
The palila once existed throughout the entire island chain. Now the species can only be found on a small region of Mauna Kea
www.hawaiinewsnow.com
July 1, 2025 at 9:50 PM
Some nice press coverage of our efforts to assemble the genome of the critically endangered palila with Hawaiian high school students and teachers:
www.hawaiinewsnow.com/2025/07/01/t...
www.hawaiinewsnow.com/2025/07/01/t...
Reposted by Chris Kyriazis
Another day testing the limits of resilience.
The Alexandria NSF building was designed for the NSF merit review process (gold standard), complete with a floor devoted to panels.
Now we aren’t allowed to have in person panels.
The loss of US science leadership will haunt this country for decades.
The Alexandria NSF building was designed for the NSF merit review process (gold standard), complete with a floor devoted to panels.
Now we aren’t allowed to have in person panels.
The loss of US science leadership will haunt this country for decades.
‘This is bull——”: National Science Foundation employees protest HUD's takeover
Dozens of National Science Foundation employees crowded the agency’s headquarters in Alexandria, Virginia, Wednesday to protest the news that the Department of Housing and Urban Development, or HUD, w...
www.nbcwashington.com
June 25, 2025 at 11:13 PM
Another day testing the limits of resilience.
The Alexandria NSF building was designed for the NSF merit review process (gold standard), complete with a floor devoted to panels.
Now we aren’t allowed to have in person panels.
The loss of US science leadership will haunt this country for decades.
The Alexandria NSF building was designed for the NSF merit review process (gold standard), complete with a floor devoted to panels.
Now we aren’t allowed to have in person panels.
The loss of US science leadership will haunt this country for decades.
Reposted by Chris Kyriazis
Climate change is expanding mosquito habitat in Hawaiʻi, threatening endangered birds with avian malaria.
So Hawaiʻi is releasing male mosquitoes with a strain of Wolbachia bacteria that make them incompatible with the females so their eggs don’t hatch. 🪶🧪
So Hawaiʻi is releasing male mosquitoes with a strain of Wolbachia bacteria that make them incompatible with the females so their eggs don’t hatch. 🪶🧪
Scientists are dropping live mosquitoes out of drones in Hawaii. Here’s why.
The wild reason why bird advocates are releasing these reviled insects from the sky.
www.vox.com
June 22, 2025 at 10:38 PM
Climate change is expanding mosquito habitat in Hawaiʻi, threatening endangered birds with avian malaria.
So Hawaiʻi is releasing male mosquitoes with a strain of Wolbachia bacteria that make them incompatible with the females so their eggs don’t hatch. 🪶🧪
So Hawaiʻi is releasing male mosquitoes with a strain of Wolbachia bacteria that make them incompatible with the females so their eggs don’t hatch. 🪶🧪
Reposted by Chris Kyriazis
Ferrari @jazlynmooney.bsky.social et al. find that while parameter scaling improves efficiency, strong scaling distorts diversity, intensifies background selection, and alters linkage patterns.
🔗 doi.org/10.1093/gbe/evaf097
#genome #evolution #bioinformatics
🔗 doi.org/10.1093/gbe/evaf097
#genome #evolution #bioinformatics
Parameter Scaling in Population Genetics Simulations may Introduce Unintended Background Selection: Considerations for Scaled Simulation Design
Abstract. Scaling is a common practice in population genetic simulations to increase computational efficiency. However, few studies systematically examine
doi.org
June 11, 2025 at 9:44 AM
Ferrari @jazlynmooney.bsky.social et al. find that while parameter scaling improves efficiency, strong scaling distorts diversity, intensifies background selection, and alters linkage patterns.
🔗 doi.org/10.1093/gbe/evaf097
#genome #evolution #bioinformatics
🔗 doi.org/10.1093/gbe/evaf097
#genome #evolution #bioinformatics
Reposted by Chris Kyriazis
Very excited to share the first paper from my postdoc at the San Diego Zoo Wildlife Alliance on the population genomics of recovery and extinction Hawaiian honeycreepers:
Paper: doi.org/10.1016/j.cu...
Press release: sandiegozoowildlifealliance.org/PR/hawaiian-...
@currentbiology.bsky.social
Paper: doi.org/10.1016/j.cu...
Press release: sandiegozoowildlifealliance.org/PR/hawaiian-...
@currentbiology.bsky.social
May 29, 2025 at 6:28 PM
Very excited to share the first paper from my postdoc at the San Diego Zoo Wildlife Alliance on the population genomics of recovery and extinction Hawaiian honeycreepers:
Paper: doi.org/10.1016/j.cu...
Press release: sandiegozoowildlifealliance.org/PR/hawaiian-...
@currentbiology.bsky.social
Paper: doi.org/10.1016/j.cu...
Press release: sandiegozoowildlifealliance.org/PR/hawaiian-...
@currentbiology.bsky.social
Reposted by Chris Kyriazis
Super excited to release a huge evolution project on the works for many years:
Evolution experiments synchronized across climates to understand rapid adaptation
Preprint: doi.org/10.1101/2025...
All data available: www.grene-net.org/data
#MOILAB
@ucberkeleyofficial.bsky.social
@hhmi.org
🧵👇
Evolution experiments synchronized across climates to understand rapid adaptation
Preprint: doi.org/10.1101/2025...
All data available: www.grene-net.org/data
#MOILAB
@ucberkeleyofficial.bsky.social
@hhmi.org
🧵👇
May 30, 2025 at 5:56 PM
Super excited to release a huge evolution project on the works for many years:
Evolution experiments synchronized across climates to understand rapid adaptation
Preprint: doi.org/10.1101/2025...
All data available: www.grene-net.org/data
#MOILAB
@ucberkeleyofficial.bsky.social
@hhmi.org
🧵👇
Evolution experiments synchronized across climates to understand rapid adaptation
Preprint: doi.org/10.1101/2025...
All data available: www.grene-net.org/data
#MOILAB
@ucberkeleyofficial.bsky.social
@hhmi.org
🧵👇
Very excited to share the first paper from my postdoc at the San Diego Zoo Wildlife Alliance on the population genomics of recovery and extinction Hawaiian honeycreepers:
Paper: doi.org/10.1016/j.cu...
Press release: sandiegozoowildlifealliance.org/PR/hawaiian-...
@currentbiology.bsky.social
Paper: doi.org/10.1016/j.cu...
Press release: sandiegozoowildlifealliance.org/PR/hawaiian-...
@currentbiology.bsky.social
May 29, 2025 at 6:28 PM
Very excited to share the first paper from my postdoc at the San Diego Zoo Wildlife Alliance on the population genomics of recovery and extinction Hawaiian honeycreepers:
Paper: doi.org/10.1016/j.cu...
Press release: sandiegozoowildlifealliance.org/PR/hawaiian-...
@currentbiology.bsky.social
Paper: doi.org/10.1016/j.cu...
Press release: sandiegozoowildlifealliance.org/PR/hawaiian-...
@currentbiology.bsky.social
Reposted by Chris Kyriazis
Awesome paper. Simple post-hoc trick (averaging over homologs) with elegant evolution theory dramatically improves zero shot coding variant effect prediction in pLMs & actually delivers better results from the larger models (inverting the trend with raw likelihoods). 1/
From Likelihood to Fitness: Improving Variant Effect Prediction in Protein and Genome Language Models https://www.biorxiv.org/content/10.1101/2025.05.20.655154v1
May 26, 2025 at 9:40 AM
Awesome paper. Simple post-hoc trick (averaging over homologs) with elegant evolution theory dramatically improves zero shot coding variant effect prediction in pLMs & actually delivers better results from the larger models (inverting the trend with raw likelihoods). 1/
Reposted by Chris Kyriazis
NSF Physics was cut by 85%, basically wiping out most of its capacity for supporting research.
NSF Astronomy was cut by 53%
Undergrad education was cut by 71% and research on learning by 79%
Graduate education was cut by 100% to ZERO.
#GiftLink ⚛️🔭
www.nytimes.com/interactive/...
NSF Astronomy was cut by 53%
Undergrad education was cut by 71% and research on learning by 79%
Graduate education was cut by 100% to ZERO.
#GiftLink ⚛️🔭
www.nytimes.com/interactive/...
Trump Has Cut Science Funding to Its Lowest Level in Decades (Gift Article)
The lag in funding extends far beyond D.E.I. initiatives, affecting almost every area of science: chemistry, computing, engineering, materials and more.
www.nytimes.com
May 22, 2025 at 3:34 PM
NSF Physics was cut by 85%, basically wiping out most of its capacity for supporting research.
NSF Astronomy was cut by 53%
Undergrad education was cut by 71% and research on learning by 79%
Graduate education was cut by 100% to ZERO.
#GiftLink ⚛️🔭
www.nytimes.com/interactive/...
NSF Astronomy was cut by 53%
Undergrad education was cut by 71% and research on learning by 79%
Graduate education was cut by 100% to ZERO.
#GiftLink ⚛️🔭
www.nytimes.com/interactive/...