Chang-Lin Chen, Ph.D.
@changlinc.bsky.social
Postdoc at Soft X-ray Tomography beamline, NSRRC, Taiwan
Interests: Mitochondrial dynamics, OXPHOS, Metabolisms
Interests: Mitochondrial dynamics, OXPHOS, Metabolisms
Reposted by Chang-Lin Chen, Ph.D.
Measuring mitochondrial membrane potential | The EMBO Journal www.embopress.org/doi/full/10....
Measuring mitochondrial membrane potential | The EMBO Journal
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
November 19, 2025 at 5:43 PM
Measuring mitochondrial membrane potential | The EMBO Journal www.embopress.org/doi/full/10....
Reposted by Chang-Lin Chen, Ph.D.
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cyclehttps://
www.sciencedirect.com/science/article/abs/pii/S1097276525008196
Congratulations @bensahralab.bsky.social !!
www.sciencedirect.com/science/article/abs/pii/S1097276525008196
Congratulations @bensahralab.bsky.social !!
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…
www.sciencedirect.com
October 29, 2025 at 5:23 AM
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cyclehttps://
www.sciencedirect.com/science/article/abs/pii/S1097276525008196
Congratulations @bensahralab.bsky.social !!
www.sciencedirect.com/science/article/abs/pii/S1097276525008196
Congratulations @bensahralab.bsky.social !!
Pleased to receive 1st prize poster award at TSMRM. Shared my work optimizing sample preparation for cryo-soft X-ray tomography and its application in mitochondrial structure studies.
Thanks to the organizers for an inspiring meeting and great to reconnect with friends from Japan.
#mitoresearch
Thanks to the organizers for an inspiring meeting and great to reconnect with friends from Japan.
#mitoresearch
October 29, 2025 at 8:54 AM
Pleased to receive 1st prize poster award at TSMRM. Shared my work optimizing sample preparation for cryo-soft X-ray tomography and its application in mitochondrial structure studies.
Thanks to the organizers for an inspiring meeting and great to reconnect with friends from Japan.
#mitoresearch
Thanks to the organizers for an inspiring meeting and great to reconnect with friends from Japan.
#mitoresearch
Using auxin-induced degron system in yeast, this study reveals that Fzo1 depletion causes abnormal mitochondrial inheritance and reduced mtDNA synthesis during the first cell division, worsening in subsequent divisions. It provides new insights into how Fzo1 loss leads to petite formation.
When mitochondria fall apart: Unbalanced mitochondrial segregation triggers loss of mtDNA in the absence of mitochondrial fusion https://www.biorxiv.org/content/10.1101/2025.05.13.653688v1
October 14, 2025 at 2:04 AM
Using auxin-induced degron system in yeast, this study reveals that Fzo1 depletion causes abnormal mitochondrial inheritance and reduced mtDNA synthesis during the first cell division, worsening in subsequent divisions. It provides new insights into how Fzo1 loss leads to petite formation.
Reposted by Chang-Lin Chen, Ph.D.
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
October 9, 2025 at 7:37 PM
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
Happy to share my first review article "The molecular mechanisms and physiological roles of mitochondria dynamics in Saccharomyces cerevisiae".
microbialcell.com/researcharti...
microbialcell.com/researcharti...
The molecular mechanisms and physiological roles of mitochondria dynamics in Saccharomyces cerevisiae
The molecular mechanisms and physiological roles of mitochondria dynamics in Saccharomyces cerevisiae –
For full text please see pdf.
microbialcell.com
August 28, 2025 at 5:58 AM
Happy to share my first review article "The molecular mechanisms and physiological roles of mitochondria dynamics in Saccharomyces cerevisiae".
microbialcell.com/researcharti...
microbialcell.com/researcharti...
Reposted by Chang-Lin Chen, Ph.D.
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 21, 2025 at 5:19 AM
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Had an amazing time conducting research at Osaka University! Grateful for the support and experiences, thanks for featuring my story! (Graduated in 2023)
www.sci.osaka-u.ac.jp/en/chang-lin...
www.sci.osaka-u.ac.jp/en/chang-lin...
THE UNIVERSITY OF OSAKA School of Science
“Science” covers all natural sciences and contributes to culture and happiness of the human through studies of basic science.
www.sci.osaka-u.ac.jp
June 16, 2025 at 8:43 AM
Had an amazing time conducting research at Osaka University! Grateful for the support and experiences, thanks for featuring my story! (Graduated in 2023)
www.sci.osaka-u.ac.jp/en/chang-lin...
www.sci.osaka-u.ac.jp/en/chang-lin...