Author | Lightnews

Reposted by Carmen Buchrieser

Institut Pasteur | 130 years of biomedical research @pasteur.fr · 8d

🇬🇧🇫🇷 "By working together we can overcome challenges faster"

Pasteur Foundation UK launched the formal @institutpasteur x @ox.ac.uk partnership in London.

From climate to AMR, cross-border collaboration is science's engine.
↘️ www.pasteurfoundation.uk/pasteur-oxfo...

In Conversation "science knows no country": Professor Sir Stewart Cole and Professor Dame Angela McLean.
©Pasteur Foundation UK

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FEMS Journals @femsjournals.bsky.social · 22d

De-DUFing the DUFs 🧩 @franznarberhaus.bsky.social lab uncovers how small DUF1127 proteins regulate #phosphate uptake by binding the sensor kinase PhoR. Their conserved role from Agrobacterium to E. coli highlights how even small DUFs can shape bacterial physiology 🦠
buff.ly/jJd9Eho

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Pedro Escoll @pescoll.bsky.social · 26d

Thus, single-cell metabolic dynamics can forecast infection outcomes. In the spirit of @stephenwolfram.bsky.social's ideas, bacterial infection exhibits pockets of computational reducibility at the single-cell scale. Might this point to new ways to predict infection progression?

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Pedro Escoll @pescoll.bsky.social · 26d

So we trained an explainable Machine Learning model using Δψm + mROS dynamics, and the AI model predicted which infected cell will support replication with 83% accuracy before bacterial replication begins

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Pedro Escoll @pescoll.bsky.social · 26d

What make these permissive macrophages different? Before bacteria replicate, macrophages that will permit bacterial growth already show sustained mitochondrial membrane potential (Δψm) and higher mitochondrial ROS (mROS). These are early mitochondrial signals of permissive cells!

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Pedro Escoll @pescoll.bsky.social · 26d

We tracked thousands of living primary human macrophages during infection with Legionella pneumophila, using high-throughput live imaging + our BATLI backtracking software. Legionella only replicates in ~20% infected primary macrophages!
www.nature.com/articles/s41...

Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages - Nature Communications

Computational models can help to explain the dynamics of cellular infection with pathogens. Here the authors use computational models to assess the single cell infection parameters of human macrophage...

www.nature.com

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Pedro Escoll @pescoll.bsky.social · 26d

New paper finally out on @natcomms.nature.com! Led by first author Maria Dramé with the collaboration of Francisco Garcia, @cbuch.bsky.social and @jytinevez.bsky.social at @pasteur.fr. Early mitochondrial signals in single human macrophages predict later Legionella replication. Link + details👇🧵

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FEMS Journals @femsjournals.bsky.social · Oct 4

Some #Pseudomonas aeruginosa strains naturally lack the major virulence system T3SS. 🦠 @inaattree.bsky.social & @cbuch.bsky.social labs reveal that avirulent isolates still produce valuable metabolites (e.g. rhamnolipids, elastase, pyoverdine)—making them promising for #biotech use.
buff.ly/JST7ZR1

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Jean-Yves Tinevez @jytinevez.bsky.social · Sep 10

Save the date! The @pasteur.fr Pasteur course on image analysis is announced:

It will happen from the 1st of June to the 5th 2026.

This year there will be only one track: the Early Career Investigator track (beginners). 👇

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Didier Mazel @amazeld.bsky.social · Sep 19

I am so proud to be part of this work, that we initiated Fernando de la Cruz and I, when he was on sabbatical in my lab in 2009... it took so much time for this achievement, 1000 thanks to Raúl Fernández-López! this brought me back to my PhD on cyanobacteria genetics. www.pnas.org/doi/10.1073/...

Mutations in the circadian cycle drive adaptive plasticity in cyanobacteria | PNAS

Circadian clocks allow organisms to anticipate daily fluctuations in light and temperature, but how this anticipatory role promotes adaptation to d...

www.pnas.org

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Sigolène Meilhac @meilhacsigolene.bsky.social · Sep 24

New publication | Science Advances www.science.org/doi/10.1126/...

Plasticity of ventricle position after heart looping in heterotaxy with right isomerism

The left/right position of ventricles needs to be maintained after heart looping, an unexpected step affected in heterotaxy.

www.science.org

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Infect-Net @infect-net.bsky.social · Sep 23

🔎 Find us at the 77th #DGHM Meeting in #Jena! Gabriele Pradel, Anja Lührmann, Sandra Reuter, Bärbel Stecher and others are happy to tell you more about our German network for women in infection research! 💜
👩‍🔬@gabrielepradel.bsky.social @sandrareuter.bsky.social @baerboletta.bsky.social

Die Infektionsforscherinnen Anja Lührmann, Sandra Reuter, Gabriele Pradel und Bärbel Stecher stehen stolz vor den Werbebannern von Infect-Net, Verband Deutscher Infektionsforscherinnen.

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FEMS Journals @femsjournals.bsky.social · Sep 27

Phages are promising against antibiotic-resistant bacteria—but resistance can emerge. 🦠 New work from @baerboletta.bsky.social lab shows E. coli can resist phages in the lab, but in the gut that resistance comes at a cost: context is crucial for #PhageTherapy success.
buff.ly/NLOjnE2

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Zamin Iqbal @zaminiqbal.bsky.social · Sep 25

Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n

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Enninga Lab @enningalab.bsky.social · Sep 18

🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫

Thread coming soon!

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · Sep 18

Nitrate-responsive Mycobacterial Intracytoplasmic Membranes dampen Inflammation during Mycobacterium tuberculosis Infection https://www.biorxiv.org/content/10.1101/2025.09.17.676823v1

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Géraldine Laloux @lalouxlab.bsky.social · Sep 17

🇪🇺 Smooth publishing experience with #microLife, the new @femsjournals.bsky.social journal of the European Academy for Microbiology.

🙏 @erc.europa.eu, F.R.S-FNRS & WEL-RI for support
4/4

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Géraldine Laloux @lalouxlab.bsky.social · Sep 17

🚨New paper out! #MicroSky
Studying obligate predators like Bdellovibrio bacteriovorus is tricky—essential genes for predation are also essential for survival.
We expanded its genetic toolbox:
🧬promoters to fine-tune expression
🧬IPTG-inducible system
🧬CRISPRi for rapid knockdown
bit.ly/46GUn2c
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Expanding the genetic toolbox of the obligate predatory bacterium Bdellovibrio bacteriovorus with inducible gene expression and CRISPR interference

Inducible gene expression and CRISPR interference-mediated depletion in the predatory bacterium Bdellovibrio bacteriovorus.

academic.oup.com

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Zeynep Baharoglu @zeynepbaharoglu.bsky.social · Sep 6

So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!

Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters

Uridine boosts aminoglycoside treatment efficiency against antibiotic-susceptible as well as antibiotic-resistant E. coli strains.

www.science.org

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Pedro Escoll @pescoll.bsky.social · Sep 5

New preprint in the lab! How the mitochondrial ETC works during infection of human macrophages with #Legionella or #Salmonella? Spoiler: there are some similarities and also pathogen-specific differences. Work led by Francisco Garcia and Paula Martínez, with @cbuch.bsky.social at @pasteur.fr

Figure 5. Working model for pathogen-specific ETC modulations that preserve the ∆ψm in hMDMs. (A) L. pneumophila: T4SS effectors dampen OxPhos early during
infection and preserve the ∆ψm by engaging the reverse mode of the FOF1 -ATPase. The ∆ψm remains high enough that ANT stays in forward mode, limiting cytosolic ATP
drain. All ETC complexes (I-IV) contribute to maintaining the ∆ψm. Complex I is uniquely essential during WT infection. (B) S. Typhimurium: T3SS SPI-1/2 effectors reduce
respiration and preserve the ∆ψm without inducing the reverse mode of the FO F1 -ATPase. Virulent bacteria rely on Complex I-driven electron entry with obligatory Complex
III/IV proton pumping, while Complex II contributes in all infection conditions. Secretion-defective mutants fail to establish the Complex I-dependent configuration.

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FEMS Journals @femsjournals.bsky.social · Aug 13

🔬 We’re past the midpoint of the year; perfect time to look back at what’s been discovered so far. From how Salmonella slows its escape from immune cells to the microbes thriving in oil reservoirs, these are the most-read #microLife papers of 2025 so far: buff.ly/TfhOvEc

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Andre @debattierbar.bsky.social · Aug 13

I was very honored to receive on of the Poster prizes at FEMS MICRO 2025 in Milan a few weeks back. It was such a great conference, heard so many interesting and stimulating talks & poster discussions.

FEMS Journals @femsjournals.bsky.social · Aug 7

🏆 Congratulations to the FEMS MICRO 2025 Poster Prize winners! 🎉
Editors from each of the FEMS Journals selected 7 outstanding posters based on their scientific excellence and impactful communication to celebrate microbiology research shaping the future. Learn more ➡️ buff.ly/4rhzIVS

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Ákos T Kovács @evolvedbiofilm.bsky.social · Aug 22

Avirulent Pseudomonas aeruginosa T3SS-negative strains belonging to Clade 5 produce variable quantities of secondary metabolites

@femsjournals.bsky.social #microLife from @inaattree.bsky.social
with @cbuch.bsky.social

academic.oup.com/microlife/ad...

Avirulent Pseudomonas aeruginosa T3SS-negative strains belonging to Clade 5 produce variable quantities of secondary metabolites

Abstract. Pseudomonas species are ubiquitous in the environment and serve as valuable source of enzymes and secondary metabolites for industrial applicatio

academic.oup.com

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Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · Jul 27

This 👇

Jerónimo Rodríguez-Beltrán @jerorb.bsky.social · Jul 25

🚨🚨 New paper in @narjournal.bsky.social! 🍾

Excludons are pairs of overlapping genes that block each other’s expression (basically, reverse operons).

We built a tool to identify them in bacterial genomes using transcriptomic data, in an awesome collab led by Iñigo Lasa and Álvaro San Martín.

👇

ExcludonFinder: mapping transcriptional overlaps between neighboring genes

Abstract. Bacteria regulate neighboring genes via overlapping transcription in untranslated regions (UTRs), forming excludons. This overlap leads to transc

academic.oup.com

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Lauren Palmer @laurenpalmer.bsky.social · Jul 25

Congratulations to 2025 GRC Microbial Adhesion and Signal Transduction Poster Award Winners!! 🎆🥂🙌 Thank you @cp-cell.bsky.social and @femsmicro.org for sponsoring!

From,
Your secret judges 🤫

Michael Patnode with Rachel Washburn, Jessica Aycock, and Mason Clark, winners of GRC MAST poster awards from Cell Press and FEMS

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Institut Pasteur | 130 years of biomedical research @pasteur.fr · Jul 16

Congratulations @cbuch.bsky.social ! 👏

FEMS @femsmicro.org · Jul 14

FEMS MICRO Milan 2025 is off to a great start with Prof. Carmen Buchrieser presenting her keynote on Legionella pneumophila and the fascinating ways this pathogen mimics eukaryotic cells.

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