Carlos Talavera-López
@cartalop.bsky.social
Director of Target Discovery Sciences at GSK
Computational biologist | Clinician
PhD @ki.se & @scilifelab.se
Postdoc @crick.ac.uk @sangerinstitute.bsky.social @ebi.embl.org @teichlab.bsky.social
I code in a suit | Nicaragüense | Childless cat lad
🇳🇮🇸🇪🇬🇧🇩🇪
Computational biologist | Clinician
PhD @ki.se & @scilifelab.se
Postdoc @crick.ac.uk @sangerinstitute.bsky.social @ebi.embl.org @teichlab.bsky.social
I code in a suit | Nicaragüense | Childless cat lad
🇳🇮🇸🇪🇬🇧🇩🇪
Reposted by Carlos Talavera-López
Even as the prices of these text snippets fall, better, more verbose models mean more tokens must be generated to complete a task
AI tokens are surging, but are profits?
The tech world’s new favourite measure comes with several caveats
econ.st
November 24, 2025 at 9:00 PM
Even as the prices of these text snippets fall, better, more verbose models mean more tokens must be generated to complete a task
Reposted by Carlos Talavera-López
Interesting finding on cancer lineage tracing for SCLC www.nature.com/articles/s41...
Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer - Nature
Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining neuroendocrine–tuft heterogeneity and offering new perspectives for targeting lineage plasticity.
www.nature.com
September 24, 2025 at 7:35 PM
Interesting finding on cancer lineage tracing for SCLC www.nature.com/articles/s41...
Reposted by Carlos Talavera-López
Nature’s Careers team spoke to a group of researchers about why they love LinkedIn, and how other scientists can use it to their advantage to harness its career-boosting and collaboration potential. #Academicsky 🧪
‘LinkedIn is like air to me’: the scientists who’ve cracked professional networking
Fans of the global social-media platform explain how best to harness its career-boosting and collaboration potential.
go.nature.com
September 14, 2025 at 4:08 PM
Nature’s Careers team spoke to a group of researchers about why they love LinkedIn, and how other scientists can use it to their advantage to harness its career-boosting and collaboration potential. #Academicsky 🧪
Reposted by Carlos Talavera-López
A pre-trained t-test transformer - www.nxn.se/p/a-pre-trai...
July 10, 2025 at 4:05 AM
A pre-trained t-test transformer - www.nxn.se/p/a-pre-trai...
Reposted by Carlos Talavera-López
One thing that really bothers me with the new "virtual cell" terminology is that it is currently largely focused on a very narrow definition of models that can predict effects of trans perturbations (gene dosage, drugs etc) on gene expression. 1/
June 28, 2025 at 10:38 AM
One thing that really bothers me with the new "virtual cell" terminology is that it is currently largely focused on a very narrow definition of models that can predict effects of trans perturbations (gene dosage, drugs etc) on gene expression. 1/
Reposted by Carlos Talavera-López
“SkinnyTok’s ruthless tone rings true to many women because they’re already being so ruthless toward themselves,” Annie Joy Williams writes:
When SkinnyTok Came for Me
The body positivity movement is over.
bit.ly
June 24, 2025 at 6:45 AM
“SkinnyTok’s ruthless tone rings true to many women because they’re already being so ruthless toward themselves,” Annie Joy Williams writes:
Reposted by Carlos Talavera-López
Ultraprocessed foods have "contributed to high rates of chronic disease in the United States"
They need to be regulated. @nejm.org today, the ways they can be reined in.
www.nejm.org/media/doi/fu...
They need to be regulated. @nejm.org today, the ways they can be reined in.
www.nejm.org/media/doi/fu...
Medical Media Center: New England Journal of Medicine
Much of the food consumed in the United States is ultraprocessed. Evidence indicates
that ultraprocessed food, as a class, has contributed to high rates of chronic diseases.
www.nejm.org
June 21, 2025 at 2:40 PM
Ultraprocessed foods have "contributed to high rates of chronic disease in the United States"
They need to be regulated. @nejm.org today, the ways they can be reined in.
www.nejm.org/media/doi/fu...
They need to be regulated. @nejm.org today, the ways they can be reined in.
www.nejm.org/media/doi/fu...
Reposted by Carlos Talavera-López
Let’s give a big round of applause to Jakob Jung, who has successfully defended his dissertation! 👏 Congratulations, @jabster93.bsky.social! The #HIRI family is celebrating with you! 🥳
Read more: www.helmholtz-hiri.de/en/newsroom/...
Read more: www.helmholtz-hiri.de/en/newsroom/...
June 5, 2025 at 2:43 PM
Let’s give a big round of applause to Jakob Jung, who has successfully defended his dissertation! 👏 Congratulations, @jabster93.bsky.social! The #HIRI family is celebrating with you! 🥳
Read more: www.helmholtz-hiri.de/en/newsroom/...
Read more: www.helmholtz-hiri.de/en/newsroom/...
Reposted by Carlos Talavera-López
Reposted by Carlos Talavera-López
The deadline for the VIB.AI group leader positions is approaching - send in your CV and short research plan before 14th June to start your BioML research lab in Leuven or Ghent
We want to connect:
To link model builders with data generators.
To bring together scientists asking why cells behave the way they do, and others figuring out how to model that behavior.
If you're working on AI in biology, consider joining!
https://tinyurl.com/y35m6khy
To link model builders with data generators.
To bring together scientists asking why cells behave the way they do, and others figuring out how to model that behavior.
If you're working on AI in biology, consider joining!
https://tinyurl.com/y35m6khy
June 4, 2025 at 7:16 AM
The deadline for the VIB.AI group leader positions is approaching - send in your CV and short research plan before 14th June to start your BioML research lab in Leuven or Ghent
Experiments in infrared photography.
📷 Bronica S2 & Nikkor-P 75mm f/2.8
🎞️ Ilford SPX 200
📷 Bronica S2 & Nikkor-P 75mm f/2.8
🎞️ Ilford SPX 200
June 1, 2025 at 5:36 AM
Experiments in infrared photography.
📷 Bronica S2 & Nikkor-P 75mm f/2.8
🎞️ Ilford SPX 200
📷 Bronica S2 & Nikkor-P 75mm f/2.8
🎞️ Ilford SPX 200
Reposted by Carlos Talavera-López
Personal news: I have been appointed by the rector of @helsinki.fi to a tenure-track associate prof position in Clinical Microbiology and Immunology! My affiliations are with the Faculty of Medicine and HiLIFE, Institute of Life Sciences @helsinki.fi . Humbled and excited to start this new journey!
May 27, 2025 at 5:27 AM
Personal news: I have been appointed by the rector of @helsinki.fi to a tenure-track associate prof position in Clinical Microbiology and Immunology! My affiliations are with the Faculty of Medicine and HiLIFE, Institute of Life Sciences @helsinki.fi . Humbled and excited to start this new journey!
Reposted by Carlos Talavera-López
Excited to be back at #eshg2025! Come by my poster today to check out fresh results on how rare high impact variants influence gene expression across immune cells—analyzed in 5,000 UK Biobank participants
Eva Holtkamp @evaholtkamp.bsky.social shares insights on rare variant effects on cell type-specific gene expression in immune cells across 4,978 UK Biobank participants - catch poster P18.066.A (Sunday, 1pm)
May 25, 2025 at 7:40 AM
Excited to be back at #eshg2025! Come by my poster today to check out fresh results on how rare high impact variants influence gene expression across immune cells—analyzed in 5,000 UK Biobank participants
Reposted by Carlos Talavera-López
A research team led from Stockholm University & @scilifelab.se has answered a long-standing question in cell biology, uncovering how the cell’s main energy currency, ATP, is transported into the endoplasmic reticulum (ER). The study is published in @nature.com.web.brid.gy
www.su.se/department-o...
www.su.se/department-o...
Scientists reveal how energy is delivered into the cells major “shipping port” - Department of Biochemistry and Biophysics
Scientists reveal how energy is delivered into the cells major “shipping port” - Department of Biochemistry and Biophysics
www.su.se
May 22, 2025 at 6:56 AM
A research team led from Stockholm University & @scilifelab.se has answered a long-standing question in cell biology, uncovering how the cell’s main energy currency, ATP, is transported into the endoplasmic reticulum (ER). The study is published in @nature.com.web.brid.gy
www.su.se/department-o...
www.su.se/department-o...
Reposted by Carlos Talavera-López
join us at ISMB iscb.bsky.social & @dreamchallenges.bsky.social - benchmarking foundation models w. @anshulkundaje.bsky.social @oldbap.bsky.social G. Stolovitzky @bowang87.bsky.social @mariabrbic.bsky.social K. Kalantar, J. Guinney supported by @ebi.embl.org @cziscience.bsky.social Tempus AI
May 16, 2025 at 11:23 AM
join us at ISMB iscb.bsky.social & @dreamchallenges.bsky.social - benchmarking foundation models w. @anshulkundaje.bsky.social @oldbap.bsky.social G. Stolovitzky @bowang87.bsky.social @mariabrbic.bsky.social K. Kalantar, J. Guinney supported by @ebi.embl.org @cziscience.bsky.social Tempus AI
Reposted by Carlos Talavera-López
Tissue-specific restriction of TE-derived regulatory elements safeguards cell-type identity https://www.biorxiv.org/content/10.1101/2025.05.13.653700v1
May 16, 2025 at 4:33 AM
Tissue-specific restriction of TE-derived regulatory elements safeguards cell-type identity https://www.biorxiv.org/content/10.1101/2025.05.13.653700v1
📷 Zorki-1 & Industar-22 50mm f/3.5
🎞️ Fujifilm Color 400
🎞️ Fujifilm Color 400
May 13, 2025 at 7:37 PM
📷 Zorki-1 & Industar-22 50mm f/3.5
🎞️ Fujifilm Color 400
🎞️ Fujifilm Color 400
Please! No more UMAPs/t-SNEs 👇👇👇
Here it is! Bonsai. Now there is really no more excuse for using t-SNE/UMAP. Bonsai not only makes cool pictures of your data. It actually rigorously preserves its structure. No tunable parameters. Incredible work by @dhdegroot.bsky.social.
I'm so excited about this!
www.biorxiv.org/content/10.1...
I'm so excited about this!
www.biorxiv.org/content/10.1...
Bonsai: Tree representations for distortion-free visualization and exploratory analysis of single-cell omics data
Single-cell omics methods promise to revolutionize our understanding of gene regulatory processes during cell differentiation, but analysis of such data continues to pose a major challenge. Apart from...
www.biorxiv.org
May 11, 2025 at 8:36 PM
Please! No more UMAPs/t-SNEs 👇👇👇
📷 Minolta Autocord I & Rokkor 75mm f/3.5
🎞️ Eastman Kodak double XX 250
🎞️ Eastman Kodak double XX 250
May 9, 2025 at 8:39 PM
📷 Minolta Autocord I & Rokkor 75mm f/3.5
🎞️ Eastman Kodak double XX 250
🎞️ Eastman Kodak double XX 250
📷 Nikon-F2 & Voigtländer Nokton 58mm f/1.4
🎞️ CineStill D50
🎞️ CineStill D50
May 9, 2025 at 4:33 AM
📷 Nikon-F2 & Voigtländer Nokton 58mm f/1.4
🎞️ CineStill D50
🎞️ CineStill D50
Reposted by Carlos Talavera-López
New preprint! My (now former) postdoc @kvastad.bsky.social led this integration of GWAS and spatial transcriptomics (ST) data to identify tissue structures with enrichment of disease-implicated genes = likely causal drivers of disease biology.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Spatial transcriptomics and genetically implicated genes identify putative causal tissue structures for complex traits
Spatially resolved transcriptomics is transforming our understanding of cellular and molecular diversity of tissues. Here, to identify tissue structures that are enriched for putatively causal disease...
www.biorxiv.org
May 5, 2025 at 3:40 PM
New preprint! My (now former) postdoc @kvastad.bsky.social led this integration of GWAS and spatial transcriptomics (ST) data to identify tissue structures with enrichment of disease-implicated genes = likely causal drivers of disease biology.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Carlos Talavera-López
Single molecule imaging reveals extracellular signal-regulated kinases dependent signal responsive spatial regulation of translation in cardiomyocytes https://www.biorxiv.org/content/10.1101/2025.05.05.652192v1
May 6, 2025 at 7:31 AM
Single molecule imaging reveals extracellular signal-regulated kinases dependent signal responsive spatial regulation of translation in cardiomyocytes https://www.biorxiv.org/content/10.1101/2025.05.05.652192v1
Reposted by Carlos Talavera-López
The ERC welcomes the offer of substantial additional budget from @ec.europa.eu for the development of a new ERC funding instrument offering larger, longer-term grants, as announced by President Ursula Von der Leyen at the Sorbonne this morning.
👉 europa.eu/!NTYTTV
👉 europa.eu/!NTYTTV
Choose Europe for Science: ERC welcomes new budget for 'super grants'
The Scientific Council of the European Research Council welcomes the offer of substantial additional budget from the European Commission for the development of a new ERC funding instrument offering la...
europa.eu
May 5, 2025 at 11:41 AM
The ERC welcomes the offer of substantial additional budget from @ec.europa.eu for the development of a new ERC funding instrument offering larger, longer-term grants, as announced by President Ursula Von der Leyen at the Sorbonne this morning.
👉 europa.eu/!NTYTTV
👉 europa.eu/!NTYTTV
Reposted by Carlos Talavera-López
Europe’s choice is clear.
To put science at the heart of its economy.
To become the home of scientific freedom and collaboration.
And to welcome talent from all over the world.
I’m glad to present the first elements of our Choose Europe Initiative.
→ europa.eu/!TTbWbJ
To put science at the heart of its economy.
To become the home of scientific freedom and collaboration.
And to welcome talent from all over the world.
I’m glad to present the first elements of our Choose Europe Initiative.
→ europa.eu/!TTbWbJ
May 5, 2025 at 10:00 AM
Europe’s choice is clear.
To put science at the heart of its economy.
To become the home of scientific freedom and collaboration.
And to welcome talent from all over the world.
I’m glad to present the first elements of our Choose Europe Initiative.
→ europa.eu/!TTbWbJ
To put science at the heart of its economy.
To become the home of scientific freedom and collaboration.
And to welcome talent from all over the world.
I’m glad to present the first elements of our Choose Europe Initiative.
→ europa.eu/!TTbWbJ