Caro Kobras 🐍
@carokobras.bsky.social
2024 BBSRC Fellow | University of Oxford | Junior Research Fellow at Linacre College | Investigating antibiotic resistance & tolerance, and better ways to kill pathogens 🧫
https://scholar.google.com/citations?hl=en&user=L2mEVzEAAAAJ
https://scholar.google.com/citations?hl=en&user=L2mEVzEAAAAJ
Pinned
Caro Kobras 🐍
@carokobras.bsky.social
· Apr 17
£9 million investment fuels groundbreaking bioscience research
From unlocking the secrets of animal movement to tackling antimicrobial resistance, UK’s brightest bioscience minds are pushing the boundaries of innovation.
www.ukri.org
Super excited to have been awarded a 2024 BBSRC Fellowship to investigate antibiotic tolerance in staphylococci! ☺️🧫🦠💊 @ukri.org
Very grateful for all the support I have received!!
www.ukri.org/news/9-milli...
Very grateful for all the support I have received!!
www.ukri.org/news/9-milli...
Reposted by Caro Kobras 🐍
Looking for an AMR-themed PhD project? Join us to investigate antibiotic tolerance in Staphylococcus aureus through a fully funded MRC DTP PhD studentship starting in September 2026.
This project is close collaboration with @kateduncan.bsky.social and @mycobacterium-ncl.bsky.social.
This project is close collaboration with @kateduncan.bsky.social and @mycobacterium-ncl.bsky.social.
MRC DiMeN Doctoral Training Partnership: Resensitisation of antibiotic-tolerant Staphylococcus aureus small colony variants at Newcastle University on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Resensitisation of antibiotic-tolerant Staphylococcus aureus small colony variants at Newcastle University, listed on FindAPhD.com
www.findaphd.com
November 1, 2025 at 11:11 AM
Looking for an AMR-themed PhD project? Join us to investigate antibiotic tolerance in Staphylococcus aureus through a fully funded MRC DTP PhD studentship starting in September 2026.
This project is close collaboration with @kateduncan.bsky.social and @mycobacterium-ncl.bsky.social.
This project is close collaboration with @kateduncan.bsky.social and @mycobacterium-ncl.bsky.social.
Reposted by Caro Kobras 🐍
Come and join our group in the new Life and Mind Building (lifeandmind.web.ox.ac.uk/home). POSTDOC: Bioinformatics/(meta)genomics :
tinyurl.com/2uhvvpn6
@ineosoxford.bsky.social @biology.ox.ac.uk @ox.ac.uk
tinyurl.com/2uhvvpn6
@ineosoxford.bsky.social @biology.ox.ac.uk @ox.ac.uk
October 31, 2025 at 4:23 PM
Come and join our group in the new Life and Mind Building (lifeandmind.web.ox.ac.uk/home). POSTDOC: Bioinformatics/(meta)genomics :
tinyurl.com/2uhvvpn6
@ineosoxford.bsky.social @biology.ox.ac.uk @ox.ac.uk
tinyurl.com/2uhvvpn6
@ineosoxford.bsky.social @biology.ox.ac.uk @ox.ac.uk
Reposted by Caro Kobras 🐍
New review - thanks to Markus Weingarth for the invitation! www.nature.com/articles/s41...
Client Challenge
www.nature.com
October 13, 2025 at 4:36 PM
New review - thanks to Markus Weingarth for the invitation! www.nature.com/articles/s41...
Reposted by Caro Kobras 🐍
Now published! www.nature.com/articles/s41...
Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.
Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.
September 29, 2025 at 2:24 PM
Now published! www.nature.com/articles/s41...
Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.
Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.
Reposted by Caro Kobras 🐍
Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
September 29, 2025 at 7:09 PM
Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Reposted by Caro Kobras 🐍
Dr Manuel Banzhaf
The Banzhaf group uses high-throughput methods to dissect the life style of bacterial pathogens and how to use this knowledge to optimize antimicrobial treatments.
Follow @banzhaflab.bsky.social for more updates
The Banzhaf group uses high-throughput methods to dissect the life style of bacterial pathogens and how to use this knowledge to optimize antimicrobial treatments.
Follow @banzhaflab.bsky.social for more updates
September 29, 2025 at 2:57 PM
Dr Manuel Banzhaf
The Banzhaf group uses high-throughput methods to dissect the life style of bacterial pathogens and how to use this knowledge to optimize antimicrobial treatments.
Follow @banzhaflab.bsky.social for more updates
The Banzhaf group uses high-throughput methods to dissect the life style of bacterial pathogens and how to use this knowledge to optimize antimicrobial treatments.
Follow @banzhaflab.bsky.social for more updates
Reposted by Caro Kobras 🐍
New online: Molecular basis for the activation of outer dynein arms in cilia
Molecular basis for the activation of outer dynein arms in cilia
Nature Structural & Molecular Biology, Published online: 29 September 2025; doi:10.1038/s41594-025-01680-9Issa et al. show that the ciliary small guanosine triphosphatase Arl3 displaces the inhibitory regulator Shulin/DNAAF9 from the outer dynein arm, leading to motor activation.
go.nature.com
September 29, 2025 at 3:15 PM
New online: Molecular basis for the activation of outer dynein arms in cilia
Reposted by Caro Kobras 🐍
New preprint out from the team! Master‘s student extraordinaire Julia Bauer stumbled across a Ca transporter needed for endospore maturation in Solibacillus 🧫🔬 www.biorxiv.org/content/10.1...
Decoding the functional role of the calcium ATPase YloB in microbially induced calcite precipitation and sporulation in Solibacillus silvestris
Calcium homeostasis is essential for bacterial physiology, yet its regulation and role in specialized processes such as microbially induced calcite precipitation (MICP) and sporulation remain poorly u...
www.biorxiv.org
September 26, 2025 at 6:45 AM
New preprint out from the team! Master‘s student extraordinaire Julia Bauer stumbled across a Ca transporter needed for endospore maturation in Solibacillus 🧫🔬 www.biorxiv.org/content/10.1...
Reposted by Caro Kobras 🐍
We're hiring (again)!
We are looking for an associate professor in cell and molecular biology, with a particular focus on immunology (defined broadly)
If you have a great record and exciting plans, consider joining our thriving and welcoming department
www.path.ox.ac.uk/vacancy/asso...
We are looking for an associate professor in cell and molecular biology, with a particular focus on immunology (defined broadly)
If you have a great record and exciting plans, consider joining our thriving and welcoming department
www.path.ox.ac.uk/vacancy/asso...
September 10, 2025 at 11:54 AM
We're hiring (again)!
We are looking for an associate professor in cell and molecular biology, with a particular focus on immunology (defined broadly)
If you have a great record and exciting plans, consider joining our thriving and welcoming department
www.path.ox.ac.uk/vacancy/asso...
We are looking for an associate professor in cell and molecular biology, with a particular focus on immunology (defined broadly)
If you have a great record and exciting plans, consider joining our thriving and welcoming department
www.path.ox.ac.uk/vacancy/asso...
Reposted by Caro Kobras 🐍
The Dunn School PhD programme is live! 🎉
Two projects in our labs:
1) How the motor protein giant dynein-2 works
2) How signalling-essential membrane proteins get into cilia
Cryo-EM/ET, single mol & live-cell fluor microscopy, CRISPR-based genetic tools & more!
www.path.ox.ac.uk/study-with-u...
Two projects in our labs:
1) How the motor protein giant dynein-2 works
2) How signalling-essential membrane proteins get into cilia
Cryo-EM/ET, single mol & live-cell fluor microscopy, CRISPR-based genetic tools & more!
www.path.ox.ac.uk/study-with-u...
How to Apply - Dunn School
Here you can find more information on how to apply for our PhD programme, including deadlines and application requirements.
www.path.ox.ac.uk
September 8, 2025 at 6:40 PM
The Dunn School PhD programme is live! 🎉
Two projects in our labs:
1) How the motor protein giant dynein-2 works
2) How signalling-essential membrane proteins get into cilia
Cryo-EM/ET, single mol & live-cell fluor microscopy, CRISPR-based genetic tools & more!
www.path.ox.ac.uk/study-with-u...
Two projects in our labs:
1) How the motor protein giant dynein-2 works
2) How signalling-essential membrane proteins get into cilia
Cryo-EM/ET, single mol & live-cell fluor microscopy, CRISPR-based genetic tools & more!
www.path.ox.ac.uk/study-with-u...
Reposted by Caro Kobras 🐍
A new methods paper from us, this time with a focus on reliable monitoring membrane potential and cell lysis at different growth stages and cell densities. Also, note the surprisingly high level of background lysis in seemingly healthy B. subtilis cultures.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Monitoring single cell bioenergetic status and cell lysis in dense and differentiating Bacillus subtilis cultures
Bacillus subtilis is a major model organism for studying population heterogeneity in clonal bacterial cultures due to its high genetic tractability and ability to differentiate into subpopulations wit...
www.biorxiv.org
August 22, 2025 at 7:24 AM
A new methods paper from us, this time with a focus on reliable monitoring membrane potential and cell lysis at different growth stages and cell densities. Also, note the surprisingly high level of background lysis in seemingly healthy B. subtilis cultures.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Caro Kobras 🐍
New preprint from us! The latest part of our C. difficile vancomycin resistance story. We identified a new two-component system (VnrRS) that can control expression of the vanG pathway - just needs one amino acid change
@buddlejess.bsky.social @brockhurstlab.bsky.social @claireyt.bsky.social
@buddlejess.bsky.social @brockhurstlab.bsky.social @claireyt.bsky.social
A novel two-component system controls vancomycin resistance in epidemic Clostridioides difficile
The glycopeptide antibiotic vancomycin is the frontline treatment for C. difficile infection in the UK. There have been only sporadic reports of resistance in the clinic but testing is rare so the tru...
www.biorxiv.org
August 22, 2025 at 9:39 AM
New preprint from us! The latest part of our C. difficile vancomycin resistance story. We identified a new two-component system (VnrRS) that can control expression of the vanG pathway - just needs one amino acid change
@buddlejess.bsky.social @brockhurstlab.bsky.social @claireyt.bsky.social
@buddlejess.bsky.social @brockhurstlab.bsky.social @claireyt.bsky.social
Reposted by Caro Kobras 🐍
🦠 A fan of bacteria?
We're hiring a Research Technician to join our team at the @warwicklifesci.bsky.social @uni-of-warwick.bsky.social
Positive, organised, skills in molecular biology and protein purification?
Apply here 👉 warwick-careers.tal.net/vx/appcentre...
Please share! 🔬
We're hiring a Research Technician to join our team at the @warwicklifesci.bsky.social @uni-of-warwick.bsky.social
Positive, organised, skills in molecular biology and protein purification?
Apply here 👉 warwick-careers.tal.net/vx/appcentre...
Please share! 🔬
August 15, 2025 at 8:26 AM
🦠 A fan of bacteria?
We're hiring a Research Technician to join our team at the @warwicklifesci.bsky.social @uni-of-warwick.bsky.social
Positive, organised, skills in molecular biology and protein purification?
Apply here 👉 warwick-careers.tal.net/vx/appcentre...
Please share! 🔬
We're hiring a Research Technician to join our team at the @warwicklifesci.bsky.social @uni-of-warwick.bsky.social
Positive, organised, skills in molecular biology and protein purification?
Apply here 👉 warwick-careers.tal.net/vx/appcentre...
Please share! 🔬
Reposted by Caro Kobras 🐍
Out yesterday. Using a translation reporter on a mini-tn5 transposon, and high freq. mutagenesis, we looked at translation on whole genome scale independently of genome annotation. academic.oup.com/nar/article/...
PIRT-Seq: a high-resolution whole-genome assay to identify protein-coding genes
Abstract. The advent of high-density mutagenesis and data-mining studies suggest the existence of further coding potential within bacterial genomes. Small
academic.oup.com
August 14, 2025 at 7:00 PM
Out yesterday. Using a translation reporter on a mini-tn5 transposon, and high freq. mutagenesis, we looked at translation on whole genome scale independently of genome annotation. academic.oup.com/nar/article/...
Reposted by Caro Kobras 🐍
Sinkende #Impfquoten verschärfen auch die Antibiotikaresistenz-Krise: Denn virale Infektionen wie #Masern können nicht selten zu bakteriellen Folgeerkrankungen führen - oft behandelt mit #Antibiotika. @ca.theconversation.com berichtet. #AMR theconversation.com/how-falling-...
How falling vaccination rates are fuelling the antibiotic resistance crisis
Measles is a viral infection, so antibiotics don’t treat it directly. But it weakens the immune system, leading to bacterial infections like pneumonia or ear infections, which do require antibiotics.
theconversation.com
July 29, 2025 at 8:03 AM
Sinkende #Impfquoten verschärfen auch die Antibiotikaresistenz-Krise: Denn virale Infektionen wie #Masern können nicht selten zu bakteriellen Folgeerkrankungen führen - oft behandelt mit #Antibiotika. @ca.theconversation.com berichtet. #AMR theconversation.com/how-falling-...
Reposted by Caro Kobras 🐍
Metal ions are universally required for life, and many of the foundational principles of metal homeostasis have emerged from studies of microbial systems. In this review, I provide a introductory overview targeted to those new to the field.
#MicroSky #Metals
rdcu.be/eycU2
#MicroSky #Metals
rdcu.be/eycU2
Microbial metal physiology: ions to ecosystems
Nature Reviews Microbiology - Metal ions are required for all cells, and their homeostasis relies on ancient mechanisms that facilitate their import, distribution and storage. In this Review,...
rdcu.be
July 28, 2025 at 5:08 PM
Metal ions are universally required for life, and many of the foundational principles of metal homeostasis have emerged from studies of microbial systems. In this review, I provide a introductory overview targeted to those new to the field.
#MicroSky #Metals
rdcu.be/eycU2
#MicroSky #Metals
rdcu.be/eycU2
Reposted by Caro Kobras 🐍
🚨New pre-print 🚨
We introduce our new tool GOLD-GWAS and demonstrate its use by digging into the evolution of MRSA facilitated by SCCmec
This work was led by talented PhD student @seungwonko.bsky.social who did most of the computational heavylifting 1/n
www.biorxiv.org/content/10.1...
We introduce our new tool GOLD-GWAS and demonstrate its use by digging into the evolution of MRSA facilitated by SCCmec
This work was led by talented PhD student @seungwonko.bsky.social who did most of the computational heavylifting 1/n
www.biorxiv.org/content/10.1...
Genome co-adaptation and the evolution of methicillin resistant Staphylococcus aureus (MRSA)
Background: Antimicrobial resistance (AMR) in bacterial pathogens is a major threat to global health, rendering standard treatments ineffective and increasing the risk of severe infection or death. Re...
www.biorxiv.org
July 23, 2025 at 10:50 AM
🚨New pre-print 🚨
We introduce our new tool GOLD-GWAS and demonstrate its use by digging into the evolution of MRSA facilitated by SCCmec
This work was led by talented PhD student @seungwonko.bsky.social who did most of the computational heavylifting 1/n
www.biorxiv.org/content/10.1...
We introduce our new tool GOLD-GWAS and demonstrate its use by digging into the evolution of MRSA facilitated by SCCmec
This work was led by talented PhD student @seungwonko.bsky.social who did most of the computational heavylifting 1/n
www.biorxiv.org/content/10.1...
Reposted by Caro Kobras 🐍
I'm very pleased to share the latest paper from my post doc with @kayla-king.bsky.social. We looked at how host microbiota can influence pathogen virulence evolution in a C. elegans model of infection: academic.oup.com/ismej/articl...
Within-host competition causes pathogen molecular evolution and perpetual microbiota dysbiosis
Abstract. Pathogens newly invading a host must compete with resident microbiota. This within-host microbial warfare could lead to more severe disease outco
academic.oup.com
June 18, 2025 at 2:29 PM
I'm very pleased to share the latest paper from my post doc with @kayla-king.bsky.social. We looked at how host microbiota can influence pathogen virulence evolution in a C. elegans model of infection: academic.oup.com/ismej/articl...
Thank you so much @melissawebby.bsky.social 😌 🥰 - biggest cheerleader and a super successful scientist herself!! 👩🔬
Just @carokobras.bsky.social doing amazing stuff! She is a fantastic scientist and wonderful person. If you don't already follow her you should because she has some really exciting science on the way!
May 7, 2025 at 8:30 PM
Thank you so much @melissawebby.bsky.social 😌 🥰 - biggest cheerleader and a super successful scientist herself!! 👩🔬
Reposted by Caro Kobras 🐍
Just @carokobras.bsky.social doing amazing stuff! She is a fantastic scientist and wonderful person. If you don't already follow her you should because she has some really exciting science on the way!
May 7, 2025 at 3:18 PM
Just @carokobras.bsky.social doing amazing stuff! She is a fantastic scientist and wonderful person. If you don't already follow her you should because she has some really exciting science on the way!
Congrats to all fellow fellows 🎉🥳 and thanks to @dunnschool.bsky.social for funding the work leading up to my proposal ☺️
Many congratulations to all our postdocs recently awarded postdoctoral fellowships! 🥳
A special mention to @carokobras.bsky.social for a BBSRC Fellowship, and Emma and Laura for @wellcometrust.bsky.social early career awards!
Check the full list here: www.path.ox.ac.uk/news-article...
Many congratulations to all our postdocs recently awarded postdoctoral fellowships! 🥳
A special mention to @carokobras.bsky.social for a BBSRC Fellowship, and Emma and Laura for @wellcometrust.bsky.social early career awards!
Check the full list here: www.path.ox.ac.uk/news-article...
April 18, 2025 at 6:10 AM
Congrats to all fellow fellows 🎉🥳 and thanks to @dunnschool.bsky.social for funding the work leading up to my proposal ☺️
Super excited to have been awarded a 2024 BBSRC Fellowship to investigate antibiotic tolerance in staphylococci! ☺️🧫🦠💊 @ukri.org
Very grateful for all the support I have received!!
www.ukri.org/news/9-milli...
Very grateful for all the support I have received!!
www.ukri.org/news/9-milli...
£9 million investment fuels groundbreaking bioscience research
From unlocking the secrets of animal movement to tackling antimicrobial resistance, UK’s brightest bioscience minds are pushing the boundaries of innovation.
www.ukri.org
April 17, 2025 at 3:13 PM
Super excited to have been awarded a 2024 BBSRC Fellowship to investigate antibiotic tolerance in staphylococci! ☺️🧫🦠💊 @ukri.org
Very grateful for all the support I have received!!
www.ukri.org/news/9-milli...
Very grateful for all the support I have received!!
www.ukri.org/news/9-milli...
Reposted by Caro Kobras 🐍
Reposted by Caro Kobras 🐍
💊🦠OUT NOW - comprehensive analysis of the propensity of ESKAPE pathogens to evolve resistance to new and in development antibiotics by Csaba Pal, Balint Kintses, Balazs Papp and colleagues. Dive in here...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro - Nature Microbiology
An extensive experimental analysis of resistance to antibiotics in development or introduced post-2017 in ESKAPE bacteria reveals the dynamics of resistance acquisition, mutational targets and the pre...
www.nature.com
January 13, 2025 at 1:57 PM
💊🦠OUT NOW - comprehensive analysis of the propensity of ESKAPE pathogens to evolve resistance to new and in development antibiotics by Csaba Pal, Balint Kintses, Balazs Papp and colleagues. Dive in here...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Caro Kobras 🐍
🚨 Our latest research in @naturecomms.bsky.social shows a promising strategy for less resistance-prone #antibiotics. For details, see the thread below and read the paper “Exploring the principles behind antibiotics with limited resistance” here: #MEvoSky www.nature.com/articles/s41...
Exploring the principles behind antibiotics with limited resistance - Nature Communications
This study shows that only those dual-targeting antibiotics limit resistance in Gram-negative pathogens that also target the membrane of the bacteria. This mechanism provides a basis for designing fut...
www.nature.com
February 24, 2025 at 11:09 AM
🚨 Our latest research in @naturecomms.bsky.social shows a promising strategy for less resistance-prone #antibiotics. For details, see the thread below and read the paper “Exploring the principles behind antibiotics with limited resistance” here: #MEvoSky www.nature.com/articles/s41...