Bharti Singal
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bhartisingal.bsky.social
Bharti Singal
@bhartisingal.bsky.social
Structural Biology, Biochemistry and Cell Biology, CryoEM, CryoET and FIB-SEM
Cryo-EM staff scientist @Stanford University 🇺🇸 | Former-PostDoc @UCDavis 🇺🇸 | Alumni of @NTUSingapore 🇸🇬and @UniversityofDelhi 🇮🇳| She/her
I was still thinking about the quantum computing stocks and now we already have drug discovery pipeline with quantum computing algorithms 🙄🙄
These days I feel impossible to catch up with the pace of structural biology and drug discovery www.nature.com/articles/s41... 👏👏
Quantum-computing-enhanced algorithm unveils potential KRAS inhibitors - Nature Biotechnology
A hybrid model combines quantum and classical approaches to generate compounds targeting the KRAS protein.
www.nature.com
January 23, 2025 at 6:07 AM
It was an amazing line up of speakers at the Cryo-EM: the next 50 years symposium. Meeting the pioneers in person and gaining insights for the future in CryoEM was the highlight of this meeting 👏
The Cryo-EM: the next 50 years Symposium held yesterday at @ucberkeleyofficial.bsky.social was a smashing success!!
January 12, 2025 at 8:30 PM
I think I can be rationally optimistic about 2025 😇🫶
This week so far is incredibly fruitful 🙏
This one thrown first time on grid and the protein complex is already screaming for data collection 🤞😎😇
P.S. - ignore the aggregates, we can deal with those later
#SPA #cryoem
January 10, 2025 at 7:21 AM
Reposted by Bharti Singal
Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍

Preprint📜: www.biorxiv.org/content/10.1...

A short thread🧵👇
January 6, 2025 at 11:19 AM
In my role at Stanford, I wear many hats 🕵️‍♂️, but the most fulfilling of all is training and making the cutting edge tech accessible. Seeing my trainees/collaborators push boundaries in science is truly fulfilling and their kind words make me feel genuinely appreciated! Remembering teaching days. ❄️🔬☃️
December 21, 2024 at 9:58 AM
Reposted by Bharti Singal
Online @cellpress.bsky.social, we reveal a protein shell that helps diatoms fix 20% of global #CO2 🧪🌊🌾🧶🧬🌍

Shimakawa et al:
www.cell.com/cell/fulltex...

Nam et al:
www.cell.com/cell/fulltex...

@biozentrum.bsky.social press release:
www.biozentrum.unibas.ch/news/detail/...

Read on for more...
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November 29, 2024 at 3:17 PM
Just so proud of seeing these skinny babies at the end of long tedious sessions #waffleMilling #teamtomo It was my personal goal to learn FIB-SEM this year. A super kind researcher trusted and collaborated and gave me a driving force 🙏 this is where I am in 4th session on this sample. More to go
December 18, 2024 at 3:09 AM
Reposted by Bharti Singal
Analysis of ribosomes from the Wild-type and FMR1 knockout human embryonic stem cells https://www.biorxiv.org/content/10.1101/2024.11.18.624098v1
Analysis of ribosomes from the Wild-type and FMR1 knockout human embryonic stem cells https://www.biorxiv.org/content/10.1101/2024.11.18.624098v1
Fragile X Messenger Ribonucleoprotein 1 (FMRP) is a multifunctional, multidomain RNA-binding protein
www.biorxiv.org
November 19, 2024 at 2:45 AM
Excited to share the collaboration project with Rohatgi lab at Stanford, recently published in Science www.science.org/doi/10.1126/...
Regulated N-glycosylation controls chaperone function and receptor trafficking
One-fifth of human proteins are N-glycosylated in the endoplasmic reticulum (ER) by two oligosaccharyltransferases, OST-A and OST-B. Contrary to the prevailing view of N-glycosylation as a housekeepin...
www.science.org
November 20, 2024 at 6:41 PM