Bernhard Zdársky
@bernhardzdarsky.bsky.social
Scientist | Molecular Biologist | Antifascist
#Cancer #Metastasis #Leukemia #AML #STAT3 @stoiberlab.bsky.social
#Cancer #Metastasis #Leukemia #AML #STAT3 @stoiberlab.bsky.social
Pinned
‼️Our latest study, “Loss of STAT3 in acute myeloid leukemia favors tissue infiltration linked to CXCR4 signaling,” is now out in @bloodneoplasia.bsky.social
#AML #STAT3 #CXCR4 #MLL-AF9
www.sciencedirect.com/science/arti...
#AML #STAT3 #CXCR4 #MLL-AF9
www.sciencedirect.com/science/arti...
Exciting new preprint out: “A STAT5B-driven mouse model of hepatosplenic γδ T-cell lymphoma reveals therapeutic efficacy of JAK inhibition”
#STAT5B #HSTCL #upadacitinib @biorxiv-cancer.bsky.social
www.biorxiv.org/content/10.1...
#STAT5B #HSTCL #upadacitinib @biorxiv-cancer.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 7, 2025 at 4:23 AM
Exciting new preprint out: “A STAT5B-driven mouse model of hepatosplenic γδ T-cell lymphoma reveals therapeutic efficacy of JAK inhibition”
#STAT5B #HSTCL #upadacitinib @biorxiv-cancer.bsky.social
www.biorxiv.org/content/10.1...
#STAT5B #HSTCL #upadacitinib @biorxiv-cancer.bsky.social
www.biorxiv.org/content/10.1...
Reposted by Bernhard Zdársky
🚨 Job alert! Interested in #metastasis, #TME, tumor-immune interactions and #heterogeneity? I am recruiting PhD candidates 🎓with computational expertise 👩💻 in single cell and spatial omics to join my lab in beautiful Vienna ✨. Applications until Nov 30 👉 tinyurl.com/ymantk2e
November 6, 2025 at 12:56 PM
🚨 Job alert! Interested in #metastasis, #TME, tumor-immune interactions and #heterogeneity? I am recruiting PhD candidates 🎓with computational expertise 👩💻 in single cell and spatial omics to join my lab in beautiful Vienna ✨. Applications until Nov 30 👉 tinyurl.com/ymantk2e
Reposted by Bernhard Zdársky
NAZI-LOKALE AUS DER DECKUNG HOLEN!
Am 6.11. soll in der Weinbar Vino in der Lichtenfelsgasse 3 im 1. Bezirk ein Nazi-Treffen der IB-Tarngruppe "Aktion 451" stattfinden. Dies wollen wir zum Anlass nehmen, das Lokal und dessen Betreiber Heinz Pollischansky näher zu beleuchten.
Am 6.11. soll in der Weinbar Vino in der Lichtenfelsgasse 3 im 1. Bezirk ein Nazi-Treffen der IB-Tarngruppe "Aktion 451" stattfinden. Dies wollen wir zum Anlass nehmen, das Lokal und dessen Betreiber Heinz Pollischansky näher zu beleuchten.
November 4, 2025 at 6:19 PM
NAZI-LOKALE AUS DER DECKUNG HOLEN!
Am 6.11. soll in der Weinbar Vino in der Lichtenfelsgasse 3 im 1. Bezirk ein Nazi-Treffen der IB-Tarngruppe "Aktion 451" stattfinden. Dies wollen wir zum Anlass nehmen, das Lokal und dessen Betreiber Heinz Pollischansky näher zu beleuchten.
Am 6.11. soll in der Weinbar Vino in der Lichtenfelsgasse 3 im 1. Bezirk ein Nazi-Treffen der IB-Tarngruppe "Aktion 451" stattfinden. Dies wollen wir zum Anlass nehmen, das Lokal und dessen Betreiber Heinz Pollischansky näher zu beleuchten.
Reposted by Bernhard Zdársky
Bücherfreund:innen aufgepasst! In Wien-Penzing entsteht das BuchQuartier, ein genossenschaftliches Buchcafé. Info-Veranstaltung am 23.9.2025. Mehr dazu hier:
#SDG3 #SDG4 #SDG11 #SDG17 #GLG
#SDG3 #SDG4 #SDG11 #SDG17 #GLG
Bücherwürmer gesucht!
Bücherfreund:innen aufgepasst! In Wien-Penzing entsteht das BuchQuartier, ein genossenschaftliches Buchcafé. Infoveranstaltung am 23.9.2025. Mehr dazu hier:
mutmacherei.net
September 19, 2025 at 6:03 AM
New research from D’Amico et al. shows that even when KRAS is removed from cancer cells, STAT3 continues to sustain tumorigenicity. This highlights STAT3 as a key vulnerability in KRAS-driven cancers
#KRAS #STAT3
www.embopress.org/doi/full/10....
#KRAS #STAT3
www.embopress.org/doi/full/10....
STAT3 sustains tumorigenicity following mutant KRAS ablation | EMBO reports
imageimageMechanisms underpinning resistance of tumorigenic cells to inactivation of oncogenic KRAS remain to be fully understood. This study shows that STAT3 sustains tumorigenicity of pancreatic cancer cells depleted of the mutant KRAS driver. ...
www.embopress.org
October 31, 2025 at 6:51 AM
New research from D’Amico et al. shows that even when KRAS is removed from cancer cells, STAT3 continues to sustain tumorigenicity. This highlights STAT3 as a key vulnerability in KRAS-driven cancers
#KRAS #STAT3
www.embopress.org/doi/full/10....
#KRAS #STAT3
www.embopress.org/doi/full/10....
Reposted by Bernhard Zdársky
Patient-specific enhancers in genetically uniform leukemias buff.ly/wU28vLW #hemesky
October 27, 2025 at 3:05 PM
Patient-specific enhancers in genetically uniform leukemias buff.ly/wU28vLW #hemesky
Reposted by Bernhard Zdársky
This aligns with findings from our lab where we show that AKT inhibition synergizes with MCL-1 inhibition to induce cell death in myeloma cells. ashpublications.org/bloodadvance...
AKT signaling restrains tumor suppressive functions of FOXO transcription factors and GSK3 kinase in multiple myeloma
Key Points. FOXO transcription factors and the GSK3 kinase are pivotal tumor suppressors restrained by AKT activity in MM cells.FOXO and GSK3 destabilize M
ashpublications.org
May 4, 2025 at 9:20 AM
This aligns with findings from our lab where we show that AKT inhibition synergizes with MCL-1 inhibition to induce cell death in myeloma cells. ashpublications.org/bloodadvance...
🔥Interestingly, loss of myeloid STAT3 attenuated steatosis but aggravated inflammation and fibrosis
www.mdpi.com/2073-4409/14...
#Liver #STAT3 #Fibrosis
www.mdpi.com/2073-4409/14...
#Liver #STAT3 #Fibrosis
www.mdpi.com
October 23, 2025 at 4:06 AM
🔥Interestingly, loss of myeloid STAT3 attenuated steatosis but aggravated inflammation and fibrosis
www.mdpi.com/2073-4409/14...
#Liver #STAT3 #Fibrosis
www.mdpi.com/2073-4409/14...
#Liver #STAT3 #Fibrosis
Reposted by Bernhard Zdársky
fanmade sticker🖤🌈
October 16, 2025 at 6:34 PM
fanmade sticker🖤🌈
‼️Our latest study, “Loss of STAT3 in acute myeloid leukemia favors tissue infiltration linked to CXCR4 signaling,” is now out in @bloodneoplasia.bsky.social
#AML #STAT3 #CXCR4 #MLL-AF9
www.sciencedirect.com/science/arti...
#AML #STAT3 #CXCR4 #MLL-AF9
www.sciencedirect.com/science/arti...
October 15, 2025 at 2:53 PM
‼️Our latest study, “Loss of STAT3 in acute myeloid leukemia favors tissue infiltration linked to CXCR4 signaling,” is now out in @bloodneoplasia.bsky.social
#AML #STAT3 #CXCR4 #MLL-AF9
www.sciencedirect.com/science/arti...
#AML #STAT3 #CXCR4 #MLL-AF9
www.sciencedirect.com/science/arti...
Reposted by Bernhard Zdársky
Nature research paper: Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22
go.nature.com/4gPjgfA
go.nature.com/4gPjgfA
Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22 - Nature
Dietary cysteine enhances intestinal stem cell-mediated intestinal repair following injury by promoting CD8 T cell-regenerative immune responses.
go.nature.com
October 7, 2025 at 2:21 PM
Nature research paper: Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22
go.nature.com/4gPjgfA
go.nature.com/4gPjgfA
Reposted by Bernhard Zdársky
Genomics fellows - ever wondered what to do with histopathology (e.g. H&E slides)? 🔬➕🧬🟰🤩 I am super excited to have contributed with @evachrenkova.bsky.social to this amazing effort of @andre-rendeiro.com & @yimin-zheng.bsky.social for multimodal data integration: LazySlide!🧵👇
🔬 Whole slide histopathology images are a goldmine for tissue biology and diagnostics - but too often locked away in inaccessible formats or tools. In our new preprint, we introduce LazySlide: an open-source, modular, and interoperable framework.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
June 2, 2025 at 9:02 AM
Genomics fellows - ever wondered what to do with histopathology (e.g. H&E slides)? 🔬➕🧬🟰🤩 I am super excited to have contributed with @evachrenkova.bsky.social to this amazing effort of @andre-rendeiro.com & @yimin-zheng.bsky.social for multimodal data integration: LazySlide!🧵👇
Reposted by Bernhard Zdársky
Nature research paper: STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity
https://go.nature.com/4dhenKu
https://go.nature.com/4dhenKu
STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity - Nature
Immune checkpoint blockade activates T cell immunity by reprogramming the STAT3 and STAT5 transcriptional pathways in dendritic cells, and STAT3 degradation is effective for treating tumours of multiple cancer types in mouse models.
go.nature.com
May 19, 2025 at 9:40 AM
Nature research paper: STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity
https://go.nature.com/4dhenKu
https://go.nature.com/4dhenKu