Arjun Aditham
@arjunine.bsky.social
new here. my handle is pronounced like arginine.
Our rabies glycoprotein is now online in Cell Host & Microbe (open access): www.cell.com/cell-host-mi...
In the revised manuscript, we added Figures S4 and S5, which contain further validation of candidate pre-fusion stabilization mutations for rabies G we highlighted in the preprint.
In the revised manuscript, we added Figures S4 and S5, which contain further validation of candidate pre-fusion stabilization mutations for rabies G we highlighted in the preprint.
Deep mutational scanning of rabies glycoprotein defines mutational constraint and antibody-escape mutations
Rabies virus causes thousands of human deaths annually and is the target of post-exposure
prophylactic development. Aditham et al. use a pseudovirus platform to measure how
all mutations to the rabies...
www.cell.com
May 20, 2025 at 9:30 PM
Our rabies glycoprotein is now online in Cell Host & Microbe (open access): www.cell.com/cell-host-mi...
In the revised manuscript, we added Figures S4 and S5, which contain further validation of candidate pre-fusion stabilization mutations for rabies G we highlighted in the preprint.
In the revised manuscript, we added Figures S4 and S5, which contain further validation of candidate pre-fusion stabilization mutations for rabies G we highlighted in the preprint.
Congratulations @pollyfordyce.bsky.social !! Super well-deserved :)
I am honored to be elected into the 2025 class of AAAS Fellows! It is surreal to see my name in the list.
I am very grateful to lab members over the last 10 years & to Aaron Streets & Jason Sello for the chance to co-launch the Next Gen Symposium (1/2).
news.stanford.edu/stories/2025...
I am very grateful to lab members over the last 10 years & to Aaron Streets & Jason Sello for the chance to co-launch the Next Gen Symposium (1/2).
news.stanford.edu/stories/2025...
Four Stanford faculty named AAAS Fellows
The faculty are among 471 new fellows of the American Association for the Advancement of Science.
news.stanford.edu
March 28, 2025 at 4:11 PM
Congratulations @pollyfordyce.bsky.social !! Super well-deserved :)
Thank you to @jbloomlab.bsky.social for the opportunity to work on/lead this study. We employ a pseudovirus system that is non-replicative and a safe way to study mutations to rabies G. Jesse already authored a very nice overarching summary, so I’ll zoom in on a couple points.
In new study, we measure how all mutations to rabies G affect cell entry & antibody neutralization
Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation
www.biorxiv.org/content/10.1...
Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation
www.biorxiv.org/content/10.1...
Deep mutational scanning of rabies glycoprotein defines mutational constraint and antibody-escape mutations
Rabies virus causes nearly 60,000 human deaths annually. Antibodies that target the rabies glycoprotein (G) are being developed as post-exposure prophylactics, but mutations in G can render such antib...
www.biorxiv.org
December 19, 2024 at 8:08 PM
Thank you to @jbloomlab.bsky.social for the opportunity to work on/lead this study. We employ a pseudovirus system that is non-replicative and a safe way to study mutations to rabies G. Jesse already authored a very nice overarching summary, so I’ll zoom in on a couple points.