Rosie Jackson
@aramblingrosie.bsky.social
Principal Investigator in #neuroscience at the University of Dundee. Trying to understand #Alzheimer’s Disease. In a love/hate relationship with #ApoE. I love hiking, cycling, cooking, and brains (but not at the same time)
🚀🧪🧠👩🔬⛰️🚴🏻♀️👩🍳
🚀🧪🧠👩🔬⛰️🚴🏻♀️👩🍳
Reposted by Rosie Jackson
Postdoctoral Researcher Vacancy in Structural or Chemical Biology at CeTPD, University of Dundee. Focus on molecular glue discovery in MND and FTD. Closing date: 6th October
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
Postdoc Research Assistant: Protein Degradation
Postdoctoral Researcher Vacancy in Structural or Chemical Biology at CeTPD, University of Dundee. Focus on molecular glue discovery in MND and FTD.
www.dementiaresearcher.nihr.ac.uk
September 9, 2025 at 9:10 AM
Postdoctoral Researcher Vacancy in Structural or Chemical Biology at CeTPD, University of Dundee. Focus on molecular glue discovery in MND and FTD. Closing date: 6th October
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
Reposted by Rosie Jackson
Postdoc Research Assistant in Dr Arpan Mehta’s lab at University of Dundee, using CRISPR screens in iPSC-derived motor neurons to study ALS mechanisms. Closing date: 4th August
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
Postdoc Research Assistant: Investigating C9ORF72
Postdoc Research Assistant in Dr Arpan Mehta’s lab at University of Dundee, using CRISPR screens in iPSC-derived motor neurons to study ALS mechanisms.
www.dementiaresearcher.nihr.ac.uk
July 23, 2025 at 8:38 AM
Postdoc Research Assistant in Dr Arpan Mehta’s lab at University of Dundee, using CRISPR screens in iPSC-derived motor neurons to study ALS mechanisms. Closing date: 4th August
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
A nice productive morning for me then…
July 22, 2025 at 8:09 AM
A nice productive morning for me then…
Reposted by Rosie Jackson
Join Dr Arpan Mehta's lab at MRC PPU, Dundee, for a 12-month postdoc using CRISPR screens to explore ALS in iPSC-derived motor neurons. Closing date: 18th July
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
Postdoc Research Assistant: Mechanisms of the C9ORF72
Join Dr Arpan Mehta's lab at MRC PPU, University of Dundee, for a 12-month postdoc using CRISPR screens to explore ALS in iPSC-derived motor neurons.
www.dementiaresearcher.nihr.ac.uk
June 21, 2025 at 8:22 PM
Join Dr Arpan Mehta's lab at MRC PPU, Dundee, for a 12-month postdoc using CRISPR screens to explore ALS in iPSC-derived motor neurons. Closing date: 18th July
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
Reposted by Rosie Jackson
So excited to see our work finally out today in Nature Communications! Brilliant summary by co-first author @sorayam.bsky.social below!
Our paper in Nature Comms is now online! Summary below but in short we use living human brain slice cultures in a number of different ways to model dementia processes. Big team effort led by myself, @robertmcgeachan.bsky.social and @clairedurrant1.bsky.social rdcu.be/ej647
Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures
Nature Communications - Understanding synapse loss in Alzheimer’s disease has been hampered by a lack of human model systems. Here, the authors show that manipulation of physiological or...
rdcu.be
April 30, 2025 at 3:35 PM
So excited to see our work finally out today in Nature Communications! Brilliant summary by co-first author @sorayam.bsky.social below!
Reposted by Rosie Jackson
Fantastic to see this work from @clairedurrant1.bsky.social group out in print! Important results using living human brain tissue to study Alzheimer’s disease www.nature.com/articles/s41...
Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures - Nature Communications
Understanding synapse loss in Alzheimer’s disease has been hampered by a lack of human model systems. Here, the authors show that manipulation of physiological or pathological Aβ has differing effects...
www.nature.com
April 30, 2025 at 12:02 PM
Fantastic to see this work from @clairedurrant1.bsky.social group out in print! Important results using living human brain tissue to study Alzheimer’s disease www.nature.com/articles/s41...
Always good to head back to st Andrews to chat with undergrads about neuroscience!
April 24, 2025 at 9:09 PM
Always good to head back to st Andrews to chat with undergrads about neuroscience!
Reposted by Rosie Jackson
Dr David Koss @davidkoss.bsky.social at University of Dundee is seeking a Postdoctoral Research Assistant to work on novel nuclear alpha-synuclein (aSyn) pathology and elevated DNA damage in Dementia with Lewy bodies. Closing date: 29th April
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
Postdoc Research Assistant: DNA damage in LBD
Dr David Koss at University of Dundee is seeking a Postdoctoral Research Assistant to work on novel nuclear alpha-synuclein (aSyn) pathology and elevated DNA damage in Dementia with Lewy bodies
www.dementiaresearcher.nihr.ac.uk
April 7, 2025 at 8:39 AM
Dr David Koss @davidkoss.bsky.social at University of Dundee is seeking a Postdoctoral Research Assistant to work on novel nuclear alpha-synuclein (aSyn) pathology and elevated DNA damage in Dementia with Lewy bodies. Closing date: 29th April
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
We love ApoE!!
Had a blast at the AAIC #APOE conference. Two whole days full of great talks, fab posters and wonderful chat with 250 of my fellow ApoE aficionados!
Had a blast at the AAIC #APOE conference. Two whole days full of great talks, fab posters and wonderful chat with 250 of my fellow ApoE aficionados!
March 18, 2025 at 8:15 PM
We love ApoE!!
Had a blast at the AAIC #APOE conference. Two whole days full of great talks, fab posters and wonderful chat with 250 of my fellow ApoE aficionados!
Had a blast at the AAIC #APOE conference. Two whole days full of great talks, fab posters and wonderful chat with 250 of my fellow ApoE aficionados!
In Edinburgh and just over heard a lad say to his friend that if Scotland loses today he’s going to piss on all the daffodils he can find.
Stay classy Scotland.
#sports!
Stay classy Scotland.
#sports!
March 8, 2025 at 12:00 PM
In Edinburgh and just over heard a lad say to his friend that if Scotland loses today he’s going to piss on all the daffodils he can find.
Stay classy Scotland.
#sports!
Stay classy Scotland.
#sports!
Reposted by Rosie Jackson
I am excited to have been awarded a Wellcome Trust CDA fellowship to study whether menopause enhances AD risk by exacerbating vascular dysfunction. I will be starting my lab in Manchester in January 2026, and would love to connect with other researchers interested in sex differences and AD 🧠🩸 🔬.
March 7, 2025 at 12:53 PM
I am excited to have been awarded a Wellcome Trust CDA fellowship to study whether menopause enhances AD risk by exacerbating vascular dysfunction. I will be starting my lab in Manchester in January 2026, and would love to connect with other researchers interested in sex differences and AD 🧠🩸 🔬.
Reposted by Rosie Jackson
Dr @aramblingrosie.bsky.social at University of Dundee is seeking x2 #PhD Students to Investigate the effects of Rare ApoE variants on protein function & structure + the Impact of ApoE source and isoform on Neuroinflammation - Closing date: 31 March
www.dementiaresearcher.nihr.ac.uk/find/jobs/?f...
www.dementiaresearcher.nihr.ac.uk/find/jobs/?f...
Jobs in Dementia Research
Find all the latest jobs in dementia research, in the UK and across the world. Working in all areas of discovery from fundamental science, clinical research, care and social sciences.
www.dementiaresearcher.nihr.ac.uk
March 6, 2025 at 9:40 PM
Dr @aramblingrosie.bsky.social at University of Dundee is seeking x2 #PhD Students to Investigate the effects of Rare ApoE variants on protein function & structure + the Impact of ApoE source and isoform on Neuroinflammation - Closing date: 31 March
www.dementiaresearcher.nihr.ac.uk/find/jobs/?f...
www.dementiaresearcher.nihr.ac.uk/find/jobs/?f...
Now is the moment!! If you'd like to come and do a PhD with me in sunny Dundee then I have not 1 but 2 funded PhD positions in my lab looking at #ApoE.
Please reach out with any questions!
Come do science with us, it'll be fun!
www.dundee.ac.uk/phds/opportu...
www.dundee.ac.uk/phds/opportu...
Please reach out with any questions!
Come do science with us, it'll be fun!
www.dundee.ac.uk/phds/opportu...
www.dundee.ac.uk/phds/opportu...
Investigating the impact of ApoE source and isoform on Neuroinflammation | University of Dundee, UK
A PhD project at the University of Dundee
www.dundee.ac.uk
March 5, 2025 at 5:24 PM
Now is the moment!! If you'd like to come and do a PhD with me in sunny Dundee then I have not 1 but 2 funded PhD positions in my lab looking at #ApoE.
Please reach out with any questions!
Come do science with us, it'll be fun!
www.dundee.ac.uk/phds/opportu...
www.dundee.ac.uk/phds/opportu...
Please reach out with any questions!
Come do science with us, it'll be fun!
www.dundee.ac.uk/phds/opportu...
www.dundee.ac.uk/phds/opportu...
Come and talk about mental health with us Wednesday at noon GMT!
Your mental health is so so important and we all have one; it may be great, it may need nurtured, but the more we talk about it the more we understand it.
I can't promise you any answers but hopefully you'll learn you're not alone!
Your mental health is so so important and we all have one; it may be great, it may need nurtured, but the more we talk about it the more we understand it.
I can't promise you any answers but hopefully you'll learn you're not alone!
Research can be demanding, often taking a toll on mental well-being. This weeks webinar is dedicated to helping researchers navigate these pressures! Break the stigma! With @leahfullegar.bsky.social @aramblingrosie.bsky.social
communities.dementiaresearcher.nihr.ac.uk/c/events/you...
communities.dementiaresearcher.nihr.ac.uk/c/events/you...
Salon - You're not alone... supporting good Mental Health
19th February, 12.00 pm GMT - Struggling with stress in academia? Join us to explore mental health support and resilience for researchers, students, and academics.
communities.dementiaresearcher.nihr.ac.uk
February 17, 2025 at 8:06 PM
Come and talk about mental health with us Wednesday at noon GMT!
Your mental health is so so important and we all have one; it may be great, it may need nurtured, but the more we talk about it the more we understand it.
I can't promise you any answers but hopefully you'll learn you're not alone!
Your mental health is so so important and we all have one; it may be great, it may need nurtured, but the more we talk about it the more we understand it.
I can't promise you any answers but hopefully you'll learn you're not alone!
Reposted by Rosie Jackson
The last of our new first time contributors is Athina Grigoriou, from the Koss Lab at University of Dundee. Working to identify a reciprocal relationship between DNA damage and neurodegeneration, specifically in synucleiopathies.
www.dementiaresearcher.nihr.ac.uk/profile-athi...
www.dementiaresearcher.nihr.ac.uk/profile-athi...
Profile – Athina Grigoriou, University of Dundee - DEMENTIA RESEARCHER
Athina Grigoriou, PhD Student at the University of Dundee working to identify a reciprocal relationship between DNA damage and neurodegeneration, specifically in synucleiopathies
www.dementiaresearcher.nihr.ac.uk
February 2, 2025 at 7:42 PM
The last of our new first time contributors is Athina Grigoriou, from the Koss Lab at University of Dundee. Working to identify a reciprocal relationship between DNA damage and neurodegeneration, specifically in synucleiopathies.
www.dementiaresearcher.nihr.ac.uk/profile-athi...
www.dementiaresearcher.nihr.ac.uk/profile-athi...
That feeling you get when you read a study that was similar (but crucially different) to yours and saw a similar result is such an amazing feeling.
January 30, 2025 at 4:34 PM
That feeling you get when you read a study that was similar (but crucially different) to yours and saw a similar result is such an amazing feeling.
Absolutely crucial paper showing that fixation time is important for RNAscope!
We also saw this when setting up our work and I only wish a paper like this had existed at the time so we knew where and how to focus our efforts!!!
We also saw this when setting up our work and I only wish a paper like this had existed at the time so we knew where and how to focus our efforts!!!
The first paper of the Jäkel lab is out!
We have shown that the RNA detection in human FFPE brain tissue significantly changes with fixation time. Chose your tissue well before doing an experiment!
doi.org/10.1093/brai...
We have shown that the RNA detection in human FFPE brain tissue significantly changes with fixation time. Chose your tissue well before doing an experiment!
doi.org/10.1093/brai...
Impact of fixation duration on messenger RNA detectability in human formalin-fixed paraffin embedded brain tissue
Hurler et al. performed RNAScope on post-mortem human brain tissue and found mRNA signal detection to be highly dependent on fixation time. Considering the
doi.org
November 29, 2024 at 9:42 AM
Absolutely crucial paper showing that fixation time is important for RNAscope!
We also saw this when setting up our work and I only wish a paper like this had existed at the time so we knew where and how to focus our efforts!!!
We also saw this when setting up our work and I only wish a paper like this had existed at the time so we knew where and how to focus our efforts!!!
Reposted by Rosie Jackson
If you missed this weeks webinar with tips on 'peer reviewing your first paper' you can watch the recording here:
communities.dementiaresearcher.nihr.ac.uk/c/events/pee...
communities.dementiaresearcher.nihr.ac.uk/c/events/pee...
Dementia Researcher Salon - Peer Reviewing your First Paper
Dementia Researcher Salon - Peer Reviewing your First Paper
communities.dementiaresearcher.nihr.ac.uk
November 28, 2024 at 7:51 AM
If you missed this weeks webinar with tips on 'peer reviewing your first paper' you can watch the recording here:
communities.dementiaresearcher.nihr.ac.uk/c/events/pee...
communities.dementiaresearcher.nihr.ac.uk/c/events/pee...
JOin us now to hear about how to review your first paper
communities.dementiaresearcher.nihr.ac.uk/live/peer-re...
communities.dementiaresearcher.nihr.ac.uk/live/peer-re...
Dementia Researcher Communities
Login to Dementia Researcher Communities community via email or SSO today.
communities.dementiaresearcher.nihr.ac.uk
November 27, 2024 at 12:10 PM
JOin us now to hear about how to review your first paper
communities.dementiaresearcher.nihr.ac.uk/live/peer-re...
communities.dementiaresearcher.nihr.ac.uk/live/peer-re...
Reposted by Rosie Jackson
The BNA scholars programme is now open for applications - this is a great scheme, instigated by @landreae.bsky.social (I can't tag the BNA as they aren't here yet I don't think)
www.bna.org.uk/mediacentre/...
www.bna.org.uk/mediacentre/...
Applications welcome for 2025 entry to the BNA Scholars Programme | Media | The British Neuroscience Association
www.bna.org.uk
November 21, 2024 at 9:17 AM
The BNA scholars programme is now open for applications - this is a great scheme, instigated by @landreae.bsky.social (I can't tag the BNA as they aren't here yet I don't think)
www.bna.org.uk/mediacentre/...
www.bna.org.uk/mediacentre/...
Reposted by Rosie Jackson
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
November 15, 2024 at 5:55 PM
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
One week left to apply for this job!!
I'm looking for a research tech to come and work on Alzheimers and ApoE! If you love cell culture, astrocytes, APOE or just fun science with fun people then come do science with us in beautiful Dundee!
tinyurl.com/a33kjn49
Seriously the sunsets are on point!
I'm looking for a research tech to come and work on Alzheimers and ApoE! If you love cell culture, astrocytes, APOE or just fun science with fun people then come do science with us in beautiful Dundee!
tinyurl.com/a33kjn49
Seriously the sunsets are on point!
November 20, 2024 at 8:30 AM
One week left to apply for this job!!
I'm looking for a research tech to come and work on Alzheimers and ApoE! If you love cell culture, astrocytes, APOE or just fun science with fun people then come do science with us in beautiful Dundee!
tinyurl.com/a33kjn49
Seriously the sunsets are on point!
I'm looking for a research tech to come and work on Alzheimers and ApoE! If you love cell culture, astrocytes, APOE or just fun science with fun people then come do science with us in beautiful Dundee!
tinyurl.com/a33kjn49
Seriously the sunsets are on point!
About to give my first taught lecture! Wish me luck BlueSky!
November 18, 2024 at 12:27 PM
About to give my first taught lecture! Wish me luck BlueSky!