@ankitsabharwal.bsky.social
Reposted
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 6, 2025 at 2:49 PM
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
Reposted
And finally - if you'd like to have our recent paper on functionally dominant mutations in mtDNA explained in podcast form, please see youtu.be/TY1hxrJzq5Q?...
p.s. thank you @albertosanzmon1.bsky.social :)
p.s. thank you @albertosanzmon1.bsky.social :)
Mitochondrial Ribosome Mutations: A Hidden Driver in Cancer
YouTube video by The Sanz Science Experience
youtu.be
November 5, 2025 at 1:49 PM
And finally - if you'd like to have our recent paper on functionally dominant mutations in mtDNA explained in podcast form, please see youtu.be/TY1hxrJzq5Q?...
p.s. thank you @albertosanzmon1.bsky.social :)
p.s. thank you @albertosanzmon1.bsky.social :)
Reposted
Required reading for cell biologists to get a sense of basic statistical principles!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ten essential tips for robust statistics in cell biology - Nature Cell Biology
Statistical thinking is a core part of solid, trustworthy biology. However, many studies still include insufficient sample sizes, have poor experimental design or select an incorrect statistical metho...
www.nature.com
November 4, 2025 at 7:23 PM
Required reading for cell biologists to get a sense of basic statistical principles!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
Want an easy way to support your model organism databases? Cite them!
Depending on the #zebrafish data you retrieve from ZFIN, you can show your support by using one of the formats below 🙏 🧪 #ZebrafishFunFacts
Depending on the #zebrafish data you retrieve from ZFIN, you can show your support by using one of the formats below 🙏 🧪 #ZebrafishFunFacts
![Citing ZFIN. We recommend the following formats for citing ZFIN in publications. For a general reference to the database, cite Bradford et al. 2022. For citing a specific entry in ZFIN: [Type of] data for this paper were retrieved from ZFIN, University of Oregon, Eugene, OR 97404-5274; URL: http://zfin.org/; [the date you retrieved the data cited].](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:lmndrquzjoynsxgz7rcn5unj/bafkreicstoaakfnbcpp5pgpqjpzwdcaclgr6diy7clnhmmsw32v4mnrare@jpeg)
October 22, 2025 at 4:32 PM
Want an easy way to support your model organism databases? Cite them!
Depending on the #zebrafish data you retrieve from ZFIN, you can show your support by using one of the formats below 🙏 🧪 #ZebrafishFunFacts
Depending on the #zebrafish data you retrieve from ZFIN, you can show your support by using one of the formats below 🙏 🧪 #ZebrafishFunFacts
Reposted
CRISPR technologies have transformed genetic research since their adaptation for genome editing in 2012. @burgesslab.bsky.social and I summarize key functional genomics tools being used in vertebrate models. www.nature.com/articles/s12...
CRISPR-based functional genomics tools in vertebrate models - Experimental & Molecular Medicine
Recent advances in DNA sequencing have allowed scientists to gather vast amounts of genetic data, but understanding what those sequences actually do requires additional tools that allow scientists to ...
www.nature.com
July 31, 2025 at 11:05 AM
CRISPR technologies have transformed genetic research since their adaptation for genome editing in 2012. @burgesslab.bsky.social and I summarize key functional genomics tools being used in vertebrate models. www.nature.com/articles/s12...
Reposted
Yes, it is crazy that all these papers came out at around the same time! McKenna Feltes in my lab together with my JHU colleagues Alexey Zimin and Steven Salzberg developed this amazing platform called WheresWalker to make positional cloning much easier.
journals.plos.org/plosgenetics...
journals.plos.org/plosgenetics...
Phenotype to genotype: A new and rapid approach using whole-genome sequencing
Author summary Forward genetic mutagenesis screening is an unbiased approach for the identification of mutations linked to a phenotype of interest. While this approach can be a powerful tool for uncov...
journals.plos.org
July 15, 2025 at 8:25 PM
Yes, it is crazy that all these papers came out at around the same time! McKenna Feltes in my lab together with my JHU colleagues Alexey Zimin and Steven Salzberg developed this amazing platform called WheresWalker to make positional cloning much easier.
journals.plos.org/plosgenetics...
journals.plos.org/plosgenetics...
Reposted
#IZFC2025 #zebrafish #DANIO-CODE data coordination centre is back online. Note changed address: danio-code-dcc.genereg.net
DANIO-CODE DCC
This Data Coordination Center allows DANIO-CODE consortium members to submit and view their data sets annotated with standard metadata nomenclatures.
danio-code-dcc.genereg.net
July 13, 2025 at 12:23 PM
#IZFC2025 #zebrafish #DANIO-CODE data coordination centre is back online. Note changed address: danio-code-dcc.genereg.net
Reposted
Creb3l3 loss = lipid overload in the gut 🥴
We show that Creb3l3 deficiency leads to intestinal lipid accumulation + altered ApoB lipoprotein metabolism.
Big implications for lipid disorders + metabolic disease!
🔗 www.jlr.org/article/S002...
#lipidmetabolism #zebrafish #CREB3L3 #metabolism
We show that Creb3l3 deficiency leads to intestinal lipid accumulation + altered ApoB lipoprotein metabolism.
Big implications for lipid disorders + metabolic disease!
🔗 www.jlr.org/article/S002...
#lipidmetabolism #zebrafish #CREB3L3 #metabolism
Creb3l3 deficiency promotes intestinal lipid accumulation and alters ApoB-containing lipoprotein kinetics
Elevated levels of triglycerides in the bloodstream, a condition known as hypertriglyceridemia,
represent a significant risk factor for the development of metabolic disorders and
cardiovascular diseas...
www.jlr.org
July 13, 2025 at 6:38 PM
Creb3l3 loss = lipid overload in the gut 🥴
We show that Creb3l3 deficiency leads to intestinal lipid accumulation + altered ApoB lipoprotein metabolism.
Big implications for lipid disorders + metabolic disease!
🔗 www.jlr.org/article/S002...
#lipidmetabolism #zebrafish #CREB3L3 #metabolism
We show that Creb3l3 deficiency leads to intestinal lipid accumulation + altered ApoB lipoprotein metabolism.
Big implications for lipid disorders + metabolic disease!
🔗 www.jlr.org/article/S002...
#lipidmetabolism #zebrafish #CREB3L3 #metabolism
Reposted
After a quarter of a century, the UCSC Genome Browser remains an essential tool for navigating the genome and understanding its structure, function and clinical impact
https://go.nature.com/40wPxkB
https://go.nature.com/40wPxkB
’We couldn’t live without it’: the UCSC Genome Browser turns 25
After a quarter of a century, the website remains an essential tool for navigating the genome and understanding its structure, function and clinical impact.
go.nature.com
June 30, 2025 at 11:49 AM
After a quarter of a century, the UCSC Genome Browser remains an essential tool for navigating the genome and understanding its structure, function and clinical impact
https://go.nature.com/40wPxkB
https://go.nature.com/40wPxkB
Reposted
I am so proud of calling Kev my colleague and my friend. He will always be the OG ZebrafishRock! and we are all very thankful for his service and his bottomless wisdom. Remember that ZebrafishRock will still be active on Slack and that you can sign up here: linktr.ee/zebrafishrock
June 26, 2025 at 5:30 AM
I am so proud of calling Kev my colleague and my friend. He will always be the OG ZebrafishRock! and we are all very thankful for his service and his bottomless wisdom. Remember that ZebrafishRock will still be active on Slack and that you can sign up here: linktr.ee/zebrafishrock
Reposted
For those interested! #ZebrafishMeeting
We are organizing a knock-in-focused workshop at Vilnius University Life Sciences Center. We would love to put together a session with graduate students and postdocs presenting! Preliminary program has links to registration and getting around. www.gmc.vu.lt/en/events-an...
Genome Editing in Zebrafish: Knock-ins and their applications
VU Gyvybės mokslų centras jungia tris VU padalinius – Biomokslų, Biotechnologijos ir Biochemijos institutus. Centras įkurtas vystant integruotą mokslo, studijų ir verslo centrą (slėnį) „Saulėtekis“.
www.gmc.vu.lt
June 25, 2025 at 4:52 PM
For those interested! #ZebrafishMeeting
Reposted
Re-upping x2
Query from Slack: Does anyone have good recommendations for antibodies that label mitochondrial DNA encoded proteins and work well in #zebrafish? #AskZebrafish
June 12, 2025 at 3:09 PM
Re-upping x2
Such a wonderful resource and review. Must read for the community!
Useful tips from @scekker.bsky.social et al. 🐟
A review emphasizes the advantages of using zebrafish in research, outlines key differences in experimental approaches, and offers guidelines for designing studies in a way that enhances experimental rigor and reproducibility. www.nature.com/articles/s42...
May 31, 2025 at 2:36 PM
Such a wonderful resource and review. Must read for the community!
Reposted
Some exciting news! NCBI has finished the annotation pipeline for our new #zebrafish reference sequence GRCz12tu:
www.ncbi.nlm.nih.gov/refseq/annot...
This is a big step up in data depth and quality and should be super helpful going forward.
www.ncbi.nlm.nih.gov/refseq/annot...
This is a big step up in data depth and quality and should be super helpful going forward.
Danio rerio Annotation ReportTwitterFacebookLinkedInGitHubNCBI Insights BlogTwitterFacebookYoutube
www.ncbi.nlm.nih.gov
May 15, 2025 at 4:23 PM
Some exciting news! NCBI has finished the annotation pipeline for our new #zebrafish reference sequence GRCz12tu:
www.ncbi.nlm.nih.gov/refseq/annot...
This is a big step up in data depth and quality and should be super helpful going forward.
www.ncbi.nlm.nih.gov/refseq/annot...
This is a big step up in data depth and quality and should be super helpful going forward.
Reposted
High-resolution optical imaging of the meninges within the brain of an adult zebrafish. Credit to @zebrafish007.bsky.social & #WeinsteinLab. #ZebrafishZunday 🧪
May 11, 2025 at 3:08 PM
High-resolution optical imaging of the meninges within the brain of an adult zebrafish. Credit to @zebrafish007.bsky.social & #WeinsteinLab. #ZebrafishZunday 🧪
Reposted
Simultaneous imaging of twelve #zebrafish embryos using Light Sheet Fluorescence Microscopy (LSFM). Credit to Prof. Jan Huisken & Flamingo Microscope (huiskenlab.com/flamingo/). #ZebrafishZunday 🧪
May 11, 2025 at 8:14 AM
Simultaneous imaging of twelve #zebrafish embryos using Light Sheet Fluorescence Microscopy (LSFM). Credit to Prof. Jan Huisken & Flamingo Microscope (huiskenlab.com/flamingo/). #ZebrafishZunday 🧪
Reposted
Welcome @burgesslab.bsky.social as an Associate Editor for #GENETICS 👋 Burgess, who will be joining the Experimental Technologies and Resources section, studies tissue regeneration in zebrafish and genome function. We’re delighted to have him on the team! Read more: buff.ly/k0yDk5c
April 30, 2025 at 4:03 PM
Welcome @burgesslab.bsky.social as an Associate Editor for #GENETICS 👋 Burgess, who will be joining the Experimental Technologies and Resources section, studies tissue regeneration in zebrafish and genome function. We’re delighted to have him on the team! Read more: buff.ly/k0yDk5c
Reposted
Handmade time-lapse of zebrafish-like development. Credit to Dr. Andro Montoya. #ZebrafishZunday 🧪
April 27, 2025 at 6:54 AM
Handmade time-lapse of zebrafish-like development. Credit to Dr. Andro Montoya. #ZebrafishZunday 🧪
Reposted
High impact, small size.
We welcome papers that address findings from a single set of experiments, or that are substantial enough to stand alone in 1,500 words or fewer.
Find out more 👇
We welcome papers that address findings from a single set of experiments, or that are substantial enough to stand alone in 1,500 words or fewer.
Find out more 👇
eLife Latest: Publish in a format that fits
Alongside Research Articles, eLife also publishes scientific discoveries in the form of Tools and Resources papers, Research Advances and Short Reports.
elifesciences.org
April 26, 2025 at 1:59 PM
High impact, small size.
We welcome papers that address findings from a single set of experiments, or that are substantial enough to stand alone in 1,500 words or fewer.
Find out more 👇
We welcome papers that address findings from a single set of experiments, or that are substantial enough to stand alone in 1,500 words or fewer.
Find out more 👇
Reposted
I'm thrilled to share that our story is now out in Science Advances! 🎉 We use quantitative imaging to map the mito central dogma, define translation hubs in the mitochondrial matrix, and show that they're replaced by Mitochondrial Stress Bodies (MSB) when mtRNA processing is perturbed 1/4
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress | Science Advances www.science.org/doi/10.1126/...
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress
Quantitative imaging of the mitochondrial central dogma identifies translation hubs that are suppressed during stress.
www.science.org
April 18, 2025 at 10:56 PM
I'm thrilled to share that our story is now out in Science Advances! 🎉 We use quantitative imaging to map the mito central dogma, define translation hubs in the mitochondrial matrix, and show that they're replaced by Mitochondrial Stress Bodies (MSB) when mtRNA processing is perturbed 1/4
Reposted
Zebrafish optic nerve injury results in systemic retinal ganglion cell dedifferentiation https://www.biorxiv.org/content/10.1101/2025.04.09.646875v1
April 16, 2025 at 11:33 AM
Reposted
Finally out! Brittney Voigt et al show the shared role of Inppl1a expansion of notochord vacuolated cells and also for hypertrophy of chondorcytes and bone lengthening. @currentbiology.bsky.social www.cell.com/current-biol...
Cell expansion for notochord mechanics and endochondral bone lengthening in zebrafish depends on the 5′-inositol phosphatase Inppl1a
Voigt et al. show that the 5′-inositol phosphatase gene inppl1a drives notochord expansion
independent of vacuole fusion. Defects in notochord expansion are exacerbated by locomotion,
causing more sev...
www.cell.com
April 9, 2025 at 3:49 PM
Finally out! Brittney Voigt et al show the shared role of Inppl1a expansion of notochord vacuolated cells and also for hypertrophy of chondorcytes and bone lengthening. @currentbiology.bsky.social www.cell.com/current-biol...
Reposted
“We report a novel imaging technique using a recently developed clearing reagent called LUCID that makes it possible to capture the complete cellular-resolution 3D structures of larval and juvenile zebrafish.”
New work from Weinstein Lab at NIH 🐟
New work from Weinstein Lab at NIH 🐟
April 8, 2025 at 6:21 PM
“We report a novel imaging technique using a recently developed clearing reagent called LUCID that makes it possible to capture the complete cellular-resolution 3D structures of larval and juvenile zebrafish.”
New work from Weinstein Lab at NIH 🐟
New work from Weinstein Lab at NIH 🐟
Reposted
GRCz12tu is available on Genbank. This will be one of two genomes that will be considered "reference" genomes, there will also be a GRCz12ab assembly coming. It has entered the NCBI annotation pipeline and will also go into the Ensembl annotation pipeline.
www.ncbi.nlm.nih.gov/datasets/gen...
www.ncbi.nlm.nih.gov/datasets/gen...
Danio rerio genome assembly GRCz12tu
- Danio rerio
www.ncbi.nlm.nih.gov
April 8, 2025 at 9:44 PM
GRCz12tu is available on Genbank. This will be one of two genomes that will be considered "reference" genomes, there will also be a GRCz12ab assembly coming. It has entered the NCBI annotation pipeline and will also go into the Ensembl annotation pipeline.
www.ncbi.nlm.nih.gov/datasets/gen...
www.ncbi.nlm.nih.gov/datasets/gen...
Reposted
#zebrafish Our Zebrafish Community Cre/lox Resource is online!! zebrafishccr.org
Check out what's available, imaging and information, and make a request.
We're so very grateful to the NIH ORIP for supporting this work!
Huge thanks to Parnal Joshi from Iddo Friedberg lab for creating the website!
Check out what's available, imaging and information, and make a request.
We're so very grateful to the NIH ORIP for supporting this work!
Huge thanks to Parnal Joshi from Iddo Friedberg lab for creating the website!
Zebrafish Community Cre/lox Resource - Zebrafish Community Cre/lox Resource
Bringing you precision Cre/CreERT2 and floxed lines driven by GeneWeld CRISPR targeted integration. Mission Our mission is to provide the Zebrafish community with Cre resources that open new areas of ...
zebrafishccr.org
April 1, 2025 at 5:52 PM
#zebrafish Our Zebrafish Community Cre/lox Resource is online!! zebrafishccr.org
Check out what's available, imaging and information, and make a request.
We're so very grateful to the NIH ORIP for supporting this work!
Huge thanks to Parnal Joshi from Iddo Friedberg lab for creating the website!
Check out what's available, imaging and information, and make a request.
We're so very grateful to the NIH ORIP for supporting this work!
Huge thanks to Parnal Joshi from Iddo Friedberg lab for creating the website!