Andrea Allegrini
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andrealle.bsky.social
Andrea Allegrini
@andrealle.bsky.social
480 followers 480 following 2 posts
Senior research fellow @ UCL
https://profiles.ucl.ac.uk/80153-andrea-allegrini
Posts Replies Media Videos
Reposted by Andrea Allegrini
bsiepe.bsky.social
We built the openESM database:
▶️60 openly available experience sampling datasets (16K+ participants, 740K+ obs.) in one place
▶️Harmonized (meta-)data, fully open-source software
▶️Filter & search all data, simply download via R/Python

Find out more:
🌐 openesmdata.org
📝 doi.org/10.31234/osf...
October 22, 2025 at 7:34 PM
Reposted by Andrea Allegrini
odedrechavi.bsky.social
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
Reposted by Andrea Allegrini
dingdingpeng.the100.ci
Gambetta & Origgi on the LL Game, in which agents prefer to deliver and receive (!) low quality.

This paper is absolutely savage but also feels uncomfortably relevant to parts of academia outside of Italy 👀

diegogambetta.org/wp-content/u...
Abstract We investigate a phenomenon which we have experienced as common when dealing with an assortment of Italian public and private institutions: people promise to exchange high-quality goods and services, but then something goes wrong and the quality delivered is lower than had been promised. While this is perceived as ‘cheating’ by outsiders, insiders seem not only to adapt to, but to rely on this outcome. They do not resent low-quality exchanges; in fact, they seem to resent high-quality ones, and are inclined to put pressure on or avoid dealing with agents who deliver high quality. The equilibrium among low-quality producers relies on an unusual preference ranking which differs from that associated with the Prisoners’ Dilemma and similar games, whereby self-interested rational agents prefer to dish out low quality in exchange for high quality. While equally ‘lazy’, agents in our low-quality worlds are oddly ‘pro-social’: for the advantage of maximizing their raw self-interest, they prefer to receive low-quality goods and services, provided that they too can in exchange deliver low quality without embarrassment. They develop a set of oblique social norms to sustain their preferred equilibrium when threatened by the intrusion of high quality. We argue that high-quality collective outcomes are endangered not only by self-interested individual defectors, but by ‘cartels’ of mutually satisfied mediocrities.
October 16, 2025 at 2:08 PM
Reposted by Andrea Allegrini
jessiebaldwin.bsky.social
I'm hiring! ✨ Looking for a Research Fellow to study environmental factors that mitigate intergenerational transmission of mental health.

3-year post at UCL @uclbrainscience.bsky.social with great opportunities for training, collaboration & exciting science!

🔗 Apply: www.jobs.ac.uk/job/DOZ633/r...
Research Fellow in Mental Health at UCL
Apply for the Research Fellow in Mental Health role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.
www.jobs.ac.uk
October 10, 2025 at 9:41 AM
Reposted by Andrea Allegrini
2damntrans.bsky.social
oh, this is good.
Philosophers described by Peep Show
YouTube video by JP
www.youtube.com
June 18, 2025 at 1:49 AM
Reposted by Andrea Allegrini
marghmalanchini.bsky.social
🧠🧬🧑‍🤝‍🧑 New CoDE Lab study: Disorder-specific genetic effects drive the associations between psychopathology and cognitive functioning. Link to preprint: www.medrxiv.org/content/10.1... Led by the brilliant Wangjingyi Liao 🌟

A short thread summarising the study👇
June 10, 2025 at 9:51 AM
Reposted by Andrea Allegrini
marghmalanchini.bsky.social
This work builds on our previous study, currently under review: www.medrxiv.org/content/10.1...

A special thank you to our wonderful co-authors! Engin Keser, @andrealle.bsky.social, @kailirimfeld.bsky.social, Robert Plomin
Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disorders
Evidence indicates a great degree of genetic overlap between psychiatric diagnoses. Accounting for these transdiagnostic effects can sharpen research on disorder-specific genetic architecture. Here we...
www.medrxiv.org
June 10, 2025 at 9:51 AM
Reposted by Andrea Allegrini
tabeasch.bsky.social
Happy to share our new study on genetic & environmental contributors to age-related decline in ~100K UK Biobank participants!

Here, we used simulation work + longitudinal GWAS and downstream analyses to explore risks involved in cognitive/physical decline
(1/)🧵🧵

shorturl.at/99gqL
Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline - Nature Communications
Large-scale genomic studies focusing on the genetic contribution to human aging have mostly relied on cross-sectional data. With the release of longitudinally curated aging phenotypes by the UK Bioban...
shorturl.at
May 19, 2025 at 12:29 PM
Reposted by Andrea Allegrini
sashagusevposts.bsky.social
I wrote about how population stratification in genetic analyses led to a decade of false findings and almost certainly continues to bias emerging results. But we are starting to have statistical tools to sniff it out. A 🧵:
How population stratification led to a decade of sensationally false genetic findings
Stratification makes environments look like genes
open.substack.com
March 28, 2025 at 9:54 PM
Reposted by Andrea Allegrini
dr-appie.bsky.social
In every civilization, people end up sorted into levels of socio-economic status (SES). We explore the history, present, and future of scientific research on the complicated relationship between SES and DNA in @naturehumbehav.bsky.social💰🧬🎓

Link: rdcu.be/efacK

Thread below 👇🏽
March 26, 2025 at 11:16 AM
andrealle.bsky.social
Our work on intergenerational transmission of psychiatric risk is now out!! www.nature.com/articles/s41... @naturecomms.bsky.social with thanks to my super coauthors @leofrach.bsky.social @jessiebaldwin.bsky.social and several others who made this possible
Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood - Nature Communications
Parental neuropsychiatric traits relate to children’s emotions and behaviours beyond genetic transmission alone. Here the author's findings suggest potential environmental risk factors that can act on...
www.nature.com
March 20, 2025 at 3:44 PM
Reposted by Andrea Allegrini
marghmalanchini.bsky.social
🧬🌳 New CoDE lab preprint: From genetic disposition to academic achievement: The mediating role of non-cognitive skills across development.

www.biorxiv.org/content/10.1...
On 🦋: @andrealle.bsky.social @kailirimfeld.bsky.social @laraffington.bsky.social

A short thread 👇 (1/9)
From genetic disposition to academic achievement: The mediating role of non-cognitive skills across development
Genetic effects on academic achievement are likely to capture environmental, developmental, and psychological processes. How these processes contribute to translating genetic dispositions into observe...
www.biorxiv.org
February 28, 2025 at 10:59 AM
Reposted by Andrea Allegrini
larseneault.bsky.social
🎆It's launch day! Check out our brand new @wellcometrust.bsky.social funded platform to explore over 1,600 datasets from across the world. Find the Atlas of longitudinal datasets here -> atlaslongitudinaldatasets.ac.uk
@kingsioppn.bsky.social @mqmentalhealth.bsky.social
#AtlasLongitudinalDatasets
Explore, filter, view, compare and save longitudinal datasets from across the world on the Atlas of Longitudinal Datasets!
January 22, 2025 at 9:32 AM
Reposted by Andrea Allegrini
tabeasch.bsky.social
Just out in @naturehumbehav.bsky.social !

We focused on the causes & impact of self-report error in the UK Biobank. We found that reporting error does not occur at random, is not independent of other participation behaviours, and can complicate the interpretation of GWA findings
shorturl.at/N4Qc6
The impact of self-report inaccuracy in the UK Biobank and its interplay with selective participation - Nature Human Behaviour
Biobank data are extensively used. Schoeler and colleagues show that self-report inaccuracy and selective participation are sources of poor reproducibility for biobank-scale research.
shorturl.at
December 19, 2024 at 8:09 AM
Reposted by Andrea Allegrini
leofrach.bsky.social
I guess I'm a doctor now??

Huge thanks to the best lab for all the memories over the last 4 years and for the sweetest messages 🥹

@giuliapiazza.bsky.social @emmarubyfrancis.bsky.social @andrealle.bsky.social @josejmorosoli.bsky.social @jessiebaldwin.bsky.social @kxlim.bsky.social
Viva celebrations Collage of photos with my PhD friends Dear Dr Frach, I am pleased to inform you that your examiners have confirmed that you have been successful in your recent examination for the Doctor of Philosophy degree.
December 18, 2024 at 10:47 AM
Reposted by Andrea Allegrini
gcbias.bsky.social
Just posting this to #popgen
Here's a link to my notes on population & quantitative genetics:
github.com/cooplab/popg...
Hoping to extend it more after the winter holidays, as I'm just finishing up teaching the undergrad version of class.
Releases · cooplab/popgen-notes
Population genetics notes. Contribute to cooplab/popgen-notes development by creating an account on GitHub.
github.com
November 19, 2024 at 11:37 PM
Reposted by Andrea Allegrini
psychgenomics.bsky.social
.
@jonicoleman.bsky.social & I are looking for a bioinformatics/genetics PhD student in this joint MRC industry PhD scheme "Unveiling Disease-Causing DNA Repeats with Long-Read Sequencing" - a 4 year PhD funded by Oxford Nanopore & The UK MRC.
www.findaphd.com/phds/project... #MRCDTP25
September 26, 2024 at 12:20 PM
Reposted by Andrea Allegrini
michelnivard.bsky.social

Overcomplete models, with more latent than observed variables, model complexity that traditional methods (PCA, SEM & ICA) can't uncover. A tutorial how to fit over-complete models in MCMSEM. MAny potential applications in epi, neuro, genetics & Psych🧠📊 Check it out: rpubs.com/MichelNivard...
September 25, 2024 at 1:15 PM
Reposted by Andrea Allegrini
michelnivard.bsky.social
I pushed an update for MCMSEM. MCMSEM is an advanced extension of SEM (Developed with Zenab Tamimy and Matthijs van der Zee), which considers not just covariance but also co-skewness and co-kurtosis. It means you can test causal models! github.com/MichelNivard... follow examples in the thread 👇 1/?
GitHub - MichelNivard/MCMSEM: Multi co-moment structural equation models
Multi co-moment structural equation models. Contribute to MichelNivard/MCMSEM development by creating an account on GitHub.
github.com
September 12, 2024 at 3:09 PM
Reposted by Andrea Allegrini
sashagusevposts.bsky.social
How you model phenotypes really matters: "When associations between items and PGSs were not adjusted for all associations between network nodes ... PGSs were associated with a broader set of items than those identified by network analysis."

jamanetwork.com/journals/jam...
Polygenic Scores and Networks of Psychopathology Symptoms
This cross-sectional study evaluates associations between polygenic scores with psychiatric disorder symptoms and relevant comorbid phenotypes.
jamanetwork.com
June 18, 2024 at 1:02 AM
Reposted by Andrea Allegrini
paturley.bsky.social
Here's a pretty good summary of the state of the field for how genetic data can be applied in economics research. On top of tying much of the field together in a consistent framework, there are also a handful of novel theoretical results. Excited to see this out!

t.co/d7g1SEEB6C
Social-Science Genomics: Progress, Challenges, and Future Directions
Founded in 1920, the NBER is a private, non-profit, non-partisan organization dedicated to conducting economic research and to disseminating research findings among academics, public policy makers, an...
t.co
May 9, 2024 at 5:59 PM
Reposted by Andrea Allegrini
michelnivard.bsky.social
I have been (foolishly?) searching for peak 2015-2017 twitter "science on socials" magic... In an experiment to recapture that excitement, I talked to @eikofried.bsky.social , in what might veer into podcast territory(?), about a new GWAS of Depression (N > 5 million) www.youtube.com/watch?v=vHvB...
is this an accidental Podcast? Eiko Fried & Michel Nivard discuss a new GWAS of depression preprint
I had a chat with Eiko Fried about a new GWAS of Depression in 685.000 cases and 4.3 million controls... That's like all of Denmark? Here is the GWAS: https:...
www.youtube.com
May 7, 2024 at 8:16 PM
Reposted by Andrea Allegrini
gcbias.bsky.social
Congratulations to Carl Veller on the publication of his article on confounding in population and family GWAS
journals.plos.org/plosbiology/...
Interpreting population- and family-based genome-wide association studies in the presence of confounding
GWASs aim to estimate direct effects of genotype on an individual’s phenotype, but this can be subject to genetic and environmental confounds and
journals.plos.org
April 12, 2024 at 4:28 AM
Reposted by Andrea Allegrini
michelnivard.bsky.social
I kicked off a series of posts on the "end of GWAS" . It'll be 5 posts, an intro and posts on GWAS of Height, depression, education and schizophrenia, each ample size > 500.000 individuals. I wrote these between jobs to think about whats next for my field & me nivard.substack.com/p/gwas-endga...
GWAS: endgame Vol. 1
What will the first of the last GWAS look like, whats after GWAS?
nivard.substack.com
April 4, 2024 at 4:27 PM
Reposted by Andrea Allegrini
leofrach.bsky.social
Our paper on genetic transmission and genetic nurture effects on conduct problems is now published in Molecular Psychiatry! This version includes new analyses www.nature.com/articles/s41... a 🧵 1/6
January 16, 2024 at 12:14 PM