Amsterdam Leukodystrophy Center
@amsterdamleuko.bsky.social
In the Amsterdam Leukodystrophy Center (ALC), clinicians and laboratory scientists work together to develop treatments for heritable white matter diseases | part of the Emma Children’s Hospital (Amsterdam UMC)
Steun onderzoek naar gentherapie voor Vanishing White Matter (VWM)!
Jouw steun brengt ons dichter bij een oplossing! Het onderzoek biedt nieuwe hoop voor patiënten en families.
Doneren en meer info via de link:
www.zzf.nl/zzf-onderzoe...
#VWM #ZeldzameZiekten #Gentherapie
Jouw steun brengt ons dichter bij een oplossing! Het onderzoek biedt nieuwe hoop voor patiënten en families.
Doneren en meer info via de link:
www.zzf.nl/zzf-onderzoe...
#VWM #ZeldzameZiekten #Gentherapie
Steun het onderzoek naar gentherapie voor vanishing white matter (VWM)
www.zzf.nl
October 31, 2025 at 12:55 PM
Steun onderzoek naar gentherapie voor Vanishing White Matter (VWM)!
Jouw steun brengt ons dichter bij een oplossing! Het onderzoek biedt nieuwe hoop voor patiënten en families.
Doneren en meer info via de link:
www.zzf.nl/zzf-onderzoe...
#VWM #ZeldzameZiekten #Gentherapie
Jouw steun brengt ons dichter bij een oplossing! Het onderzoek biedt nieuwe hoop voor patiënten en families.
Doneren en meer info via de link:
www.zzf.nl/zzf-onderzoe...
#VWM #ZeldzameZiekten #Gentherapie
- job alert -
Will you become our colleague at the Amsterdam Leukodystrophy Center? See the PhD opening below, focusing on the molecular basis of fluid regulation by astrocytes in the brain. Apply using the link below:
🔗 werkenbij.amsterdamumc.org/en/publicatie-1179368
Will you become our colleague at the Amsterdam Leukodystrophy Center? See the PhD opening below, focusing on the molecular basis of fluid regulation by astrocytes in the brain. Apply using the link below:
🔗 werkenbij.amsterdamumc.org/en/publicatie-1179368
June 11, 2025 at 2:40 PM
- job alert -
Will you become our colleague at the Amsterdam Leukodystrophy Center? See the PhD opening below, focusing on the molecular basis of fluid regulation by astrocytes in the brain. Apply using the link below:
🔗 werkenbij.amsterdamumc.org/en/publicatie-1179368
Will you become our colleague at the Amsterdam Leukodystrophy Center? See the PhD opening below, focusing on the molecular basis of fluid regulation by astrocytes in the brain. Apply using the link below:
🔗 werkenbij.amsterdamumc.org/en/publicatie-1179368
Reposted by Amsterdam Leukodystrophy Center
🚨 PhD position in astrocyte physiology!
Join us in Amsterdam to explore how astrocytes dynamically regulate brain water flow!
Apply using the link below:
🧠🔬🌍
🔗 werkenbij.amsterdamumc.org/en/publicatie-1179368
#Neuroscience #PhD #Astrocytes #MLC #SUPERGLUE
Join us in Amsterdam to explore how astrocytes dynamically regulate brain water flow!
Apply using the link below:
🧠🔬🌍
🔗 werkenbij.amsterdamumc.org/en/publicatie-1179368
#Neuroscience #PhD #Astrocytes #MLC #SUPERGLUE
Vacatures - PhD Cellular Neuroscience - Astrocyte Physiology - Amsterdam UMC
Amsterdam Leukodystrophy Center is looking for a motivated PhD candidate to explore the fundamental physiology of astrocytes in the brain, in the context of brain fluid regulation.
werkenbij.amsterdamumc.org
June 11, 2025 at 2:37 PM
🚨 PhD position in astrocyte physiology!
Join us in Amsterdam to explore how astrocytes dynamically regulate brain water flow!
Apply using the link below:
🧠🔬🌍
🔗 werkenbij.amsterdamumc.org/en/publicatie-1179368
#Neuroscience #PhD #Astrocytes #MLC #SUPERGLUE
Join us in Amsterdam to explore how astrocytes dynamically regulate brain water flow!
Apply using the link below:
🧠🔬🌍
🔗 werkenbij.amsterdamumc.org/en/publicatie-1179368
#Neuroscience #PhD #Astrocytes #MLC #SUPERGLUE
Reposted by Amsterdam Leukodystrophy Center
Fresh from the lab!
In this new paper, PhD student Sven Kerst shows how phenotypes observed in isolated cell models for the leukodystrophy MLC are also observed in intact astrocytes in acute brain slices!
Glia | Neurobiology Journal | Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
In this new paper, PhD student Sven Kerst shows how phenotypes observed in isolated cell models for the leukodystrophy MLC are also observed in intact astrocytes in acute brain slices!
Glia | Neurobiology Journal | Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
Impaired Volume Regulation and Electrophysiology of Astrocytes In Situ in a Mouse Model for Megalencephalic Leukoencephalopathy With Subcortical Cysts
Cell culture studies show disrupted astrocyte physiology in the leukodystrophy MLC. Are intact astrocytes similarly affected? This study on astrocytes in MLC mouse brain slices confirms and exten...
onlinelibrary.wiley.com
June 2, 2025 at 11:22 AM
Fresh from the lab!
In this new paper, PhD student Sven Kerst shows how phenotypes observed in isolated cell models for the leukodystrophy MLC are also observed in intact astrocytes in acute brain slices!
Glia | Neurobiology Journal | Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
In this new paper, PhD student Sven Kerst shows how phenotypes observed in isolated cell models for the leukodystrophy MLC are also observed in intact astrocytes in acute brain slices!
Glia | Neurobiology Journal | Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
Marjo van der Knaap has just opened the leukodystrophy symposium in Amsterdam, celebrating both 25 years of the ALC as well as Marjo’s farewell from clinical tasks.
We are very excited about the coming 2 days of white matter science!
We are very excited about the coming 2 days of white matter science!
May 22, 2025 at 6:41 AM
Marjo van der Knaap has just opened the leukodystrophy symposium in Amsterdam, celebrating both 25 years of the ALC as well as Marjo’s farewell from clinical tasks.
We are very excited about the coming 2 days of white matter science!
We are very excited about the coming 2 days of white matter science!
A new study from the ALC reveals how Eif2b5 mutations in different brain cell types (including oligodendrocytes and astrocytes) contribute to VWM.
Our findings challenge the idea that malfunction of a single cell type drives the disease.
Find the article at:
academic.oup.com/brain/advanc...
Our findings challenge the idea that malfunction of a single cell type drives the disease.
Find the article at:
academic.oup.com/brain/advanc...
Cell-specific Eif2b5 mutant mice: novel insights into roles of macroglia in vanishing white matter
Vanishing white matter (VWM) is a leukodystrophy caused by a genetic defect in translation initiation, with astrocytes thought to play a key role. Triñanes
academic.oup.com
May 12, 2025 at 8:24 AM
A new study from the ALC reveals how Eif2b5 mutations in different brain cell types (including oligodendrocytes and astrocytes) contribute to VWM.
Our findings challenge the idea that malfunction of a single cell type drives the disease.
Find the article at:
academic.oup.com/brain/advanc...
Our findings challenge the idea that malfunction of a single cell type drives the disease.
Find the article at:
academic.oup.com/brain/advanc...
⭐ New paper alert ⭐
Our recent work on anesthetics as potential stressor inducing acute decline in patients with vanishing white matter (VWM), is now published.
📖: www.sciencedirect.com/science/arti....
Our recent work on anesthetics as potential stressor inducing acute decline in patients with vanishing white matter (VWM), is now published.
📖: www.sciencedirect.com/science/arti....
Effect of Propofol and Sevoflurane on Vanishing White Matter Models
The leukodystrophy vanishing white matter (VWM) most often has its onset in childhood and is characterized by chronic decline and additionally stress-…
www.sciencedirect.com
April 14, 2025 at 9:52 AM
⭐ New paper alert ⭐
Our recent work on anesthetics as potential stressor inducing acute decline in patients with vanishing white matter (VWM), is now published.
📖: www.sciencedirect.com/science/arti....
Our recent work on anesthetics as potential stressor inducing acute decline in patients with vanishing white matter (VWM), is now published.
📖: www.sciencedirect.com/science/arti....
Reposted by Amsterdam Leukodystrophy Center
Excited to share our latest paper!
We argue that in MS, the primary immune attack isn’t on myelin or myelinated axons — but on the ion & water homeostasis machinery in astrocyte endfeet.
A short thread on this new perspective
1/11
We argue that in MS, the primary immune attack isn’t on myelin or myelinated axons — but on the ion & water homeostasis machinery in astrocyte endfeet.
A short thread on this new perspective
1/11
New online! Multiple sclerosis: an immune attack on astrocyte-mediated ion and water homeostasis
Multiple sclerosis: an immune attack on astrocyte-mediated ion and water homeostasis
Nature Reviews Neurology, Published online: 04 April 2025; doi:10.1038/s41582-025-01081-yAutoimmunity in multiple sclerosis (MS) is generally considered to be directed against components of myelin or oligodendrocytes. However, this Perspective argues that an immune attack on the ion and water homeostasis machinery in astrocytic endfeet is the primary event in MS and that myelin damage results from astrocyte dysfunction.
bit.ly
April 7, 2025 at 9:10 PM
Excited to share our latest paper!
We argue that in MS, the primary immune attack isn’t on myelin or myelinated axons — but on the ion & water homeostasis machinery in astrocyte endfeet.
A short thread on this new perspective
1/11
We argue that in MS, the primary immune attack isn’t on myelin or myelinated axons — but on the ion & water homeostasis machinery in astrocyte endfeet.
A short thread on this new perspective
1/11
Reposted by Amsterdam Leukodystrophy Center
My first post in the sky is a:
Job Alert!
We are looking for a PhD student to study astrocyte dysfunction in the rare neurological disease MLC. Looking for a challenge? See the job advertisement below!
werkenbij.amsterdamumc.org/en/vacatures...
Job Alert!
We are looking for a PhD student to study astrocyte dysfunction in the rare neurological disease MLC. Looking for a challenge? See the job advertisement below!
werkenbij.amsterdamumc.org/en/vacatures...
Vacatures - PhD Understanding and repairing astrocyte dysfunction in the leukodystrophy MLC - Amsterdam UMC
The Amsterdam Leukodystrophy Center is searching for a motivated PhD candidate, for a collaborative project on understanding astrocyte dysfunction in the leukodystrophy MLC.
werkenbij.amsterdamumc.org
November 19, 2024 at 7:56 PM
My first post in the sky is a:
Job Alert!
We are looking for a PhD student to study astrocyte dysfunction in the rare neurological disease MLC. Looking for a challenge? See the job advertisement below!
werkenbij.amsterdamumc.org/en/vacatures...
Job Alert!
We are looking for a PhD student to study astrocyte dysfunction in the rare neurological disease MLC. Looking for a challenge? See the job advertisement below!
werkenbij.amsterdamumc.org/en/vacatures...