Aino-Maija Leppä
amleppa.bsky.social
Aino-Maija Leppä
@amleppa.bsky.social
Current | Postdoc at Francis Crick Institute with Charles Swanton exploring lung cancer evolution.

Before | PhD at DKFZ with Andreas Trumpp charting AML heterogeneity.
Reposted by Aino-Maija Leppä
Researchers from the Crick, @dkfz.bsky.social and the German Red Cross Blood Donation Centre have found beneficial genetic changes that arise in the blood stem cells of people who regularly donate blood cells.

www.crick.ac.uk/news-and-fea...
Beneficial genetic changes observed in regular blood donors
Researchers at the Francis Crick Institute have identified genetic changes in blood stem cells from frequent blood donors that support the production of new, non-cancerous cells.
www.crick.ac.uk
March 11, 2025 at 3:37 PM
Reposted by Aino-Maija Leppä
Thrilled to share that our work from Trumpp Lab @hi-stem @dkfz.bsky.social is out in Nature.
We provide the first single-cell data on neurons infiltrating pancreatic tumors, offering new insights into cancer therapy. #cancerneuroscience @cn-hd.bsky.social
www.nature.com/articles/s41...
February 18, 2025 at 9:37 AM
Reposted by Aino-Maija Leppä
Today @nature.com on how pancreatic cancer can hijack our nervous system and how denervation may be therapeutic
www.nature.com/articles/s41...
Characterization of single neurons reprogrammed by pancreatic cancer - Nature
Nature - Characterization of single neurons reprogrammed by pancreatic cancer
www.nature.com
February 18, 2025 at 12:40 AM
Reposted by Aino-Maija Leppä
After 4y in the making, I am super excited that my main PhD project is published 🎉🥳🎉🎉🥳

www.nature.com/articles/s41...

LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space.

Some highlights⬇️
January 3, 2025 at 7:25 PM
Extremely proud to see my PhD project exploring intra-tumor heterogeneity in complex karyotype AML finally out in @NatureGenet! 🎉 👩🏻‍🔬

They say that 10,000 hours make you an expert, so I guess after more than five years of work I’m half-way there 😅 ⬇️1/5

www.nature.com/articles/s41...
Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype - Nature Genetics
An integrated single-cell multiomic analysis of complex karyotype acute myeloid leukemia characterizes intratumoral heterogeneity and highlights links to therapeutic sensitivities.
www.nature.com
November 25, 2024 at 4:31 PM