Alex Rampotas
@alexrampotas.bsky.social
Haematologist
Developing CAR-T for Myelofibrosis @uclcancer Roddie/Pule lab
#CART #MPN #translational_research 🇬🇷🇬🇧
Support by @BloodCancer_Res & @the_MRC
Developing CAR-T for Myelofibrosis @uclcancer Roddie/Pule lab
#CART #MPN #translational_research 🇬🇷🇬🇧
Support by @BloodCancer_Res & @the_MRC
Reposted by Alex Rampotas
Exciting times for mutCALR MPNs - lovely data from the ET cohort presented in late breaking abstract at @EHA_Hematology. Rapid platelet control after just 2 doses with 89% of patients benefitting from a molecular response with INCA033989. @mpnvoice.bsky.social @mpnrf.bsky.social @mpnhv.bsky.social
June 15, 2025 at 8:05 AM
Exciting times for mutCALR MPNs - lovely data from the ET cohort presented in late breaking abstract at @EHA_Hematology. Rapid platelet control after just 2 doses with 89% of patients benefitting from a molecular response with INCA033989. @mpnvoice.bsky.social @mpnrf.bsky.social @mpnhv.bsky.social
Check our commentary on the amazing work by Falgas et all on developing a TIM-3 armored CAR-T therapy
The failure of this mode of treatment is often ascribed to impaired patient T-cell “fitness” or the deleterious effect of the immunosuppressive B-ALL tumor microenvironment on CAR-T function in vivo. buff.ly/SVUZtgk #hemesky #immunobiologyandimmunotherapy
June 2, 2025 at 1:11 PM
Check our commentary on the amazing work by Falgas et all on developing a TIM-3 armored CAR-T therapy
🚨Very excited to see our work with Prof Claire Roddie out in @bloodjournal.bsky.social
CAR-T has revolutionized treatment for B-ALL, but what’s next? We discuss innovations, challenges, and the road ahead.
🔗 ashpublications.org/blood/articl...
#Leukemia #CARTcell #Hematology
CAR-T has revolutionized treatment for B-ALL, but what’s next? We discuss innovations, challenges, and the road ahead.
🔗 ashpublications.org/blood/articl...
#Leukemia #CARTcell #Hematology
April 4, 2025 at 6:15 AM
🚨Very excited to see our work with Prof Claire Roddie out in @bloodjournal.bsky.social
CAR-T has revolutionized treatment for B-ALL, but what’s next? We discuss innovations, challenges, and the road ahead.
🔗 ashpublications.org/blood/articl...
#Leukemia #CARTcell #Hematology
CAR-T has revolutionized treatment for B-ALL, but what’s next? We discuss innovations, challenges, and the road ahead.
🔗 ashpublications.org/blood/articl...
#Leukemia #CARTcell #Hematology
Reposted by Alex Rampotas
We are recruiting!! Ads now live for a Data Coordinator and 2 Research Assistants/biobankers to join a new @ludwigcancer.bsky.social - @imm.ox.ac.uk joint initiative to prevent progression from early- to advanced blood cancer. Joint posts with Adam Mead+others in Oxford Ludwig. Links below
March 27, 2025 at 7:59 AM
We are recruiting!! Ads now live for a Data Coordinator and 2 Research Assistants/biobankers to join a new @ludwigcancer.bsky.social - @imm.ox.ac.uk joint initiative to prevent progression from early- to advanced blood cancer. Joint posts with Adam Mead+others in Oxford Ludwig. Links below
Fantastic news and very well deserved award!!! It has been amazing working together
Super proud of brilliant NIH-OxCAM PhD student ZoeWong for winning the Doug Higgs Best Abstract award at Oxford Centre for Haematology Day @ox.ac.uk @ouhospitals.bsky.social @imm.ox.ac.uk, for her collab project with @alexrampotas.bsky.social. They are racking up prizes betw them…paper coming!
January 29, 2025 at 8:05 PM
Fantastic news and very well deserved award!!! It has been amazing working together
A very nice Sunday read on the challenged CAR-T cells face in tackling myeloid malignancies by Prof Beth Psaila and Zoe Wong
ashpublications.org/thehematolog...
ashpublications.org/thehematolog...
The Road Less Traveled: T Cell-Engaging Immunotherapies for Myeloid Malignancies
Bhagwat AS, Torres L, Shestova O, . Cytokine-mediated CAR T therapy resistance in AML. Nat Med. Published online September 27, 2024. PubMed
ashpublications.org
January 19, 2025 at 11:06 AM
A very nice Sunday read on the challenged CAR-T cells face in tackling myeloid malignancies by Prof Beth Psaila and Zoe Wong
ashpublications.org/thehematolog...
ashpublications.org/thehematolog...
Bye bye, bispecific?
Check out our commentary on the development of a CD19/BCMA dual targeting CAR-T for non-Hodgkin Lymphoma led by Bachiller et al.
Co-transduction for the win! Link below ⬇️ for free access authors.elsevier.com/a/1kIWB5QliS...
Check out our commentary on the development of a CD19/BCMA dual targeting CAR-T for non-Hodgkin Lymphoma led by Bachiller et al.
Co-transduction for the win! Link below ⬇️ for free access authors.elsevier.com/a/1kIWB5QliS...
December 21, 2024 at 10:35 AM
Bye bye, bispecific?
Check out our commentary on the development of a CD19/BCMA dual targeting CAR-T for non-Hodgkin Lymphoma led by Bachiller et al.
Co-transduction for the win! Link below ⬇️ for free access authors.elsevier.com/a/1kIWB5QliS...
Check out our commentary on the development of a CD19/BCMA dual targeting CAR-T for non-Hodgkin Lymphoma led by Bachiller et al.
Co-transduction for the win! Link below ⬇️ for free access authors.elsevier.com/a/1kIWB5QliS...
Many thanks for highlighting our work on CAR-T for Myelofibrosis! It has been a great meeting in San Diego #ASH24
ashpublications.org/ashnewsdaily...
ashpublications.org/ashnewsdaily...
Flash Forward: Blood Cancer Highlights and Insights From ASH 2024 | ASH News Daily | American Society of Hematology
ashpublications.org
December 19, 2024 at 3:34 PM
Many thanks for highlighting our work on CAR-T for Myelofibrosis! It has been a great meeting in San Diego #ASH24
ashpublications.org/ashnewsdaily...
ashpublications.org/ashnewsdaily...
Reposted by Alex Rampotas
As we’re coming towards the end of #ASH2024 I’d like to express my gratitude for the great science, company and feedback! @antoniorromera.bsky.social @alexrampotas.bsky.social @bethpsaila.bsky.social
December 10, 2024 at 3:01 PM
As we’re coming towards the end of #ASH2024 I’d like to express my gratitude for the great science, company and feedback! @antoniorromera.bsky.social @alexrampotas.bsky.social @bethpsaila.bsky.social
It was great pleasure. Amazing meeting with great MPN research presented
As we’re coming towards the end of #ASH2024 I’d like to express my gratitude for the great science, company and feedback! @antoniorromera.bsky.social @alexrampotas.bsky.social @bethpsaila.bsky.social
December 10, 2024 at 6:57 PM
It was great pleasure. Amazing meeting with great MPN research presented
Looking forward to presenting our result and discussing all about CAR-T cell therapy for mutated calreticulin myelofibrosis #ASH24 Do join!
December 9, 2024 at 1:17 PM
Looking forward to presenting our result and discussing all about CAR-T cell therapy for mutated calreticulin myelofibrosis #ASH24 Do join!
Thank you so much!!
December 9, 2024 at 6:37 AM
Thank you so much!!
Reposted by Alex Rampotas
You have been telling us why you chose #hematology and what inspires you each day. Your answers are becoming art!🎨 See it live in the Hall A lobby. #ASH24 #Hemesky
December 9, 2024 at 12:54 AM
You have been telling us why you chose #hematology and what inspires you each day. Your answers are becoming art!🎨 See it live in the Hall A lobby. #ASH24 #Hemesky
Very eloquent presentation by Antonio Romera from @bethpsaila.bsky.social lab on megakaryocyte biology and ability to take on DNA damage! Fantastic work #ASH24
December 8, 2024 at 5:58 PM
Very eloquent presentation by Antonio Romera from @bethpsaila.bsky.social lab on megakaryocyte biology and ability to take on DNA damage! Fantastic work #ASH24
Very honoured to receive the ASH-BSH abstract achievement award
The result of the tremendous work by so many talented people who I had the privilege to work with
Zoe Wong, Isaac Gannon, @bethpsaila.bsky.social, Claire Roddie, Martin Pule and many more
#ASH24
The result of the tremendous work by so many talented people who I had the privilege to work with
Zoe Wong, Isaac Gannon, @bethpsaila.bsky.social, Claire Roddie, Martin Pule and many more
#ASH24
December 8, 2024 at 6:45 AM
Very honoured to receive the ASH-BSH abstract achievement award
The result of the tremendous work by so many talented people who I had the privilege to work with
Zoe Wong, Isaac Gannon, @bethpsaila.bsky.social, Claire Roddie, Martin Pule and many more
#ASH24
The result of the tremendous work by so many talented people who I had the privilege to work with
Zoe Wong, Isaac Gannon, @bethpsaila.bsky.social, Claire Roddie, Martin Pule and many more
#ASH24
Very pleased to present the results of a UK wide collaborative study on real world efficacy and safety of Momelotininb
- >60% anaemia responses at 6 months
-G1-2 peripheral neuropathy (15%)
-unexpected thrombocytosis (?hepcidin dysregulation due to AVCR1 inhibition)
#ASH24 @bethpsaila.bsky.social
- >60% anaemia responses at 6 months
-G1-2 peripheral neuropathy (15%)
-unexpected thrombocytosis (?hepcidin dysregulation due to AVCR1 inhibition)
#ASH24 @bethpsaila.bsky.social
December 8, 2024 at 6:25 AM
Very pleased to present the results of a UK wide collaborative study on real world efficacy and safety of Momelotininb
- >60% anaemia responses at 6 months
-G1-2 peripheral neuropathy (15%)
-unexpected thrombocytosis (?hepcidin dysregulation due to AVCR1 inhibition)
#ASH24 @bethpsaila.bsky.social
- >60% anaemia responses at 6 months
-G1-2 peripheral neuropathy (15%)
-unexpected thrombocytosis (?hepcidin dysregulation due to AVCR1 inhibition)
#ASH24 @bethpsaila.bsky.social
Reposted by Alex Rampotas
Sunrise and moonset beyond the Coronado Bridge on a beautiful run around San Diego bay this morning
December 7, 2024 at 4:29 PM
Sunrise and moonset beyond the Coronado Bridge on a beautiful run around San Diego bay this morning
Reposted by Alex Rampotas
Really proud of our physio Steph! Thank you to UK Haemophilia Society, Ben and others for this lovely recognition of her care and support! @ouhospitals.bsky.social www.ouh.nhs.uk/news/article...
Award-winning physiotherapist celebrated for ‘outstanding’ care - Oxford University Hospitals
Award-winning physiotherapist celebrated for ‘outstanding’ care
www.ouh.nhs.uk
December 4, 2024 at 7:19 AM
Really proud of our physio Steph! Thank you to UK Haemophilia Society, Ben and others for this lovely recognition of her care and support! @ouhospitals.bsky.social www.ouh.nhs.uk/news/article...
Very nice review. As we have more options for myelofibrosis the choice of the right JAKi at the right time becomes ever more important
Check out our “In a Nutshell” review in Brit J Haem - When, Which and How to Switch - navigating JAK inhibitors for myelofibrosis onlinelibrary.wiley.com/doi/10.1111/...
When, which and how to switch: Navigating JAK inhibitors in myelofibrosis
Navigating choice of JAK inhibitor (JAKi) therapy for patients with myelofibrosis who are JAKi-naïve and for those who have previously been treated with a JAKi.
onlinelibrary.wiley.com
December 2, 2024 at 10:18 AM
Very nice review. As we have more options for myelofibrosis the choice of the right JAKi at the right time becomes ever more important
Reposted by Alex Rampotas
Do swing by to hear: (1) @antoniorromera.bsky.social present his fascinating work on how megakaryocytes tolerate whole genome duplication, implications for genome integrity & cancer evolution
November 29, 2024 at 10:52 PM
Do swing by to hear: (1) @antoniorromera.bsky.social present his fascinating work on how megakaryocytes tolerate whole genome duplication, implications for genome integrity & cancer evolution
Reposted by Alex Rampotas
and also not to be missed - Ros Cooper and Dan Royston's oral abstract 'mapping the human bone marrow in MPNs using Spatial Transcriptomics'
November 29, 2024 at 10:52 PM
and also not to be missed - Ros Cooper and Dan Royston's oral abstract 'mapping the human bone marrow in MPNs using Spatial Transcriptomics'
Reposted by Alex Rampotas
(3) Camelia Benlabiod presents her work from her PhD with Caroline Marty & Isabelle Plo @ Gustave Roussy on dissecting the cell-of-origin of mutCALR driven MPNs, and how del52 and ins5 elicit different signalling responses
November 29, 2024 at 10:52 PM
(3) Camelia Benlabiod presents her work from her PhD with Caroline Marty & Isabelle Plo @ Gustave Roussy on dissecting the cell-of-origin of mutCALR driven MPNs, and how del52 and ins5 elicit different signalling responses