Glia cells mediate cytokine signaling between the gut and the brain, linking sleep to inflammation in the gut.

Besides its beneficial effects against infection, trained immunity has recently been implicated in inflammation-related disorders and is being exploited in cancer immunotherapy. These advances may ena...

Particle exposure drives inflammation through unknown regulatory mechanisms. Cobo et al. identified a bifurcated transcriptional response in macrophages: an AMPK-TFEB/TFE3-DNMT3A/DOT1L axis controlling lysosomal acidification and a JNK-AP-1 pathway driving cytokine expression. These findings uncover distinct regulatory networks shaping inflammatory and lysosomal responses, offering insights into particle-associated diseases.

Metallophilic marginal zone macrophages are positioned strategically within the spleen to process internalized blood-borne materials. Mauvais et al. find that these CD169+ macrophages cross-prime CD8+ T cell responses to internalized antigens using a proteasome-independent pathway, contributing to antitumor immunity independently of type 1 conventional dendritic cells.

Individual researchers and university leaders need to make the case for science to their elected representatives and to the public at large.

Drugs like aspirin can enhance the anti-metastatic activity of T cells by blocking a platelet-mediated pathway of suppression.