AJ te Velthuis
@ajtevelthuis.bsky.social
Assistant Professor at Princeton University. RNA polymerases, RNA viruses, mutations, and innate immune responses. Funded by NIH, Wellcome, NSF. https://tevelthuislab.scholar.princeton.edu
Reposted by AJ te Velthuis
RNA structure modulates Cas13 activity and enables mismatch detection - @cambearon.bsky.social @princetonmolbio.bsky.social go.nature.com/4oglebG
RNA structure modulates Cas13 activity and enables mismatch detection - Nature Biotechnology
An effective CRISPR RNA occlusion strategy enhances mismatch detection when using Cas13.
go.nature.com
October 23, 2025 at 4:39 PM
RNA structure modulates Cas13 activity and enables mismatch detection - @cambearon.bsky.social @princetonmolbio.bsky.social go.nature.com/4oglebG
Reposted by AJ te Velthuis
There is still time to apply; join our team to work on influenza virus replication mechanisms!
Exciting job opportunities!
Two postdoc positions are available in the Fodor Lab at
@dunnschool.bsky.social to study influenza virus transcription, genome replication, nuclear export and assembly.
More info: my.corehr.com/pls/uoxrecru...
Two postdoc positions are available in the Fodor Lab at
@dunnschool.bsky.social to study influenza virus transcription, genome replication, nuclear export and assembly.
More info: my.corehr.com/pls/uoxrecru...
May 26, 2025 at 8:04 PM
There is still time to apply; join our team to work on influenza virus replication mechanisms!
Reposted by AJ te Velthuis
Excited to share our latest preprint in which we integrate mathematical modeling with experimental approaches to investigate how ⬆️ temperature influences aberrant RNA synthesis and innate immunity in flu infection 🦠
Flu infection => temperature⬆️ => NP levels⬇️ => aberrant RNAs⬆️ => interferon⬆️. Elegant modeling and experimental work by @karishmabisht.bsky.social and @danielweilandt.bsky.social! Preprint: www.biorxiv.org/content/10.1...
www.biorxiv.org
May 20, 2025 at 3:58 PM
Excited to share our latest preprint in which we integrate mathematical modeling with experimental approaches to investigate how ⬆️ temperature influences aberrant RNA synthesis and innate immunity in flu infection 🦠
Flu infection => temperature⬆️ => NP levels⬇️ => aberrant RNAs⬆️ => interferon⬆️. Elegant modeling and experimental work by @karishmabisht.bsky.social and @danielweilandt.bsky.social! Preprint: www.biorxiv.org/content/10.1...
www.biorxiv.org
May 20, 2025 at 2:49 AM
Flu infection => temperature⬆️ => NP levels⬇️ => aberrant RNAs⬆️ => interferon⬆️. Elegant modeling and experimental work by @karishmabisht.bsky.social and @danielweilandt.bsky.social! Preprint: www.biorxiv.org/content/10.1...
Reposted by AJ te Velthuis
3-year-old girl dies from H5N1 bird flu in Mexico’s first human case bnonews.com/index.php/20...
3-year-old girl dies from H5N1 bird flu in Mexico’s first human case
A three-year-old girl who became Mexico’s first confirmed human case of H5N1 avian influenza has died, the country’s Health Ministry announced. It marks Mexico’s first fatality linked to the bird flu ...
bnonews.com
April 8, 2025 at 9:23 PM
3-year-old girl dies from H5N1 bird flu in Mexico’s first human case bnonews.com/index.php/20...
Reposted by AJ te Velthuis
Yep, Pubmed here down as well
OK so pubmed is down for me... Can we freak out now?
March 1, 2025 at 6:58 PM
Yep, Pubmed here down as well
Reposted by AJ te Velthuis
It is worth paying close attention to the new bill "Dangerous Viral Gain of Function Research Moratorium Act" introduced by Senator Roger Marshall.
If enacted, it will effectively stop all of virological research, including for vaccines.
www.marshall.senate.gov/wp-content/u...
🧵👇
If enacted, it will effectively stop all of virological research, including for vaccines.
www.marshall.senate.gov/wp-content/u...
🧵👇
February 27, 2025 at 7:37 PM
It is worth paying close attention to the new bill "Dangerous Viral Gain of Function Research Moratorium Act" introduced by Senator Roger Marshall.
If enacted, it will effectively stop all of virological research, including for vaccines.
www.marshall.senate.gov/wp-content/u...
🧵👇
If enacted, it will effectively stop all of virological research, including for vaccines.
www.marshall.senate.gov/wp-content/u...
🧵👇
Reposted by AJ te Velthuis
We are at risk of abandoning “a deal where the government provides funding, and in exchange it gets products, research, national security, prestige, and the next generation of qualified scientists.” #academicsky
www.princeton.edu/news/2025/02...
www.princeton.edu/news/2025/02...
The partnership that drives America’s leadership in medical discovery: How it works and what’s at stake
With federal support, universities produce world-changing discoveries and the next generation of exquisitely well-trained researchers.
www.princeton.edu
March 1, 2025 at 11:04 AM
We are at risk of abandoning “a deal where the government provides funding, and in exchange it gets products, research, national security, prestige, and the next generation of qualified scientists.” #academicsky
www.princeton.edu/news/2025/02...
www.princeton.edu/news/2025/02...
Reposted by AJ te Velthuis
FWIW, it's perhaps worth noting that when Benjamin Franklin visited France between 1776 and 1778 to ask for military support for the then-new-formed United States of America, he wore a coonskin cap. "Proper" French court attire at this time was a powdered wig.
March 1, 2025 at 1:00 AM
FWIW, it's perhaps worth noting that when Benjamin Franklin visited France between 1776 and 1778 to ask for military support for the then-new-formed United States of America, he wore a coonskin cap. "Proper" French court attire at this time was a powdered wig.
Reposted by AJ te Velthuis
My new piece in @theguardian.com
Techno-optimism is human pessimism.
www.theguardian.com/commentisfre...
Techno-optimism is human pessimism.
www.theguardian.com/commentisfre...
AI is ‘beating’ humans at empathy and creativity. But these games are rigged | MJ Crockett
Research pitting people against AI systems gives AI an edge by asking us to perform in machine-like ways
www.theguardian.com
February 27, 2025 at 3:30 PM
My new piece in @theguardian.com
Techno-optimism is human pessimism.
www.theguardian.com/commentisfre...
Techno-optimism is human pessimism.
www.theguardian.com/commentisfre...
Reposted by AJ te Velthuis
Despite everything, I still really want to celebrate the wonderful folks in my group, so I hope it is ok if i write about our latest work.
I am very proud of all the authors, and our collaborators, on our work just published in Nature communications.
www.nature.com/articles/s41...
I am very proud of all the authors, and our collaborators, on our work just published in Nature communications.
www.nature.com/articles/s41...
Analysis of NS2-dependent effects on influenza PB1 segment extends replication requirements beyond the canonical promoter - Nature Communications
The eight genomics segments of Influenza A virus exhibit different replication dynamics during infection. Here, the authors show through a range of mutant libraries of HA and PB1 segments that Influen...
www.nature.com
February 26, 2025 at 6:03 PM
Despite everything, I still really want to celebrate the wonderful folks in my group, so I hope it is ok if i write about our latest work.
I am very proud of all the authors, and our collaborators, on our work just published in Nature communications.
www.nature.com/articles/s41...
I am very proud of all the authors, and our collaborators, on our work just published in Nature communications.
www.nature.com/articles/s41...
Reposted by AJ te Velthuis
Negative-Strand RNA Virus meeting #NSV2025 registration is now open!
Visit www.negativestrandvirus.org/home
Visit www.negativestrandvirus.org/home
February 17, 2025 at 10:21 AM
Negative-Strand RNA Virus meeting #NSV2025 registration is now open!
Visit www.negativestrandvirus.org/home
Visit www.negativestrandvirus.org/home
Excited to share this new preprint showing that non-canonical influenza virus transcripts are produced in a sequence/RNA structure-dependent manner on aberrant RNAs: www.biorxiv.org/content/10.1...
A two-step mechanism for RIG-I activation by influenza virus mini viral RNAs
Influenza A virus (IAV) non-canonical replication products can be bound by various host pathogen sensors, including retinoic acid-inducible gene I (RIG-I). However, it is not clear why non-canonical I...
www.biorxiv.org
January 5, 2025 at 5:58 PM
Excited to share this new preprint showing that non-canonical influenza virus transcripts are produced in a sequence/RNA structure-dependent manner on aberrant RNAs: www.biorxiv.org/content/10.1...
Reposted by AJ te Velthuis
A two-step mechanism for RIG-I activation by influenza virus mini viral RNAs https://www.biorxiv.org/content/10.1101/2025.01.04.630666v1
January 5, 2025 at 7:18 AM
A two-step mechanism for RIG-I activation by influenza virus mini viral RNAs https://www.biorxiv.org/content/10.1101/2025.01.04.630666v1
Reposted by AJ te Velthuis
They can all be downloaded from here: cvr-engagement.co.uk/virus-snowfl..., except for...
Virus Snowflakes — CVR Engagement
cvr-engagement.co.uk
December 18, 2024 at 3:53 PM
They can all be downloaded from here: cvr-engagement.co.uk/virus-snowfl..., except for...
Reposted by AJ te Velthuis
What we are waiting for to wake up?
"The patient had been in contact with sick and dead birds in backyard flocks, the Centers for Disease Control and Prevention said"
@adamjkucharski.bsky.social discusses effective outbreak response @plosbiology.org plos.io/3ZnpcnE
apnews.com/article/bird...
🧪
"The patient had been in contact with sick and dead birds in backyard flocks, the Centers for Disease Control and Prevention said"
@adamjkucharski.bsky.social discusses effective outbreak response @plosbiology.org plos.io/3ZnpcnE
apnews.com/article/bird...
🧪
Health officials say Louisiana patient is first severe bird flu case in US
A person in Louisiana has the first severe illness caused by bird flu in the U.S., health officials said Wednesday.
apnews.com
December 18, 2024 at 6:37 PM
What we are waiting for to wake up?
"The patient had been in contact with sick and dead birds in backyard flocks, the Centers for Disease Control and Prevention said"
@adamjkucharski.bsky.social discusses effective outbreak response @plosbiology.org plos.io/3ZnpcnE
apnews.com/article/bird...
🧪
"The patient had been in contact with sick and dead birds in backyard flocks, the Centers for Disease Control and Prevention said"
@adamjkucharski.bsky.social discusses effective outbreak response @plosbiology.org plos.io/3ZnpcnE
apnews.com/article/bird...
🧪
Reposted by AJ te Velthuis
We have another new preprint up!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Novel CRITR-seq approach reveals influenza transcription is modulated by NELF and is a key event precipitating an interferon response
Transcription of interferons upon viral infection is critical for cell-intrinsic innate immunity. This process is influenced by many host and viral factors. To identify host factors that modulate inte...
www.biorxiv.org
November 17, 2024 at 4:43 AM
We have another new preprint up!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by AJ te Velthuis
(this is very consistent with another work from @ajtevelthuis.bsky.social which we were happy to contribute to, found at www.biorxiv.org/content/10.1...)
Influenza A virus transcription generates capped cRNAs that activate RIG-I
During influenza A virus (IAV) infection, host pathogen receptor retinoic acid-inducible gene I (RIG-I) detects the partially complementary, 5’-triphosphorylated ends of the viral genome segments and ...
www.biorxiv.org
November 17, 2024 at 4:43 AM
(this is very consistent with another work from @ajtevelthuis.bsky.social which we were happy to contribute to, found at www.biorxiv.org/content/10.1...)
We have found a capped flu RNA that was hiding in plain sight. In our preprint we show how this RNA activates RIG-I through a non-canonical mechanism. Fantastic work by Liza Elshina and many thanks to collaborators @alistairrussell.bsky.social and Joe Marcotrigiano! biorxiv.org/content/10.1...
November 13, 2024 at 3:37 AM
We have found a capped flu RNA that was hiding in plain sight. In our preprint we show how this RNA activates RIG-I through a non-canonical mechanism. Fantastic work by Liza Elshina and many thanks to collaborators @alistairrussell.bsky.social and Joe Marcotrigiano! biorxiv.org/content/10.1...
Reposted by AJ te Velthuis
We have a new preprint up!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Efficient genome replication in influenza A virus requires NS2 and sequence beyond the canonical promoter
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
September 11, 2024 at 5:48 PM
We have a new preprint up!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Transient RNA structures contribute to highly pathogenic flu emergence! Fantastic work by Mathis Funk and Mathilde Richard now on BioRxiv: biorxiv.org/content/10.1... For supporting data see: science.org/doi/10.1126/...
Transient RNA structures underlie highly pathogenic avian influenza virus genesis
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
biorxiv.org
January 12, 2024 at 11:43 AM
Transient RNA structures contribute to highly pathogenic flu emergence! Fantastic work by Mathis Funk and Mathilde Richard now on BioRxiv: biorxiv.org/content/10.1... For supporting data see: science.org/doi/10.1126/...
Excited to share a preprint on quantifying aberrant viral RNAs using Cas13. We reveal surprisingly reproducible kinetics of individual influenza virus mvRNAs in infection and detect mvRNAs even in clinical samples! www.biorxiv.org/content/10.1...
November 4, 2023 at 11:05 AM
Excited to share a preprint on quantifying aberrant viral RNAs using Cas13. We reveal surprisingly reproducible kinetics of individual influenza virus mvRNAs in infection and detect mvRNAs even in clinical samples! www.biorxiv.org/content/10.1...
Reposted by AJ te Velthuis
The Scientific American mask article with @sameo416.bsky.social and @jvipondmd.bsky.social
www.scientificamerican.com/article/mask...
www.scientificamerican.com/article/mask...
Masks Work. Distorting Science to Dispute the Evidence Doesn’t
New mask studies relying on a medical paradigm do not erase decades of engineering and occupational science that show they work
www.scientificamerican.com
October 17, 2023 at 8:43 PM
The Scientific American mask article with @sameo416.bsky.social and @jvipondmd.bsky.social
www.scientificamerican.com/article/mask...
www.scientificamerican.com/article/mask...