Anais Elewaut
@aelewaut.bsky.social
Postdoc in the @Kaech lab at the Salk Institute. Previously PhD student @Obenauf lab at the IMP in Vienna. Interested in #immuno-oncology#gbm#neuroscience
Pinned
Anais Elewaut
@aelewaut.bsky.social
· Nov 27
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
Extremely excited to see my PhD work in the @obenaufa.bsky.social published today in @natureportfolio.bsky.social 🤩. A big thank you to everyone who contributed, special thank you to my partner in crime @guillemxtivill.bsky.social - it was a lot of fun to work on this together! 🥳
Reposted by Anais Elewaut
Interested in how T cells are regulated in a tissue-specific manner? Karthik Varanasi’s exciting work shows Bile Acid synthesis impedes tumor-specific T cell responses during liver cancer @science.org Huge THANKS to all the amazing collaborators + @salkinstitute, SBP
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Bile acid synthesis impedes tumor-specific T cell responses during liver cancer
The metabolic landscape of cancer greatly influences antitumor immunity, yet it remains unclear how organ-specific metabolites in the tumor microenvironment influence immunosurveillance. We found that...
www.science.org
January 11, 2025 at 10:12 PM
Interested in how T cells are regulated in a tissue-specific manner? Karthik Varanasi’s exciting work shows Bile Acid synthesis impedes tumor-specific T cell responses during liver cancer @science.org Huge THANKS to all the amazing collaborators + @salkinstitute, SBP
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Anais Elewaut
The new CRISPR-StAR tool by @ulielling.bsky.social and team provides elegant new opportunities for in vivo screens. Glad we @aelewaut.bsky.social could contribute a bit.
Today we published a new paradigm to do CRISPR screens in complex model systems such as in vivo but also e.g. in organoids. The publication came out in Nature Biotechnology.
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www.nature.com/articles/s41...
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www.nature.com/articles/s41...
CRISPR-StAR enables high-resolution genetic screening in complex in vivo models - Nature Biotechnology
Pooled genetic CRISPR screening is improved in complex models through leveraging internal controls.
www.nature.com
January 2, 2025 at 11:21 PM
The new CRISPR-StAR tool by @ulielling.bsky.social and team provides elegant new opportunities for in vivo screens. Glad we @aelewaut.bsky.social could contribute a bit.
Reposted by Anais Elewaut
Thrilled to share that our paper www.nature.com/articles/s41... is featured in a fantastic Nature News & Views piece by thomastueting.bsky.social! 🎉 Grateful for the spotlight on our research and its impact on understanding cancer immunology. www.nature.com/articles/d41... 👀👉 rdcu.be/d3cRz
A lipid made by tumour cells reprograms immune cells
Insights into how cancer cells become unresponsive to therapy.
www.nature.com
December 14, 2024 at 10:51 PM
Thrilled to share that our paper www.nature.com/articles/s41... is featured in a fantastic Nature News & Views piece by thomastueting.bsky.social! 🎉 Grateful for the spotlight on our research and its impact on understanding cancer immunology. www.nature.com/articles/d41... 👀👉 rdcu.be/d3cRz
Reposted by Anais Elewaut
🧪Cross-Dressing intratumoral monocytes fulfill the job of cDC1s in supporting tumor-infiltrating CD8 T cells in their anti-cancer functions. Great to have contributed some 🔬&🧫 to this tour de force study by @obenaufa.bsky.social
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
November 27, 2024 at 9:43 PM
🧪Cross-Dressing intratumoral monocytes fulfill the job of cDC1s in supporting tumor-infiltrating CD8 T cells in their anti-cancer functions. Great to have contributed some 🔬&🧫 to this tour de force study by @obenaufa.bsky.social
Reposted by Anais Elewaut
Cancer cells blunt monocyte IFN while increasing PGE2 to inhibit T cell immunity @obenaufa.bsky.social @aelewaut.bsky.social @guillemxtivill.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 28, 2024 at 12:26 PM
Cancer cells blunt monocyte IFN while increasing PGE2 to inhibit T cell immunity @obenaufa.bsky.social @aelewaut.bsky.social @guillemxtivill.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Extremely excited to see my PhD work in the @obenaufa.bsky.social published today in @natureportfolio.bsky.social 🤩. A big thank you to everyone who contributed, special thank you to my partner in crime @guillemxtivill.bsky.social - it was a lot of fun to work on this together! 🥳
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
November 27, 2024 at 7:53 PM
Extremely excited to see my PhD work in the @obenaufa.bsky.social published today in @natureportfolio.bsky.social 🤩. A big thank you to everyone who contributed, special thank you to my partner in crime @guillemxtivill.bsky.social - it was a lot of fun to work on this together! 🥳
Reposted by Anais Elewaut
#Immunotherapy has transformed #cancer treatment, but some cancers evade immune defenses, causing resistance.
@obenaufa.bsky.social's lab has discovered how inflammatory monocytes—a type of immune cell—can reactivate cancer-killing T cells within tumors.
Read more: imp.ac.at/news/article...
@obenaufa.bsky.social's lab has discovered how inflammatory monocytes—a type of immune cell—can reactivate cancer-killing T cells within tumors.
Read more: imp.ac.at/news/article...
November 27, 2024 at 4:17 PM
#Immunotherapy has transformed #cancer treatment, but some cancers evade immune defenses, causing resistance.
@obenaufa.bsky.social's lab has discovered how inflammatory monocytes—a type of immune cell—can reactivate cancer-killing T cells within tumors.
Read more: imp.ac.at/news/article...
@obenaufa.bsky.social's lab has discovered how inflammatory monocytes—a type of immune cell—can reactivate cancer-killing T cells within tumors.
Read more: imp.ac.at/news/article...
Reposted by Anais Elewaut
Super talk at #EMDS2024 by Anna Obenauf on myeloid cell hubs for T cell interactions in cancer 👏
And this is coming out in Nature 🧪 in just a few hours - congrats to Anais, Guillem, Anna & all authors 🥳🎉
@aelewaut.bsky.social
@guillemxtivill.bsky.social
@obenaufa.bsky.social
@impvienna.bsky.social
And this is coming out in Nature 🧪 in just a few hours - congrats to Anais, Guillem, Anna & all authors 🥳🎉
@aelewaut.bsky.social
@guillemxtivill.bsky.social
@obenaufa.bsky.social
@impvienna.bsky.social
November 27, 2024 at 2:07 PM
Super talk at #EMDS2024 by Anna Obenauf on myeloid cell hubs for T cell interactions in cancer 👏
And this is coming out in Nature 🧪 in just a few hours - congrats to Anais, Guillem, Anna & all authors 🥳🎉
@aelewaut.bsky.social
@guillemxtivill.bsky.social
@obenaufa.bsky.social
@impvienna.bsky.social
And this is coming out in Nature 🧪 in just a few hours - congrats to Anais, Guillem, Anna & all authors 🥳🎉
@aelewaut.bsky.social
@guillemxtivill.bsky.social
@obenaufa.bsky.social
@impvienna.bsky.social
Reposted by Anais Elewaut
Dendritic cells maintain the CAR T cell pool in irradiated tumors
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 25, 2024 at 4:43 PM
Dendritic cells maintain the CAR T cell pool in irradiated tumors
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...