David A. Sinclair, Ph.D.
@davidsinclairphd.bsky.social
Professor @Harvard researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own 🙏✌️
Pinned
All NIH grants supporting my lab's trainees and medical research have been terminated. I am not alone. We scientists work hard to make the world a better place & we will not go down without a fight 🥊
RIP James D. Watson, co-discoverer of DNAs double helix🥇Jim was a kind, generous mentor to me, who never hesitated to meet, give feedback, or share stories from the early days of molecular biology. His signed double helix hangs in my office as a reminder how one discovery can change the world 🙏
November 8, 2025 at 7:06 PM
RIP James D. Watson, co-discoverer of DNAs double helix🥇Jim was a kind, generous mentor to me, who never hesitated to meet, give feedback, or share stories from the early days of molecular biology. His signed double helix hangs in my office as a reminder how one discovery can change the world 🙏
Thrilled to have David Guyer join the @lifebiosciences.bsky.social board, maker of the first anti-VEGF eye drug, two successful biotech IPOs, the largest ever ex-US pharma deal, and sale of his latest company, EyeBio, for ~$3B to Merck in 2024. Midas touch 🙏✨🥇
www.lifebiosciences.com/life-bioscie...
www.lifebiosciences.com/life-bioscie...
Life Biosciences Appoints Industry Veteran David Guyer, M.D. to Board of Directors
Life Bio adds accomplished biotech leader to its Board as the company prepares for an early 2026 initiation of human trials BOSTON, November 3, 2025 – Life Biosciences (“Life Bio”), a biotechnology co...
www.lifebiosciences.com
November 4, 2025 at 5:27 AM
Thrilled to have David Guyer join the @lifebiosciences.bsky.social board, maker of the first anti-VEGF eye drug, two successful biotech IPOs, the largest ever ex-US pharma deal, and sale of his latest company, EyeBio, for ~$3B to Merck in 2024. Midas touch 🙏✨🥇
www.lifebiosciences.com/life-bioscie...
www.lifebiosciences.com/life-bioscie...
The AI-powered bioanalytics company NucleicAI.com, founded by Harvard geneticists Alireza Haghighi & David Sinclair, takes another big step forward towards their goal of building a global AI infrastructure to advance longevity science & affordable healthcare for all
tinyurl.com/fdn8ckd9
tinyurl.com/fdn8ckd9
Asia University Partners with NucleicAI to Build a Sovereign AI Life Science Data Platform
/PRNewswire/ -- Asia University will partner with NucleicAI LLC, a next-generation platform and data company specializing in AI-driven genomics, precision...
tinyurl.com
October 15, 2025 at 11:30 PM
The AI-powered bioanalytics company NucleicAI.com, founded by Harvard geneticists Alireza Haghighi & David Sinclair, takes another big step forward towards their goal of building a global AI infrastructure to advance longevity science & affordable healthcare for all
tinyurl.com/fdn8ckd9
tinyurl.com/fdn8ckd9
Centenarians don’t just live longer, they get sick later, and their diseases progress more slowly. Longevity isn’t just about living longer, it’s avoiding illnesses that kill you
September 13, 2025 at 3:02 PM
Centenarians don’t just live longer, they get sick later, and their diseases progress more slowly. Longevity isn’t just about living longer, it’s avoiding illnesses that kill you
We’re the first generation to understand aging at the molecular level. That knowledge changes everything
September 12, 2025 at 3:04 PM
We’re the first generation to understand aging at the molecular level. That knowledge changes everything
1 in 10,000 humans lives past 100. In some villages, it’s 1 in 10. Lifestyle matters
September 11, 2025 at 2:06 PM
1 in 10,000 humans lives past 100. In some villages, it’s 1 in 10. Lifestyle matters
Every healthy habit you choose is a vote for your future self
September 10, 2025 at 2:05 PM
Every healthy habit you choose is a vote for your future self
Computers in the future may weigh no more than 1.5 tons @popmech, 1949
September 9, 2025 at 2:08 PM
Computers in the future may weigh no more than 1.5 tons @popmech, 1949
Loneliness is as dangerous as smoking. Put your phone down and get out there
September 8, 2025 at 3:05 PM
Loneliness is as dangerous as smoking. Put your phone down and get out there
Aging is not inevitable, it’s biology. And biology can be changed
September 7, 2025 at 12:56 PM
Aging is not inevitable, it’s biology. And biology can be changed
NEWS: @lifebiosciences.bsky.social reports new drug candidate ER-300 improves liver health while ER-100 reverses age & restores healthy DNA methylation patterns in the monkey eye, with clear functional improvements in vision. Human trials set for January, 26. It’s happening...
🧵 tinyurl.com/4dysm7bv
🧵 tinyurl.com/4dysm7bv
Life Biosciences Presents New Data at ARDD 2025 on the Company’s Partial Epigenetic Reprogramming Platform in Liver and Ocular Diseases
ER-300 improves key biomarkers of liver health in an animal model of MASH These data, along with additional ER-100 preclinical data from a nonhuman primate model of NAION demonstrating clear restorati...
tinyurl.com
August 26, 2025 at 7:12 PM
NEWS: @lifebiosciences.bsky.social reports new drug candidate ER-300 improves liver health while ER-100 reverses age & restores healthy DNA methylation patterns in the monkey eye, with clear functional improvements in vision. Human trials set for January, 26. It’s happening...
🧵 tinyurl.com/4dysm7bv
🧵 tinyurl.com/4dysm7bv
Career award among casualties of ‘terrifying’ cuts affecting lab of David Sinclair news.harvard.edu/gazette/stor...
Young researcher’s ALS attack plan is now a no-go — Harvard Gazette
Career award among the casualties of "terrifying" cuts affecting lab of David Sinclair, which studies aging and disease.
news.harvard.edu
June 5, 2025 at 1:55 PM
Career award among casualties of ‘terrifying’ cuts affecting lab of David Sinclair news.harvard.edu/gazette/stor...
All NIH grants supporting my lab's trainees and medical research have been terminated. I am not alone. We scientists work hard to make the world a better place & we will not go down without a fight 🥊
May 16, 2025 at 1:17 AM
All NIH grants supporting my lab's trainees and medical research have been terminated. I am not alone. We scientists work hard to make the world a better place & we will not go down without a fight 🥊
Just posted our manuscript on "mPhenoAge," the first composite biological age measure for mice 🐭🧵 Proud of Alice and the entire team! 👏
@biorxivpreprint.bsky.social @volofoundation.bsky.social
tinyurl.com/544kzccz
@biorxivpreprint.bsky.social @volofoundation.bsky.social
tinyurl.com/544kzccz
May 6, 2025 at 5:50 PM
Just posted our manuscript on "mPhenoAge," the first composite biological age measure for mice 🐭🧵 Proud of Alice and the entire team! 👏
@biorxivpreprint.bsky.social @volofoundation.bsky.social
tinyurl.com/544kzccz
@biorxivpreprint.bsky.social @volofoundation.bsky.social
tinyurl.com/544kzccz
Polyphenols aren't just antioxidants. They signal to the body ➡️ defend and heal. New evidence indicates that polyphenols might prevent cancer by modulating small RNAs...a thread 🧵
March 24, 2025 at 9:06 PM
Polyphenols aren't just antioxidants. They signal to the body ➡️ defend and heal. New evidence indicates that polyphenols might prevent cancer by modulating small RNAs...a thread 🧵
If you turned 100 today and felt like you do now, would you want to die? Of course not.
So asking “How long do you want to live” is pointless
The right question is “When do you want to get frail and sick.”
So asking “How long do you want to live” is pointless
The right question is “When do you want to get frail and sick.”
February 5, 2025 at 12:53 AM
If you turned 100 today and felt like you do now, would you want to die? Of course not.
So asking “How long do you want to live” is pointless
The right question is “When do you want to get frail and sick.”
So asking “How long do you want to live” is pointless
The right question is “When do you want to get frail and sick.”
Reposted by David A. Sinclair, Ph.D.
Sabotage. Criminal sabotage.
"[The NSF] is planning to lay off between a quarter and a half of its staff in the next two months, a top National Science Foundation official said Tuesday."
www.eenews.net/articles/sci...
"[The NSF] is planning to lay off between a quarter and a half of its staff in the next two months, a top National Science Foundation official said Tuesday."
www.eenews.net/articles/sci...
Science funding agency threatened with mass layoffs
National Science Foundation staff heard the plans at a meeting Tuesday.
www.eenews.net
February 4, 2025 at 11:38 PM
Sabotage. Criminal sabotage.
"[The NSF] is planning to lay off between a quarter and a half of its staff in the next two months, a top National Science Foundation official said Tuesday."
www.eenews.net/articles/sci...
"[The NSF] is planning to lay off between a quarter and a half of its staff in the next two months, a top National Science Foundation official said Tuesday."
www.eenews.net/articles/sci...
Omega-3 plus vitamin D “slows biological aging by 3-4 months over 3 years, particularly when combined with exercise.” 👏
t.co/XGexiZFQg3
t.co/XGexiZFQg3
February 4, 2025 at 5:13 PM
Omega-3 plus vitamin D “slows biological aging by 3-4 months over 3 years, particularly when combined with exercise.” 👏
t.co/XGexiZFQg3
t.co/XGexiZFQg3
Reposted by David A. Sinclair, Ph.D.
The gears of the grantmaking machinery at NIH have begun moving again, after a 2-week standstill following a controversial ban on communications imposed by President Donald Trump. scim.ag/4aLQ0U6
NIH eases freeze on grant reviews imposed after Trump communications pause
Meetings of study sections and closed portion of councils back on track as agency also deals with diversity-related executive orders
scim.ag
February 4, 2025 at 2:04 AM
The gears of the grantmaking machinery at NIH have begun moving again, after a 2-week standstill following a controversial ban on communications imposed by President Donald Trump. scim.ag/4aLQ0U6
Our lab is 25 years old this week. A big thanks to past and present lab members who’ve work so hard to make the world a better place 🙏 🙏 🙏
Some photos and milestones 🧵
Some photos and milestones 🧵
February 3, 2025 at 11:04 PM
Our lab is 25 years old this week. A big thanks to past and present lab members who’ve work so hard to make the world a better place 🙏 🙏 🙏
Some photos and milestones 🧵
Some photos and milestones 🧵
The body's self-cleaning mechanism that recycles old proteins requires spermidine, a remarkable molecule that prevents hair loss in mice and extends the lifespan of every species tested
So what is spermidine and does it work in humans? 🧵
So what is spermidine and does it work in humans? 🧵
January 30, 2025 at 6:38 AM
The body's self-cleaning mechanism that recycles old proteins requires spermidine, a remarkable molecule that prevents hair loss in mice and extends the lifespan of every species tested
So what is spermidine and does it work in humans? 🧵
So what is spermidine and does it work in humans? 🧵
After 25 years at Harvard, my shelves are less a library and more an archaeological dig
January 28, 2025 at 11:59 PM
After 25 years at Harvard, my shelves are less a library and more an archaeological dig
My first post on BlueSky! Down from 470K followers on X to zero. Have some work to do
January 28, 2025 at 11:33 PM
My first post on BlueSky! Down from 470K followers on X to zero. Have some work to do